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NCT07022951 · ClinicalTrials.gov registry record

The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes

A clinical trial of Surgery and Anesthesia, sponsored by Massachusetts General Hospital.

Recruiting
Registry status
1,200,000
Enrollment target
1
Study location

NCT07022951: Recruiting study of Surgery and Anesthesia, sponsored by Massachusetts General Hospital.

NCT07022951 is a study of Surgery and Anesthesia that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 1,200,000 participants, above the 42,852-participant average among 120 other Surgery trials with a reported enrollment target (2700% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT07022951, a study of Surgery and Anesthesia, is actively recruiting participants, sponsored by Massachusetts General Hospital.

RECRUITING
Registry status
1,200,000 participants
Enrollment target
1
Study location

Study Summary

Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful. This study intends to characterize perioperative fasting practices and their potential effects on clinical outcomes through possible effects on patient well-being (anxiety, hunger, thirst), physiology (hypovolemia, hypotension), perioperative aspiration, etc. We hypothesized that in addition to known adverse effects on patients' well-being, prolonged preoperative fasting adversely affects circulating blood volume-related (hypotension, decreased urine output etc.) and glucose metabolism-related (e.g., hypo/hyperglycemia) perioperative physiology. Additional knowledge on the potential adverse effects of preoperative fasting will inform preoperative fasting policies and research interventions that are relevant to hundreds of millions of patients subjected to preoperative/preprocedural fasting worldwide each year.

Primary Outcome

The co-primary outcome of PONV is defined as administration ≥ 1 antiemetic drug within 12 h postoperatively.

Conditions Studied

Surgery Anesthesia Sedation Aspiration; Gastric Contents, Anesthesia Monitored Anesthesia Care Procedure Surgery, Day Surgery Scheduled Fasting Before Operation

Interventions

  • OTHER Preoperative fasting

Study Locations (1)

Massachusetts

  • Mass General Brigham - Boston

Trial Details

FieldValue
Enrollment Target 1,200,000 participants
Start Date 2016-01-01
Est. Completion 2030-12-31
Massachusetts General Hospital

2,032 total trials

What NCT07022951 shows while recruiting

NCT07022951 is an observational study that tracks outcomes without assigning an intervention. Its 1,200,000 participants enrollment target places it among the larger protocols in the corpus, above the 42,852-participant average among 120 other Surgery trials with a reported enrollment target (2700% higher).

The record links to 9 conditions, with Surgery appearing as the primary indexed condition, and to 1 intervention - of which Preoperative fasting is the first listed.

NCT07022951 reports a single indexed study location in Massachusetts.

Frequently Asked Questions

What is clinical trial NCT07022951 about?

NCT07022951 is a clinical study titled "The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes". Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful. This study intends to characterize perioperative fasting practices and their potential effects on clinical outcomes thr...

What is the current status of trial NCT07022951?

This trial is currently recruiting. The enrollment target is 1,200,000 participants. The study started on 2016-01-01. Estimated completion is 2030-12-31.

What conditions does trial NCT07022951 study?

This clinical trial studies the following conditions: Surgery, Anesthesia, Sedation, Aspiration; Gastric Contents, Anesthesia, Monitored Anesthesia Care.

What interventions are being tested in trial NCT07022951?

The interventions under investigation include: Preoperative fasting (OTHER).

Who is sponsoring clinical trial NCT07022951?

This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07022951 being conducted?

This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Surgery

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT07022951's enrollment target sits among peer trials

1,200,000 2nd of 120 the highest of 120 other Surgery trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Surgery trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT07022951

Source: ClinicalTrials.gov NCT07022951, the US trial registry maintained by the National Library of Medicine. NCT07022951 (large enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.