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ClinicalTrials.gov 34 recruiting now official registry

Brain Tumor clinical trials

Every US clinical trial registered for Brain Tumor — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

71 US clinical trials · 34 currently recruiting

The research picture

Brain Tumor has 71 registered US clinical trials, 34 of them open to new participants right now — about 48% of the total.

34
recruiting participants now
48%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
6
top sponsor: Memorial Sloan Kettering Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 8,000 participants

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

UMC Utrecht

NCT04075305

RECRUITING 1,720 participants

A Comprehensive Clinical fMRI Software Solution to Enable Mapping of Critical Functional Networks and Cerebrovascular Reactivity in the Brain

M.D. Anderson Cancer Center

NCT05342454

RECRUITING 1,400 participants

European Prospective Investigation Into Childhood Cancer

Columbia University

NCT05375617

RECRUITING 600 participants

Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)

GT Medical Technologies

NCT04427384

RECRUITING 500 participants

Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders

Southwest Autism Research & Resource Center

NCT04322734

RECRUITING Phase 2 497 participants

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

Apollomics

NCT03175224

RECRUITING Phase 3 450 participants

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Ivy Brain Tumor Center

NCT06388733

RECRUITING NA 338 participants

Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05658731

RECRUITING Phase 1 191 participants

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

Tango Therapeutics

NCT06810544

RECRUITING NA 125 participants

HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)

Dartmouth-Hitchcock Medical Center

NCT06930846

RECRUITING NA 101 participants

Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases

Brigham and Women's Hospital

NCT04033497

RECRUITING NA 100 participants

Ommaya Reservoir Placement for Brain Tumor Biomarker Access

Mayo Clinic

NCT04692337

RECRUITING NA 100 participants

Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

Massachusetts General Hospital

NCT03286335

RECRUITING Phase 1 96 participants

A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

National Cancer Institute (NCI)

NCT05588141

RECRUITING NA 75 participants

Mapping of Human Cognition

The University of Texas Health Science Center, Houston

NCT05989893

RECRUITING Phase 1 67 participants

Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM

Northwell Health

NCT03213002

RECRUITING NA 60 participants

Development of MRF for Characterization of Brain Tumors After Radiotherapy

Case Comprehensive Cancer Center

NCT06101069

RECRUITING Phase 2 48 participants

A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas

Case Comprehensive Cancer Center

NCT07003542

RECRUITING NA 45 participants

Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors

St. Jude Children's Research Hospital

NCT05947045

RECRUITING NA 40 participants

Systematic Light Exposure in Pediatric Brain Tumor Survivors

Baylor College of Medicine

NCT05340881

RECRUITING Phase 2 37 participants

Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

Northwell Health

NCT02800486

RECRUITING Phase 1 33 participants

Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma

Northwell Health

NCT02861898

RECRUITING NA 32 participants

LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

University of Maryland, Baltimore

NCT04699773

RECRUITING NA 32 participants

LITT Followed by Hypofractionated RT for Recurrent Gliomas

University of Maryland, Baltimore

NCT04181684

RECRUITING Phase 3 30 participants

Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

InSightec

NCT05317858

RECRUITING NA 30 participants

Visual Plasticity Following Brain Lesions

Georgetown University

NCT07105358

RECRUITING NA 30 participants

Non-invasive Glioma Characterization Through Molecular Imaging

University of Miami

NCT03684109

RECRUITING Early Phase 1 27 participants

A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

Ugonma Chukwueke

NCT06552260

RECRUITING Phase 1 18 participants

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Henry Ford Health System

NCT05686798

RECRUITING Phase 1 16 participants

A Study of Sotorasib in People With Brain Tumors

Memorial Sloan Kettering Cancer Center

NCT06807619

RECRUITING Phase 1 12 participants

Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures

Stanford University

NCT04085887

RECRUITING Phase 1 11 participants

Brodalumab in the Treatment of Immune-Related Adverse Events

Brian Henick, MD

NCT06673329

RECRUITING Phase 1 10 participants

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)

InSightec

NCT05630209

RECRUITING NA 6 participants

Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption

Mayo Clinic

NCT05733312

ACTIVE NOT RECRUITING 1,564 participants

A Longitudinal Assessment of Frailty in Young Adult Survivors of Childhood Cancer

St. Jude Children's Research Hospital

NCT02256137

ACTIVE NOT RECRUITING NA 172 participants

Multi-Parametric Quantitative MR Imaging in Evaluation of Brain Tumors

Case Comprehensive Cancer Center

NCT02956291

ACTIVE NOT RECRUITING 66 participants

Perioperative Evaluation of Cerebellar Tumors

Duke University

NCT04463979

ACTIVE NOT RECRUITING Phase 2 64 participants

Abemaciclib (LY2835219) in Patients With Recurrent Primary Brain Tumors

Memorial Sloan Kettering Cancer Center

NCT03220646

ACTIVE NOT RECRUITING Phase 1 62 participants

A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2

Dana-Farber Cancer Institute

NCT03152318

ACTIVE NOT RECRUITING 60 participants

A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors

Medical College of Wisconsin

NCT05023434

ACTIVE NOT RECRUITING 60 participants

Observational Trial of the Impact of Radiation Dose in Children With Brain and Skull Base Tumors.

