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ClinicalTrials.gov 25 recruiting now later-stage tilt

Anesthesia: later-stage trial registry

25 of 58 indexed Anesthesia trials are currently recruiting, with more weight in Phase 3-4.

Corpus placement: #244 of 28,707 conditions by registered trial count.

58 US clinical trials · 25 currently recruiting · #244 of 28,707 conditions by registered trial count

Anesthesia: 58 US clinical trials tracked, 25 recruiting.

Anesthesia is the subject of 58 registered US clinical trials on ClinicalTrials.gov, 25 of them currently open to new participants. 16 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 4 of these trials.

Enrollment posture brief

Registry condition anesthesia

OPEN 25 | RECR 43% | LATE 16 | EARLY 10 | RANK #244 | SPON 4

Nearest open-share peer: Blood Pressure (43% recruiting · 102 trials)

Recurrent Acute Myeloid Leuk51.7%Anesthesia (this)43%Exercise41.4%Non-alcoholic Fatty Liver Di32.8%Diabetic Retinopathy25.9%
Open-enrollment share among volume-matched conditions near Anesthesia

Anesthesia lists 25 open slots (43% of 58 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Anesthesia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Anesthesia is recruiting above its size-band peers.

    25 of 58 indexed trials (43.1%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Anesthesia trials is spread across many organizations.

    Massachusetts General Hospital accounts for 4 of 58 trials (6.9%). 42 distinct sponsors appear on at least one study for this condition label.

  3. Most Anesthesia trials plan to enrol fewer than 100 people.

    Median target enrolment is 60 among the 58 trials that report a genuine target (sentinel values excluded). 39 of those (67.2%) plan for fewer than 100 participants.

  4. Anesthesia research is mostly interventional.

    45 interventional and 13 observational studies make up this index (77.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 15Phase 25Phase 35Phase 411

Open and recent trials

58 total, page 1 of 2

RECRUITING 5,000,000 participants

The Pediatric Anesthesia Quality Improvement Project

The Society for Pediatric Anesthesia

NCT00674388

RECRUITING 1,200,000 participants

The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes

Massachusetts General Hospital

NCT07022951

RECRUITING Phase 4 18,000 participants

The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery

University of California, San Francisco

NCT06802224

RECRUITING NA 13,000 participants

Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

Washington University School of Medicine

NCT05991453

RECRUITING 460 participants

Anesthetics and Analgesics in Children

Chi Dang Hornik

NCT03427736

RECRUITING Phase 4 260 participants

Total Intravenous Versus Inhalational Anesthesia- A Geriatric Anesthesia Study

Oregon Health and Science University

NCT06036095

RECRUITING 250 participants

A Study of Changes in Heart Function and Blood Flow in People Receiving Anesthesia

Memorial Sloan Kettering Cancer Center

NCT05954832

RECRUITING Phase 3 200 participants

Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)

University of Texas Southwestern Medical Center

NCT05358535

RECRUITING Phase 4 152 participants

Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine

The University of Texas Health Science Center, Houston

NCT06029049

RECRUITING Phase 3 100 participants

Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration

Massachusetts General Hospital

NCT07269808

RECRUITING Phase 4 100 participants

Oral Methadone in Cardiac Surgery

Mayo Clinic

NCT07221617

RECRUITING NA 94 participants

Enhanced Recovery After Surgery (ERAS) Total Knee Replacement (TKR) With a Transitional Pain Service

Hospital for Special Surgery, New York

NCT03747146

RECRUITING Phase 4 70 participants

Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection

University of California, San Diego

NCT04849455

RECRUITING Early Phase 1 60 participants

Remimazolam NeuroImaging

Keith M Vogt

NCT07290205

RECRUITING NA 60 participants

Pilot Feasibility Trial of the SafeLM Supraglottic Airway (SGA)

The University of Texas Health Science Center, Houston

NCT05989880

RECRUITING Early Phase 1 60 participants

Nitrous Oxide Neuroimaging

Keith M Vogt

NCT06702631

RECRUITING Early Phase 1 60 participants

Ketamine and Propofol NeuroImaging

Keith M Vogt

NCT07294092

RECRUITING NA 58 participants

Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery

Boston Children's Hospital

NCT06326983

RECRUITING Phase 4 56 participants

Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties

Melinda Seering

NCT05868330

RECRUITING 48 participants

Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients

Boston Children's Hospital

NCT03431064

RECRUITING Phase 1 40 participants

Prospective IR-led Sedation Feasibility

CAMC Health System

NCT07443254

RECRUITING NA 30 participants

Poke and a Placebo

University of Minnesota

NCT04497220

RECRUITING Phase 4 30 participants

Individual Cerebral Hemodynamic Oxygenation Relationships

Matthew Borzage

NCT04435834

RECRUITING 24 participants

Characterization of the Pudendal Nerve with Transvaginal Ultrasonography

University of Virginia

NCT06021782

RECRUITING NA 12 participants

REcovery From DEXmedetomidine-induced Unconsciousness

Massachusetts General Hospital

NCT06003127

ACTIVE NOT RECRUITING Phase 3 450 participants

A Study to Compare the Long-term Outcomes After Two Different Anaesthetics

Murdoch Childrens Research Institute

NCT03089905

ACTIVE NOT RECRUITING 80 participants

AVATAR Anesthesia Alternative in Pediatric Radiotherapy: A Multi-Center Study

Stanford University

NCT03991156

ACTIVE NOT RECRUITING 40 participants

Continuous Glucose Monitoring: A Pilot Study

Loma Linda University

NCT06614127

ACTIVE NOT RECRUITING NA 40 participants

Detecting Post-surgical Respiratory Compromise and Prompting Patients to Self-rescue: An Early Feasibility Study

