National Heart, Lung, and Blood Institute (NHLBI)

381 total trials 259 currently recruiting 103 completed

Trial Pipeline

RECRUITING

Platelet Volunteers, Longitudinal and Multi-omic Study

NCT07137429

RECRUITING Early Phase 1

Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib

NCT07428707

RECRUITING Phase 2

Baricitinib in the Treatment of Kohlmeier-Degos Disease in Patients With Neurological Involvement

NCT06923072

RECRUITING NA

NHLBI and Cook Trans-Atrial Intra-Pericardial Tricuspid Annuloplasty (TRAIPTA) Early Feasibility Study

NCT06479824

RECRUITING

Natural History of Uncommon Dyslipidemias, Rare Lipid Disorders and Unusual Atherosclerotic Conditions

NCT06676046

RECRUITING Phase 1

Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease

NCT05904093

RECRUITING NA

OurSleepKit To Support CPAP Adherence

NCT06621511

RECRUITING

Thrombosis and Inflammation in Vessels Initiative (TIVI)

NCT06552767

RECRUITING Early Phase 1

Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis

NCT06615986

RECRUITING Early Phase 1

Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling

NCT06313398

RECRUITING

Technical Development of Cardiovascular Magnetic Resonance Imaging

NCT04927429

RECRUITING

Early Detection of Infectious and Noninfectious Lung Diseases Following Allogeneic Hematopoietic Stem Cell Transplantation

NCT06093867

RECRUITING Phase 1

Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus

NCT06032923

RECRUITING Phase 1

JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure

NCT05998408

RECRUITING NA

Healing Within: Mindfulness Smoking Cessation Intervention

NCT07013968

RECRUITING Phase 1

Study of Intravenous ZMA001 in Healthy Subjects

NCT05967299

RECRUITING

Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax

NCT05724121

RECRUITING Phase 4

Vaccine Responses in Patients With B Cell Malignancies

NCT05170399

RECRUITING

Controls and Healthy Vasculature Initiative

NCT05403151

RECRUITING

Natural History Study of CADASIL

NCT05072483

RECRUITING

Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

NCT05213572

RECRUITING

Natural History of Acquired and Inherited Bone Marrow Failure Syndromes

NCT05012111

RECRUITING

Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women

NCT04014348

RECRUITING Phase 1

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers

NCT04216342

RECRUITING Phase 2

Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

NCT04304820

RECRUITING

CHIP/CCUS Natural History Protocol

NCT04102423

RECRUITING Phase 1

Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels

NCT04008368

RECRUITING Phase 2

Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)

NCT03986034

RECRUITING Phase 2

Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH Using Peripheral Blood Stem Cells and Post-transplant Cyclophosphamide for GVHD Prophylaxis

NCT03520647

RECRUITING

Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease

NCT03685721

RECRUITING Phase 2

Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults

NCT03372733

RECRUITING

Vascular Disease Discovery Protocol

NCT03538639

RECRUITING

Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging

NCT03581318

RECRUITING NA

Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments

NCT03288207

RECRUITING Phase 2

Low-Dose Danazol for the Treatment of Telomere Related Diseases

NCT03312400

RECRUITING NA

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

NCT03331380

RECRUITING Phase 1

Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome

NCT03173937

RECRUITING

Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank

NCT02706639

RECRUITING

Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)

NCT02543996

RECRUITING

Genome Transplant Dynamics

NCT02423070

RECRUITING

Prospective Evaluation of Next Generation CT Reconstruction (NextGenIR)

NCT02417714

RECRUITING

Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention

NCT01927783

RECRUITING Phase 1

Nebulized or Inhaled Albuterol for Lymphangioleiomyomatosis

NCT01799538

RECRUITING NA

Evaluating New Radiation Techniques for Cardiovascular Imaging

NCT01621594

RECRUITING Phase 2

Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

NCT01174108

RECRUITING

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

NCT01143454

RECRUITING

Natural History of Bronchiectasis

NCT00943514

RECRUITING

Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)

NCT00923507

RECRUITING

Collection of Lung Fluid and Tissue Samples for Research

NCT00471250

RECRUITING

Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers

NCT00442195

RECRUITING

Long-term Evaluation and Follow-up Care of Patients Treated With Stem Cell Transplants

