National Heart, Lung, and Blood Institute (NHLBI)
Trial Pipeline
Platelet Volunteers, Longitudinal and Multi-omic Study
NCT07137429
Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib
NCT07428707
Baricitinib in the Treatment of Kohlmeier-Degos Disease in Patients With Neurological Involvement
NCT06923072
NHLBI and Cook Trans-Atrial Intra-Pericardial Tricuspid Annuloplasty (TRAIPTA) Early Feasibility Study
NCT06479824
Natural History of Uncommon Dyslipidemias, Rare Lipid Disorders and Unusual Atherosclerotic Conditions
NCT06676046
Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease
NCT05904093
OurSleepKit To Support CPAP Adherence
NCT06621511
Thrombosis and Inflammation in Vessels Initiative (TIVI)
NCT06552767
Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis
NCT06615986
Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling
NCT06313398
Technical Development of Cardiovascular Magnetic Resonance Imaging
NCT04927429
Early Detection of Infectious and Noninfectious Lung Diseases Following Allogeneic Hematopoietic Stem Cell Transplantation
NCT06093867
Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus
NCT06032923
JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure
NCT05998408
Healing Within: Mindfulness Smoking Cessation Intervention
NCT07013968
Study of Intravenous ZMA001 in Healthy Subjects
NCT05967299
Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax
NCT05724121
Vaccine Responses in Patients With B Cell Malignancies
NCT05170399
Controls and Healthy Vasculature Initiative
NCT05403151
Natural History Study of CADASIL
NCT05072483
Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies
NCT05213572
Natural History of Acquired and Inherited Bone Marrow Failure Syndromes
NCT05012111
Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women
NCT04014348
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers
NCT04216342
Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)
NCT04304820
CHIP/CCUS Natural History Protocol
NCT04102423
Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels
NCT04008368
Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
NCT03986034
Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH Using Peripheral Blood Stem Cells and Post-transplant Cyclophosphamide for GVHD Prophylaxis
NCT03520647
Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease
NCT03685721
Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults
NCT03372733
Vascular Disease Discovery Protocol
NCT03538639
Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
NCT03581318
Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments
NCT03288207
Low-Dose Danazol for the Treatment of Telomere Related Diseases
NCT03312400
Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System
NCT03331380
Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome
NCT03173937
Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank
NCT02706639
Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)
NCT02543996
Genome Transplant Dynamics
NCT02423070
Prospective Evaluation of Next Generation CT Reconstruction (NextGenIR)
NCT02417714
Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention
NCT01927783
Nebulized or Inhaled Albuterol for Lymphangioleiomyomatosis
NCT01799538
Evaluating New Radiation Techniques for Cardiovascular Imaging
NCT01621594
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells
NCT01174108
Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System
NCT01143454
Natural History of Bronchiectasis
NCT00943514
Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)
NCT00923507
Collection of Lung Fluid and Tissue Samples for Research
NCT00471250
Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers
NCT00442195
Long-term Evaluation and Follow-up Care of Patients Treated With Stem Cell Transplants
NCT00106925
Natural History of Sickle Cell Disease
NCT00081523
Genetic Basis of Immunodeficiency
NCT00055172
Causes and Natural History of Dyslipidemias
NCT00353782
Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members
NCT00071045
Study of Skin Tumors in Tuberous Sclerosis
NCT00001975
Role of Genetic Factors in the Development of Lung Disease
NCT00001532
Improved Methods of Cell Selection for Bone Marrow Transplant Alternatives
NCT00001529
Study of the Disease Process of Lymphangioleiomyomatosis
NCT00001465
Epcoritamab in Chronic Lymphocytic Leukemia and Richter Syndrome
NCT06676033
Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease
NCT05675436
Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ Function
NCT06145282
Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia
NCT05357482
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat
NCT04610866
NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study
NCT03929913
Eltrombopag for People With Fanconi Anemia
NCT03206086
HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma
NCT03354390
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease
NCT03077542
Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia Responsive to Immunosuppressive Therapy
NCT02979873
A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Treatment-Naive CLL
NCT02514083
Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure
NCT02105766
Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia
NCT01623167
PCI-32765 for Special Cases of Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT01500733
Eltrombopag for Moderate Aplastic Anemia
NCT01328587
Haploidentical PBMC Transplant for Severe Congenital Anemias
NCT00977691
Hispanic Community Health Study / Study of Latinos
NCT02060344
The Jackson Heart Study of Cardiovascular Disease Among African Americans
NCT00005485
Cardiovascular Health Study (CHS)
NCT00005133
JAK/STAT Inhibition in CNS Kohlmeier-Degos Disease
NCT05998395
Treatment of Refractory Diamond-Blackfan Anemia With Eltrombopag
NCT04269889
Patients' Long-Term Survival of Obstructive Hypertrophic Cardiomyopathy (HCM)
NCT04603521
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis
NCT04271735
Extracellular RNAs in Relation to Cardiometabolic Risk
NCT03225196
Effect of Fish Oil Enriched In Omega-11 Fatty Acid On Lipoprotein Metabolism In Adults
NCT03043365
Pathophysiology of Acute Pain in Patients With Sickle Cell Disease
NCT03049475
Effect of Fasting and Refeeding on T-cell Fate
NCT02719899
Comparison of EPA and DHA-Rich Fish Oils on Lipoprotein Metabolism In Adults
NCT02514070
Allogeneic Hematopoietic Stem Cell Transplantation With Ixazomib for High Risk Multiple Myeloma (BMT CTN 1302)
NCT02440464
dbGaP Protocol: Genetic Variants Associated With Pentalogy of Cantrell
NCT02430376
Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary Fibrosis
NCT02315586
Prospective International Study of Coronary Subtraction Using 320 Detector Row CT (CorSub)
NCT02303067
Complement Inhibition Using Eculizumab to Overcome Platelet Transfusion Refractoriness in Patients With Severe Thrombocytopenia
NCT02298933
Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0
NCT02290392
Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access
NCT02280824
Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)
NCT02208037
Preventing Stem Cell Transplant Complications With a Blood Separator Machine
NCT01866839
Pilot Study of Strength Testing in Overweight Women With or Without Insulin Resistance
NCT01862757
Medical Arm of the Interagency Registry for Mechanically Assisted Circulatory Support
NCT01932294
Longitudinal Observational Study of Severe Asthma
NCT01780142
Etidronate for Arterial Calcifications Due to Deficiency in CD73 (ACDC)
NCT01585402
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 31 |
| Phase 2 | 95 |
| Phase 3 | 7 |
| Phase 4 | 2 |
Therapeutic Areas
What the Pipeline for National Heart, Lung, and Blood Institute (NHLBI) Shows
According to the ClinicalTrials.gov registry, National Heart, Lung, and Blood Institute (NHLBI) is linked to 381 US clinical trials across every stage of research activity. Of those, 259 studies are currently recruiting — about 68% of the sponsor's indexed portfolio — and 103 are already marked complete, representing roughly 27% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
The phase mix for National Heart, Lung, and Blood Institute (NHLBI) reports 9 late-stage studies (Phase 3 and Phase 4 combined) and 126 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
The top therapeutic focus area indexed for National Heart, Lung, and Blood Institute (NHLBI) is Atherosclerosis with 12 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology — how this data is sourced, computed, and verified.