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NCT06802224 · ClinicalTrials.gov registry record · Phase 4
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
A Phase 4 study of Anesthesia and Acute Kidney Injury (AKI), sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 18,000
- Enrollment target
- 8
- Study locations
NCT06802224 is a Phase 4 study of Anesthesia and Acute Kidney Injury (AKI) that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 18,000 participants, below the 109,094-participant average among 57 other Anesthesia trials with a reported enrollment target (84% lower). The trial reports 8 study locations across 6 states.
The verdict
NCT06802224, a Phase 4 study of Anesthesia and Acute Kidney Injury (AKI), is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 18,000 participants
- Enrollment target
- 8
- Study locations
Study Summary
Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient recovery. Anesthesiologists commonly administer medications called vasopressors to treat low blood pressure during surgery. These medications help raise the blood pressure back up to a safe range. Two vasopressor medications are commonly used for this purpose: norepinephrine and phenylephrine. Each of these medications has slightly different effects on the heart and blood vessels (cardiovascular system). It remains unknown which of these standard medications is better for treating low blood pressure during surgery. The goal of this clinical trial is to determine which of these two medications is better at preventing injury to the kidneys after major noncardiac surgery as well as other complications such as heart problems. Major surgeries are defined as those lasting at least two hours under general anesthesia. This trial will randomize about ten centers in North America to use either norepinephrine or phenylephrine as the primary medication to treat low blood pressure in adults undergoing major noncardiac surgery. Each hospital will prioritize one of the drugs each month, and the assigned drug will rotate each month at each hospital. No further participant involvement will be required as de-identified data are collected as part of standard medical care.
Conditions Studied
Interventions
- DRUG Norepinephrine
- DRUG Phenylephrine
Study Locations (8)
Michigan
- University of Michigan - Ann Arbor
- Henry Ford Health - Detroit
North Carolina
- Duke University Medical Center - Durham
- Wake Forest University School of Medicine - Winston-Salem
California
- University of California, San Francisco - San Francisco
Maryland
- University of Maryland - College Park
Texas
- UT Southwestern Medical Center - Dallas
Virginia
- University of Virginia - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18,000 participants |
| Start Date | 2025-04-01 |
| Est. Completion | 2028-07 |
| Phase | Phase 4 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06802224
The ClinicalTrials.gov registry entry for NCT06802224 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 18,000 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 109,094-participant average among 57 other Anesthesia trials with a reported enrollment target (84% lower). The listed sponsor is University of California, San Francisco, which has 1,713 total studies on file at ClinicalTrials.gov.
The record links to 7 conditions, with Anesthesia appearing as the primary indexed condition, and to 2 interventions - of which Norepinephrine is the first listed.
NCT06802224 reports 8 study locations spanning 6 distinct geographic areas - top geographies include Michigan, North Carolina, California.
Frequently Asked Questions
What is clinical trial NCT06802224 about?
NCT06802224 is a clinical study titled "The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery". Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient recovery. Anesthesiologists commonly administer medications called vasopre...
What is the current status of trial NCT06802224?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 18,000 participants. The study started on 2025-04-01. Estimated completion is 2028-07.
What conditions does trial NCT06802224 study?
This clinical trial studies the following conditions: Anesthesia, Acute Kidney Injury (AKI), Noncardiac Surgery, Surgery With General Anesthesia, Hypotension During Surgery.
What interventions are being tested in trial NCT06802224?
The interventions under investigation include: Norepinephrine (DRUG), Phenylephrine (DRUG).
Who is sponsoring clinical trial NCT06802224?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06802224 being conducted?
This trial has 8 study locations across California, Maryland, Michigan, North Carolina, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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