Baptist Health South Florida

NCT03972514

ACTIVE NOT RECRUITING 42 participants

Understanding the Late Effects of Surviving a Pediatric Brain Tumor

Memorial Sloan Kettering Cancer Center

NCT03208387

ACTIVE NOT RECRUITING Phase 1 33 participants

Multi-antigen T Cell Infusion Against Neuro-oncologic Disease

Catherine Bollard

NCT03652545

ACTIVE NOT RECRUITING NA 33 participants

Evaluation of Preoperative Functional Magnetic Resonance Imaging (fMRI) in Patients With Brain Tumors

Memorial Sloan Kettering Cancer Center

NCT03604302

ACTIVE NOT RECRUITING Early Phase 1 30 participants

Tolerability and Activity of Brivaracetam (BRV) in Patients With Diffuse Gliomas

University of Rochester

NCT05029960

ACTIVE NOT RECRUITING NA 30 participants

A Study of How Proton Beam Radiotherapy (PBRT) Affects Brain Function and Quality of Life in Children and Young Adults Undergoing Treatment for a Brain Tumor

Memorial Sloan Kettering Cancer Center

NCT05288439

ACTIVE NOT RECRUITING Phase 2 22 participants

Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study

St. Jude Children's Research Hospital

NCT05128903

ACTIVE NOT RECRUITING NA 21 participants

A Trial of Increased Dose Intensity Modulated Proton Therapy (IMPT) for High-Grade Meningiomas

Massachusetts General Hospital

NCT02693990

ACTIVE NOT RECRUITING Early Phase 1 20 participants

Comprehensive Evaluation of Tumor Oxygenation, Metabolism and Blood Supply of High Grade Glioma and Cervical Cancers Using Dynamic FAZA PET and Multiparametric MR

M.D. Anderson Cancer Center

NCT05047913

ACTIVE NOT RECRUITING NA 20 participants

Proton Craniospinal Irradiation With Bone Sparing to Decrease Growth Decrement From Radiation

Massachusetts General Hospital

NCT03281889

ACTIVE NOT RECRUITING NA 10 participants

MRI-Guided Focused Ultrasound Feasibility Study for Brain Tumors

InSightec

NCT00147056

COMPLETED 1,214 participants

Natural History of and Specimen Banking for People With Tumors of the Central Nervous System

National Cancer Institute (NCI)

NCT02851706

COMPLETED NA 279 participants

Illness Management and Parental Adjustment to Cancer Treatment

Children's Hospital Medical Center, Cincinnati

NCT02505165

COMPLETED Phase 2 125 participants

Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas

Duke University

NCT00597402

COMPLETED 115 participants

Brain Tumor Patient-Caregiver Congruence, MD Anderson Symptom Inventory-Brain Tumor Module (MDASI-BT)

M.D. Anderson Cancer Center

NCT00748774

COMPLETED NA 90 participants

Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma

Massachusetts General Hospital

NCT01063114

COMPLETED 80 participants

Safety and Feasibility of the Infinity Catheter for Radial Access

Rutgers, The State University of New Jersey

NCT04553549

COMPLETED NA 59 participants

In-Room PET in Proton Radiation Therapy

Massachusetts General Hospital

NCT01228448

COMPLETED NA 59 participants

A Novel Health Information Technology System (BMT Roadmap) for Pediatric BMT Patients and Caregivers

University of Michigan Rogel Cancer Center

NCT02409121

COMPLETED 43 participants

The Good Patient Study

St. Jude Children's Research Hospital

NCT02199548

COMPLETED 32 participants

C-SMART: Cognitive Strategies, Mindfulness, and Rehabilitation Therapy for Patients With Primary Brain Tumors

Virginia Commonwealth University

NCT05984667

COMPLETED 31 participants

Immune Reconstitution in Oncology Patients Following Autologous Stem Cell Transplant

St. Jude Children's Research Hospital

NCT01540175

COMPLETED Phase 2 25 participants

LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma

Istari Oncology

NCT04479241

COMPLETED Phase 2 25 participants

PPX, Temozolomide, and Concurrent Radiation for Newly Diagnosed Brain Tumors

howard safran

NCT00763750

COMPLETED Phase 1 24 participants

IDH1 Peptide Vaccine for Recurrent Grade II Glioma

Katy Peters, MD, PhD

NCT02193347

COMPLETED Phase 1 15 participants

Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors

University of Florida

NCT01111097

COMPLETED Phase 1 10 participants

Monteris AutoLITT™ FIM Safety Trial for Recurrent/Progressive Brain Tumors

Monteris Medical

NCT00747253

COMPLETED Phase 2 9 participants

GW572016 to Treat Recurrent Malignant Brain Tumors

National Cancer Institute (NCI)

NCT00107003

COMPLETED NA 6 participants

Neurosurgical Use of Interstitial Laser Therapy (ILT)

Brigham and Women's Hospital

NCT00207350

COMPLETED Early Phase 1 5 participants

PET and MRI Imaging of Brain Tumors Using [18F]PARPi

Memorial Sloan Kettering Cancer Center

NCT04173104

COMPLETED Phase 1

Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors

National Cancer Institute (NCI)

NCT00019630

Phase Distribution

PhaseTrial count
Phase 1 19
Phase 2 9
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Brain Tumor Trial Landscape

ClinicalTrials.gov lists 71 US studies indexed under Brain Tumor, and 34 of those are currently open to recruitment — roughly 48% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Brain Tumor shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 28 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Brain Tumor is led by Memorial Sloan Kettering Cancer Center with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 71 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Brain Tumor?

PlainTrial tracks 71 US clinical trials for Brain Tumor, of which 34 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Brain Tumor?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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