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NCT00116870 · ClinicalTrials.gov registry record · Phase 2

MARS - Monitored Atherosclerosis Regression Study

A Phase 2 study of Coronary Artery Disease and Atherosclerosis, sponsored by Merck Sharp & Dohme.

Completed
Registry status
Phase 2
Development phase
270
Enrollment target
1
Study location

NCT00116870: Completed Phase 2 study of Coronary Artery Disease and Atherosclerosis, sponsored by Merck Sharp & Dohme.

NCT00116870 is a Phase 2 study of Coronary Artery Disease and Atherosclerosis that has completed, run by Merck Sharp & Dohme. The registered enrollment target is 270 participants, below the 1,286-participant average among 219 other Coronary Artery Disease trials with a reported enrollment target (79% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT00116870, a Phase 2 study of Coronary Artery Disease and Atherosclerosis, has completed, sponsored by Merck Sharp & Dohme.

COMPLETED
Registry status
Phase 2
Development phase
270 participants
Enrollment target
1
Study location

Study Summary

The purpose of this study is to determine whether significant alterations in serum lipoproteins as provided by the drug lovastatin can substantially reduce atherosclerosis progression or even induce regression.

Interventions

  • DRUG lovastatin

Study Locations (1)

California

  • Atherosclerosis Research Unit, Division of Cardiovascular Medicine, Department of Medicine - Los Angeles

Trial Details

FieldValue
Enrollment Target 270 participants
Start Date 1985-06
Est. Completion 1992-02
Phase Phase 2
Merck Sharp & Dohme

558 total trials

What the finished NCT00116870 record still lists

NCT00116870 is an interventional study that assigns participants to a tested intervention. The registered 270 participants enrollment target is mid-sized for trials with a published cap, below the 1,286-participant average among 219 other Coronary Artery Disease trials with a reported enrollment target (79% lower).

The record links to 2 conditions, with Coronary Artery Disease appearing as the primary indexed condition, and to 1 intervention - of which lovastatin is the first listed.

NCT00116870 reports a single indexed study location in California.

Frequently Asked Questions

What is clinical trial NCT00116870 about?

NCT00116870 is a clinical study titled "MARS - Monitored Atherosclerosis Regression Study". The purpose of this study is to determine whether significant alterations in serum lipoproteins as provided by the drug lovastatin can substantially reduce atherosclerosis progression or even induce regression.

What is the current status of trial NCT00116870?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 270 participants. The study started on 1985-06. Estimated completion is 1992-02.

What conditions does trial NCT00116870 study?

This clinical trial studies the following conditions: Coronary Artery Disease, Atherosclerosis.

What interventions are being tested in trial NCT00116870?

The interventions under investigation include: lovastatin (DRUG).

Who is sponsoring clinical trial NCT00116870?

This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00116870 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Similar trials for Coronary Artery Disease

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT00116870's enrollment target sits among peer trials

270 109th of 219 higher than 111 of 219 other Coronary Artery Disease trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Coronary Artery Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Source: ClinicalTrials.gov NCT00116870, the US trial registry maintained by the National Library of Medicine. NCT00116870 (mid enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.