University of Utah

NCT02962557

ACTIVE NOT RECRUITING NA 20 participants

Cataract Monitored Anesthesia Care (MAC) Feasibility Pilot Study

University of California, San Francisco

NCT06506669

ACTIVE NOT RECRUITING 20 participants

Correlate of Surface Electroencephalogram (EEG) With Implanted EEG Recordings (ECOG)

Stanford University

NCT03629743

ACTIVE NOT RECRUITING 16 participants

Assessment of Diagnostic Adequacy of AI-assisted Point-of-Care Echocardiography Among Anesthesiology Trainees

Loma Linda University

NCT06548373

COMPLETED NA 749 participants

Ultrasound-image Guided Versus Doppler Guided Versus Palpation Technique for Arterial Cannulation in Adults

University of Iowa

NCT01276171

COMPLETED NA 329 participants

Perioperative Audio for Anaesthesia

Brain.fm

NCT05291832

COMPLETED NA 211 participants

Evaluation of Bispectral Index (BIS™) and Levels of Sedation With Common Inhalational Anesthetics in Healthy Volunteers (OLIVER)

Medtronic - MITG

NCT04602546

COMPLETED NA 148 participants

Comparison of Ambu Auragain and I-Gel Supraglottic Airways in Adult Patients at an Ambulatory Surgery Center

University of Minnesota

NCT04286581

COMPLETED NA 108 participants

Comparison of Depth of Sedation Performance Between SedLine and Comparator Device During General Anesthesia

Masimo Corporation

NCT03865316

COMPLETED Phase 1 105 participants

Comparison of Procedural Sedation in TEE

University of Alabama at Birmingham

NCT06129188

COMPLETED Phase 4 100 participants

Papaverine vs Heparin for Peripheral Arterial Catheter Patency in Pediatric Patients

The University of Texas Health Science Center, Houston

NCT03894904

COMPLETED Phase 4 69 participants

Sugammadex Versus Neostigmine for Reversal of Rocuronium Neuromuscular

The Cleveland Clinic

NCT03322657

COMPLETED 63 participants

Brain Networks and Consciousness

University of Texas Southwestern Medical Center

NCT04502550

COMPLETED NA 61 participants

Measurement of Hemodynamic Variables Under Spinal Anesthesia With Varied Positioning

The University of Texas Medical Branch, Galveston

NCT02883075

COMPLETED Phase 4 60 participants

Comparing Local Anesthetics for TAP Block During Abdominally-based Free Flap for Breast Reconstruction

Vanderbilt University Medical Center

NCT03700970

COMPLETED NA 60 participants

Methadone in Ambulatory Surgery

Washington University School of Medicine

NCT02300077

COMPLETED Phase 3 59 participants

Impact of Intraoperative Fluid Management on Electrolyte and Acid-base Variables

Nationwide Children's Hospital

NCT03054922

COMPLETED NA 51 participants

Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs

Milton S. Hershey Medical Center

NCT02624050

COMPLETED Phase 2 48 participants

Dose-Ranging Study of Intranasal Kovacaine Mist in Pediatric Subjects

St. Renatus

NCT01701505

COMPLETED NA 40 participants

Educating Anesthesia Residents to Improve Perioperative Care for the Elderly

Duke University

NCT03008863

COMPLETED NA 40 participants

Acupuncture ACL (Anterior Cruciate Ligament)

Hospital for Special Surgery, New York

NCT03711734

COMPLETED Phase 2 36 participants

Investigating Near-Threshold Perception During Anesthetic Sedation

University of Michigan

NCT06403852

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Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 5
Phase 3 5
Phase 4 11

Named interventions

Most-linked intervention names on Anesthesia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Propofol Drug
6 trials
Dexmedetomidine Drug
4 trials
Peripheral Nerve Stimulation Device
3 trials
Morphine Drug
3 trials
Remimazolam Drug
3 trials
Ketamine Drug
3 trials
Sevoflurane Drug
2 trials
Midazolam Drug
2 trials

US sites by state

Facility locations filed on Anesthesia trials. A trial with sites in several states counts in each.

California 14 trials
Texas 11 trials
Massachusetts 10 trials
Pennsylvania 8 trials
New York 7 trials
North Carolina 7 trials
Ohio 5 trials
Missouri 5 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Anesthesia page

58 registered trials, 25 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Anesthesia condition card totals 58 registered trials; most-linked intervention Propofol; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.