NCT00106925

RECRUITING

Natural History of Sickle Cell Disease

NCT00081523

RECRUITING

Genetic Basis of Immunodeficiency

NCT00055172

RECRUITING

Causes and Natural History of Dyslipidemias

NCT00353782

RECRUITING

Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members

NCT00071045

RECRUITING

Study of Skin Tumors in Tuberous Sclerosis

NCT00001975

RECRUITING

Role of Genetic Factors in the Development of Lung Disease

NCT00001532

RECRUITING

Improved Methods of Cell Selection for Bone Marrow Transplant Alternatives

NCT00001529

RECRUITING

Study of the Disease Process of Lymphangioleiomyomatosis

NCT00001465

ACTIVE NOT RECRUITING Phase 1

Epcoritamab in Chronic Lymphocytic Leukemia and Richter Syndrome

NCT06676033

ACTIVE NOT RECRUITING

Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease

NCT05675436

ACTIVE NOT RECRUITING Phase 1

Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ Function

NCT06145282

ACTIVE NOT RECRUITING Phase 1

Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia

NCT05357482

ACTIVE NOT RECRUITING Phase 1

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat

NCT04610866

ACTIVE NOT RECRUITING NA

NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study

NCT03929913

ACTIVE NOT RECRUITING Phase 2

Eltrombopag for People With Fanconi Anemia

NCT03206086

ACTIVE NOT RECRUITING Phase 1

HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

NCT03354390

ACTIVE NOT RECRUITING Phase 1

Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

NCT03077542

ACTIVE NOT RECRUITING Phase 2

Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

NCT02979873

ACTIVE NOT RECRUITING Phase 2

A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Treatment-Naive CLL

NCT02514083

ACTIVE NOT RECRUITING Phase 2

Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure

NCT02105766

ACTIVE NOT RECRUITING Phase 1

Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia

NCT01623167

ACTIVE NOT RECRUITING Phase 2

PCI-32765 for Special Cases of Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT01500733

ACTIVE NOT RECRUITING Phase 2

Eltrombopag for Moderate Aplastic Anemia

NCT01328587

ACTIVE NOT RECRUITING Phase 1

Haploidentical PBMC Transplant for Severe Congenital Anemias

NCT00977691

ACTIVE NOT RECRUITING

Hispanic Community Health Study / Study of Latinos

NCT02060344

ACTIVE NOT RECRUITING

The Jackson Heart Study of Cardiovascular Disease Among African Americans

NCT00005485

ACTIVE NOT RECRUITING

Cardiovascular Health Study (CHS)

NCT00005133

COMPLETED Phase 1

JAK/STAT Inhibition in CNS Kohlmeier-Degos Disease

NCT05998395

COMPLETED Phase 1

Treatment of Refractory Diamond-Blackfan Anemia With Eltrombopag

NCT04269889

COMPLETED

Patients' Long-Term Survival of Obstructive Hypertrophic Cardiomyopathy (HCM)

NCT04603521

COMPLETED NA

Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis

NCT04271735

COMPLETED

Extracellular RNAs in Relation to Cardiometabolic Risk

NCT03225196

COMPLETED Phase 2

Effect of Fish Oil Enriched In Omega-11 Fatty Acid On Lipoprotein Metabolism In Adults

NCT03043365

COMPLETED

Pathophysiology of Acute Pain in Patients With Sickle Cell Disease

NCT03049475

COMPLETED

Effect of Fasting and Refeeding on T-cell Fate

NCT02719899

COMPLETED Phase 2

Comparison of EPA and DHA-Rich Fish Oils on Lipoprotein Metabolism In Adults

NCT02514070

COMPLETED Phase 2

Allogeneic Hematopoietic Stem Cell Transplantation With Ixazomib for High Risk Multiple Myeloma (BMT CTN 1302)

NCT02440464

COMPLETED

dbGaP Protocol: Genetic Variants Associated With Pentalogy of Cantrell

NCT02430376

COMPLETED

Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary Fibrosis

NCT02315586

COMPLETED

Prospective International Study of Coronary Subtraction Using 320 Detector Row CT (CorSub)

NCT02303067

COMPLETED Phase 2

Complement Inhibition Using Eculizumab to Overcome Platelet Transfusion Refractoriness in Patients With Severe Thrombocytopenia

NCT02298933

COMPLETED

Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0

NCT02290392

COMPLETED Phase 1

Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access

NCT02280824

COMPLETED Phase 2

Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)

NCT02208037

COMPLETED Phase 1

Preventing Stem Cell Transplant Complications With a Blood Separator Machine

NCT01866839

COMPLETED

Pilot Study of Strength Testing in Overweight Women With or Without Insulin Resistance

NCT01862757

COMPLETED

Medical Arm of the Interagency Registry for Mechanically Assisted Circulatory Support

NCT01932294

COMPLETED

Longitudinal Observational Study of Severe Asthma

NCT01780142

COMPLETED Phase 2

Etidronate for Arterial Calcifications Due to Deficiency in CD73 (ACDC)

NCT01585402

Phase Distribution

PhaseTrial count
Phase 1 31
Phase 2 95
Phase 3 7
Phase 4 2

What the Pipeline for National Heart, Lung, and Blood Institute (NHLBI) Shows

According to the ClinicalTrials.gov registry, National Heart, Lung, and Blood Institute (NHLBI) is linked to 381 US clinical trials across every stage of research activity. Of those, 259 studies are currently recruiting — about 68% of the sponsor's indexed portfolio — and 103 are already marked complete, representing roughly 27% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

The phase mix for National Heart, Lung, and Blood Institute (NHLBI) reports 9 late-stage studies (Phase 3 and Phase 4 combined) and 126 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

The top therapeutic focus area indexed for National Heart, Lung, and Blood Institute (NHLBI) is Atherosclerosis with 12 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial