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2026 data Public-data reference. official source

Gout

Open-data reference.

35 US clinical trials · 8 currently recruiting

Active & Recent Trials

RECRUITING Phase 4 650 participants

Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout

Massachusetts General Hospital

NCT04875702

RECRUITING Phase 3 500 participants

A Study of Dotinurad Versus Allopurinol in Participants With Gout

Crystalys Therapeutics

NCT07089875

RECRUITING Phase 2 300 participants

Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare

Olatec Therapeutics

NCT05658575

RECRUITING NA 285 participants

Dose Response of Exercise for Arthritis Management

University of South Carolina

NCT06880653

RECRUITING NA 200 participants

Improving Gout Care After an ED Visit

University of Alabama at Birmingham

NCT06534554

RECRUITING Phase 2 150 participants

A Study to Investigate the Clinical Effect and the Safety of PRX-115 Infused Intravenously at Different Dosing Regimens, With and Without Methotrexate, Versus Placebo in Adults Gout Patients (RELEASE)

Protalix

NCT07280156

RECRUITING Phase 4 150 participants

Purified Cortrophin® Gel Efficacy and Safety Study of 2 Dose Levels in Patients With Acute Gout Flares

Massachusetts General Hospital

NCT07346079

RECRUITING Phase 2 25 participants

Evaluation of Efficacy and Safety of AR882 and XOI Co-administration in Uricase Treatment Failed Patients

Arthrosi Therapeutics

NCT07116746

ACTIVE NOT RECRUITING Phase 3 750 participants

Phase 3 Evaluation of Efficacy and Safety of AR882 in Gout Patients (AR882-301)

Arthrosi Therapeutics

NCT06846515

ACTIVE NOT RECRUITING Phase 3 750 participants

Phase 3 Evaluation of Efficacy and Safety of AR882 in Gout Patients (AR882-302)

Arthrosi Therapeutics

NCT06439602

ACTIVE NOT RECRUITING Phase 4 262 participants

A Trial to Investigate the Non-inferiority of Pegloticase Administered Every 4 Weeks (Q4W) With MTX Compared With Every 2 Weeks (Q2W) With MTX in Participants With Uncontrolled Refractory Gout

Amgen

NCT06229145

ACTIVE NOT RECRUITING NA 200 participants

Gout in the ED and Improving Research Participation

University of Alabama at Birmingham

NCT04075903

ACTIVE NOT RECRUITING Phase 2 87 participants

Dose Finding Study to Evaluate Safety and Efficacy of 3 Dosages of SAP 001.

Shanton Pharma Pte.

NCT05690204

ACTIVE NOT RECRUITING Phase 2 80 participants

Phase II Study to Evaluate Efficacy and Safety of D-0120 in Combination With Allopurinol in Subjects With Gout

InventisBio Co.

NCT05665699

ACTIVE NOT RECRUITING Phase 1 32 participants

PK and Safety Evaluation Study of SAP-001 in Adult Subjects With Normal and Impaired Renal Function

Shanton Pharma Pte.

NCT06729853

ACTIVE NOT RECRUITING 8 participants

Assessing the Role of the NLRP3 Inflammasome in Intercritical Gout

Attune Health Research

NCT04125459

COMPLETED 294,878 participants

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines - (DREAM) Probenecid vs Allopurinol

Brigham and Women's Hospital

NCT04746989

COMPLETED NA 1,463 participants

Virtual Gout Clinic

University of Alabama at Birmingham

NCT02790463

COMPLETED Phase 3 610 participants

Combining Lesinurad With Allopurinol in Inadequate Responders

Ardea Biosciences

NCT01493531

COMPLETED Phase 3 225 participants

Safety and Efficacy Study of PEG-uricase in the Treatment of Hyperuricemic Patients With Symptomatic Gout

Savient Pharmaceuticals

NCT00325195

COMPLETED Phase 3 151 participants

Open-Label Extension Study for Patients Who Completed a Phase 3 Double-blind Study of PEG-uricase for Symptomatic Gout

Savient Pharmaceuticals

NCT01356498

COMPLETED Phase 2 99 participants

Study to Evaluate the Urate-Lowering Activity and Safety of Oral BCX4208 Administered in Subjects With Gout

BioCryst Pharmaceuticals

NCT00985127

COMPLETED Phase 1 63 participants

Safety and Pharmacodynamics of SEL-212 (Pegsiticase + SEL-110) in Subjects With Elevated Blood Uric Acid Levels

Selecta Biosciences

NCT02648269

COMPLETED NA 44 participants

Novel Methods for Ascertainment of Gout Flares -A Pilot Study

University of Alabama at Birmingham

NCT02855437

COMPLETED NA 43 participants

The Diet Gout Trial

Johns Hopkins University

NCT03569020

COMPLETED Phase 1 31 participants

Mild, Moderate and Severe Renal Impairment Study

Ardea Biosciences

NCT02219516

COMPLETED Phase 1 24 participants

The Effect of Colchicine on the Pharmacokinetic Profile of LC350189 in Healthy Aldults.

LG Chem

NCT03927677

COMPLETED Phase 1 24 participants

NSAID Drug Interaction Study

Ardea Biosciences

NCT01884272

COMPLETED Phase 1 24 participants

The Effect of Naproxen on the Pharmacokinetic Profile of LC350189 in Healthy Adults

LG Chem

NCT04139824

COMPLETED Phase 1 22 participants

Safety and Pharmacodynamics of SEL-037 (Pegsiticase) in Subjects With Elevated Blood Uric Acid Levels

Selecta Biosciences

NCT02464605

COMPLETED Phase 1 20 participants

Open Label PK, PD and DDI of Dotinurad and Allopurinol in Gout Patients with Hyperuricemia

Urica Therapeutics

NCT06056570

COMPLETED Phase 2 20 participants

A Randomized, Double-Blind, Dose-Response Study of the Safety and Uric Acid Effects of Oral Ulodesine Added to Allopurinol in Subjects With Gout and Concomitant Moderate Renal Insufficiency

BioCryst Pharmaceuticals

NCT01407874

COMPLETED Phase 4 14 participants

Study of Pegloticase (KRYSTEXXA®) Plus Methotrexate in Patients With Uncontrolled Gout

Amgen

NCT03635957

COMPLETED NA 10 participants

Pharmacokinetics and Pharmacodynamics of Anthocyanins

Rutgers, The State University of New Jersey

NCT03650140

COMPLETED NA 6 participants

UR+AIMS Gout Wearable Skin Uric Acid Monitor Study

University of California, Los Angeles

NCT06187519

Phase Distribution

PhaseTrial count
Early Phase 1 8
Phase 2 7
Phase 3 6
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Gout Trial Landscape

ClinicalTrials.gov lists 35 US studies indexed under Gout, and 8 of those are currently open to recruitment — roughly 23% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Gout shows 10 late-stage studies (Phase 3 and Phase 4 combined) alongside 15 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Gout is led by University of Alabama at Birmingham with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 35 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Gout?

PlainTrial tracks 35 US clinical trials for Gout, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Gout?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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