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Brain Tumor clinical trials
Every US clinical trial registered for Brain Tumor — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
71 US clinical trials · 34 currently recruiting
The research picture
Brain Tumor has 71 registered US clinical trials, 34 of them open to new participants right now — about 48% of the total.
- 34
- recruiting participants now
- 48%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 6
- top sponsor: Memorial Sloan Kettering Cancer Center
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
UMC Utrecht
NCT04075305
A Comprehensive Clinical fMRI Software Solution to Enable Mapping of Critical Functional Networks and Cerebrovascular Reactivity in the Brain
M.D. Anderson Cancer Center
NCT05342454
European Prospective Investigation Into Childhood Cancer
Columbia University
NCT05375617
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
GT Medical Technologies
NCT04427384
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders
Southwest Autism Research & Resource Center
NCT04322734
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
Apollomics
NCT03175224
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
Ivy Brain Tumor Center
NCT06388733
Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT05658731
Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
Tango Therapeutics
NCT06810544
HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)
Dartmouth-Hitchcock Medical Center
NCT06930846
Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases
Brigham and Women's Hospital
NCT04033497
Ommaya Reservoir Placement for Brain Tumor Biomarker Access
Mayo Clinic
NCT04692337
Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy
Massachusetts General Hospital
NCT03286335
A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations
National Cancer Institute (NCI)
NCT05588141
Mapping of Human Cognition
The University of Texas Health Science Center, Houston
NCT05989893
Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM
Northwell Health
NCT03213002
Development of MRF for Characterization of Brain Tumors After Radiotherapy
Case Comprehensive Cancer Center
NCT06101069
A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas
Case Comprehensive Cancer Center
NCT07003542
Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors
St. Jude Children's Research Hospital
NCT05947045
Systematic Light Exposure in Pediatric Brain Tumor Survivors
Baylor College of Medicine
NCT05340881
Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA
Northwell Health
NCT02800486
Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma
Northwell Health
NCT02861898
LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)
University of Maryland, Baltimore
NCT04699773
LITT Followed by Hypofractionated RT for Recurrent Gliomas
University of Maryland, Baltimore
NCT04181684
Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
InSightec
NCT05317858
Visual Plasticity Following Brain Lesions
Georgetown University
NCT07105358
Non-invasive Glioma Characterization Through Molecular Imaging
University of Miami
NCT03684109
A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma
Ugonma Chukwueke
NCT06552260
Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.
Henry Ford Health System
NCT05686798
A Study of Sotorasib in People With Brain Tumors
Memorial Sloan Kettering Cancer Center
NCT06807619
Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures
Stanford University
NCT04085887
Brodalumab in the Treatment of Immune-Related Adverse Events
Brian Henick, MD
NCT06673329
Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)
InSightec
NCT05630209
Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption
Mayo Clinic
NCT05733312
A Longitudinal Assessment of Frailty in Young Adult Survivors of Childhood Cancer
St. Jude Children's Research Hospital
NCT02256137
Multi-Parametric Quantitative MR Imaging in Evaluation of Brain Tumors
Case Comprehensive Cancer Center
NCT02956291
Perioperative Evaluation of Cerebellar Tumors
Duke University
NCT04463979
Abemaciclib (LY2835219) in Patients With Recurrent Primary Brain Tumors
Memorial Sloan Kettering Cancer Center
NCT03220646
A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2
Dana-Farber Cancer Institute
NCT03152318
A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors
Medical College of Wisconsin
NCT05023434
Observational Trial of the Impact of Radiation Dose in Children With Brain and Skull Base Tumors.
