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Brain Tumor: early-phase trial registry
34 of 71 indexed Brain Tumor trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #197 of 28,707 conditions by registered trial count.
71 US clinical trials · 34 currently recruiting · #197 of 28,707 conditions by registered trial count
Brain Tumor: 71 US clinical trials tracked, 34 recruiting.
Brain Tumor is the subject of 71 registered US clinical trials on ClinicalTrials.gov, 34 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 28 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 6 of these trials.
Enrollment posture brief
Registry condition brain-tumor
OPEN 34 | RECR 48% | LATE 2 | EARLY 28 | RANK #197 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Aging (48% recruiting · 263 trials)
Brain Tumor lists 34 open slots (48% of 71 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Brain Tumor on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Brain Tumor is recruiting above its size-band peers.
34 of 71 indexed trials (47.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Brain Tumor trials is spread across many organizations.
Memorial Sloan Kettering Cancer Center accounts for 6 of 71 trials (8.5%). 43 distinct sponsors appear on at least one study for this condition label.
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Most Brain Tumor trials plan to enrol fewer than 100 people.
Median target enrolment is 43 among the 70 trials that report a genuine target (sentinel values excluded). 51 of those (72.9%) plan for fewer than 100 participants.
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Brain Tumor research is mostly interventional.
55 interventional and 16 observational studies make up this index (77.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
71 total, page 1 of 2
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
UMC Utrecht
NCT04075305
A Comprehensive Clinical fMRI Software Solution to Enable Mapping of Critical Functional Networks and Cerebrovascular Reactivity in the Brain
M.D. Anderson Cancer Center
NCT05342454
European Prospective Investigation Into Childhood Cancer
Columbia University
NCT05375617
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
GT Medical Technologies
NCT04427384
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders
Southwest Autism Research & Resource Center
NCT04322734
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
Apollomics
NCT03175224
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
Ivy Brain Tumor Center
NCT06388733
Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT05658731
Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
Tango Therapeutics
NCT06810544
HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)
Dartmouth-Hitchcock Medical Center
NCT06930846
Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases
Brigham and Women's Hospital
NCT04033497
Ommaya Reservoir Placement for Brain Tumor Biomarker Access
Mayo Clinic
NCT04692337
Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy
Massachusetts General Hospital
NCT03286335
A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations
National Cancer Institute (NCI)
NCT05588141
Mapping of Human Cognition
The University of Texas Health Science Center, Houston
NCT05989893
Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM
Northwell Health
NCT03213002
Development of MRF for Characterization of Brain Tumors After Radiotherapy
Case Comprehensive Cancer Center
NCT06101069
A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas
Case Comprehensive Cancer Center
NCT07003542
Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors
St. Jude Children's Research Hospital
NCT05947045
Systematic Light Exposure in Pediatric Brain Tumor Survivors
Baylor College of Medicine
NCT05340881
Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA
Northwell Health
NCT02800486
Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma
Northwell Health
NCT02861898
LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)
University of Maryland, Baltimore
NCT04699773
LITT Followed by Hypofractionated RT for Recurrent Gliomas
University of Maryland, Baltimore
NCT04181684
Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
InSightec
NCT05317858
Visual Plasticity Following Brain Lesions
Georgetown University
NCT07105358
Non-invasive Glioma Characterization Through Molecular Imaging
University of Miami
NCT03684109
A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma
Ugonma Chukwueke
NCT06552260
Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.
Henry Ford Health System
NCT05686798
A Study of Sotorasib in People With Brain Tumors
Memorial Sloan Kettering Cancer Center
NCT06807619
Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures
Stanford University
NCT04085887
Brodalumab in the Treatment of Immune-Related Adverse Events
Brian Henick, MD
NCT06673329
Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)
InSightec
NCT05630209
Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption
Mayo Clinic
NCT05733312
A Longitudinal Assessment of Frailty in Young Adult Survivors of Childhood Cancer
St. Jude Children's Research Hospital
NCT02256137
Multi-Parametric Quantitative MR Imaging in Evaluation of Brain Tumors
Case Comprehensive Cancer Center
NCT02956291
Perioperative Evaluation of Cerebellar Tumors
Duke University
NCT04463979
Abemaciclib (LY2835219) in Patients With Recurrent Primary Brain Tumors
Memorial Sloan Kettering Cancer Center
NCT03220646
A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2
Dana-Farber Cancer Institute
NCT03152318
A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors
Medical College of Wisconsin
NCT05023434
Observational Trial of the Impact of Radiation Dose in Children With Brain and Skull Base Tumors.
Baptist Health South Florida
NCT03972514
Understanding the Late Effects of Surviving a Pediatric Brain Tumor
Memorial Sloan Kettering Cancer Center
NCT03208387
Multi-antigen T Cell Infusion Against Neuro-oncologic Disease
Catherine Bollard
NCT03652545
Evaluation of Preoperative Functional Magnetic Resonance Imaging (fMRI) in Patients With Brain Tumors
Memorial Sloan Kettering Cancer Center
NCT03604302
Tolerability and Activity of Brivaracetam (BRV) in Patients With Diffuse Gliomas
University of Rochester
NCT05029960
A Study of How Proton Beam Radiotherapy (PBRT) Affects Brain Function and Quality of Life in Children and Young Adults Undergoing Treatment for a Brain Tumor
Memorial Sloan Kettering Cancer Center
NCT05288439
Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study
St. Jude Children's Research Hospital
NCT05128903
A Trial of Increased Dose Intensity Modulated Proton Therapy (IMPT) for High-Grade Meningiomas
Massachusetts General Hospital
NCT02693990
Comprehensive Evaluation of Tumor Oxygenation, Metabolism and Blood Supply of High Grade Glioma and Cervical Cancers Using Dynamic FAZA PET and Multiparametric MR
M.D. Anderson Cancer Center
NCT05047913
Proton Craniospinal Irradiation With Bone Sparing to Decrease Growth Decrement From Radiation
Massachusetts General Hospital
NCT03281889
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 9 |
| Phase 3 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Brain Tumor records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Brain Tumor trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Brain Tumor page
71 registered trials, 34 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 34 Brain Tumor trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Memorial Sloan Kettering Cancer Center sponsors the most Brain Tumor trials on record, review their full trial history before evaluating a specific study. See Memorial Sloan Kettering Cancer Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Brain Tumor condition card totals 71 registered trials; most-linked intervention Temozolomide; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.