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NCT06702631 · ClinicalTrials.gov registry record · Early Phase 1
Nitrous Oxide Neuroimaging
A Early Phase 1 study of Pain and Anesthesia, sponsored by Keith M Vogt.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT06702631: Recruiting Early Phase 1 study of Pain and Anesthesia, sponsored by Keith M Vogt.
NCT06702631 is a Early Phase 1 study of Pain and Anesthesia that is actively recruiting participants, run by Keith M Vogt. The registered enrollment target is 60 participants, below the 304-participant average among 374 other Pain trials with a reported enrollment target (80% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06702631, a Early Phase 1 study of Pain and Anesthesia, is actively recruiting participants, sponsored by Keith M Vogt.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.
Primary Outcome
Event-related blood-oxygen level dependent Magnetic Resonance Imaging (MRI) responses will be determined. Z-scores will be calculated by linear regression of the task timing against the MRI signal time-course (MRI data is in arbitrary units with no maximum or minimum) at each voxel (single data point in brain). Primary outcome will be for the right insula. Z-score of 0 indicates no task-related changes. Z-scores further from zero indicate stronger correlation between functional MRI signal change
Conditions Studied
Interventions
- DRUG Nitrous oxide
- DEVICE Peripheral Nerve Stimulation
Study Locations (1)
Pennsylvania
- University of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-01-13 |
| Est. Completion | 2026-06-01 |
| Phase | Early Phase 1 |
What NCT06702631 shows while recruiting
NCT06702631 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 304-participant average among 374 other Pain trials with a reported enrollment target (80% lower).
The record links to 3 conditions, with Pain appearing as the primary indexed condition, and to 2 interventions - of which Nitrous oxide is the first listed.
NCT06702631 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06702631 about?
NCT06702631 is a clinical study titled "Nitrous Oxide Neuroimaging". The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will...
What is the current status of trial NCT06702631?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 60 participants. The study started on 2025-01-13. Estimated completion is 2026-06-01.
What conditions does trial NCT06702631 study?
This clinical trial studies the following conditions: Pain, Anesthesia, Amnesia.
What interventions are being tested in trial NCT06702631?
The interventions under investigation include: Nitrous oxide (DRUG), Peripheral Nerve Stimulation (DEVICE).
Who is sponsoring clinical trial NCT06702631?
This trial is sponsored by Keith M Vogt, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06702631 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06702631's enrollment target sits among peer trials
60 224th of 374 higher than 134 of 374 other Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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