Baptist Health South Florida
NCT03972514
Understanding the Late Effects of Surviving a Pediatric Brain Tumor
Memorial Sloan Kettering Cancer Center
NCT03208387
Multi-antigen T Cell Infusion Against Neuro-oncologic Disease
Catherine Bollard
NCT03652545
Evaluation of Preoperative Functional Magnetic Resonance Imaging (fMRI) in Patients With Brain Tumors
Memorial Sloan Kettering Cancer Center
NCT03604302
Tolerability and Activity of Brivaracetam (BRV) in Patients With Diffuse Gliomas
University of Rochester
NCT05029960
A Study of How Proton Beam Radiotherapy (PBRT) Affects Brain Function and Quality of Life in Children and Young Adults Undergoing Treatment for a Brain Tumor
Memorial Sloan Kettering Cancer Center
NCT05288439
Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study
St. Jude Children's Research Hospital
NCT05128903
A Trial of Increased Dose Intensity Modulated Proton Therapy (IMPT) for High-Grade Meningiomas
Massachusetts General Hospital
NCT02693990
Comprehensive Evaluation of Tumor Oxygenation, Metabolism and Blood Supply of High Grade Glioma and Cervical Cancers Using Dynamic FAZA PET and Multiparametric MR
M.D. Anderson Cancer Center
NCT05047913
Proton Craniospinal Irradiation With Bone Sparing to Decrease Growth Decrement From Radiation
Massachusetts General Hospital
NCT03281889
MRI-Guided Focused Ultrasound Feasibility Study for Brain Tumors
InSightec
NCT00147056
Natural History of and Specimen Banking for People With Tumors of the Central Nervous System
National Cancer Institute (NCI)
NCT02851706
Illness Management and Parental Adjustment to Cancer Treatment
Children's Hospital Medical Center, Cincinnati
NCT02505165
Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas
Duke University
NCT00597402
Brain Tumor Patient-Caregiver Congruence, MD Anderson Symptom Inventory-Brain Tumor Module (MDASI-BT)
M.D. Anderson Cancer Center
NCT00748774
Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma
Massachusetts General Hospital
NCT01063114
Safety and Feasibility of the Infinity Catheter for Radial Access
Rutgers, The State University of New Jersey
NCT04553549
In-Room PET in Proton Radiation Therapy
Massachusetts General Hospital
NCT01228448
A Novel Health Information Technology System (BMT Roadmap) for Pediatric BMT Patients and Caregivers
University of Michigan Rogel Cancer Center
NCT02409121
The Good Patient Study
St. Jude Children's Research Hospital
NCT02199548
C-SMART: Cognitive Strategies, Mindfulness, and Rehabilitation Therapy for Patients With Primary Brain Tumors
Virginia Commonwealth University
NCT05984667
Immune Reconstitution in Oncology Patients Following Autologous Stem Cell Transplant
St. Jude Children's Research Hospital
NCT01540175
LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma
Istari Oncology
NCT04479241
PPX, Temozolomide, and Concurrent Radiation for Newly Diagnosed Brain Tumors
howard safran
NCT00763750
IDH1 Peptide Vaccine for Recurrent Grade II Glioma
Katy Peters, MD, PhD
NCT02193347
Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors
University of Florida
NCT01111097
Monteris AutoLITT™ FIM Safety Trial for Recurrent/Progressive Brain Tumors
Monteris Medical
NCT00747253
GW572016 to Treat Recurrent Malignant Brain Tumors
National Cancer Institute (NCI)
NCT00107003
Neurosurgical Use of Interstitial Laser Therapy (ILT)
Brigham and Women's Hospital
NCT00207350
PET and MRI Imaging of Brain Tumors Using [18F]PARPi
Memorial Sloan Kettering Cancer Center
NCT04173104
Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors
National Cancer Institute (NCI)
NCT00019630
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 9 |
| Phase 3 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Brain Tumor Trial Landscape
ClinicalTrials.gov lists 71 US studies indexed under Brain Tumor, and 34 of those are currently open to recruitment — roughly 48% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Brain Tumor shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 28 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Brain Tumor is led by Memorial Sloan Kettering Cancer Center with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 71 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Brain Tumor?
PlainTrial tracks 71 US clinical trials for Brain Tumor, of which 34 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Brain Tumor?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.