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NCT03894904 · ClinicalTrials.gov registry record · Phase 4
Papaverine vs Heparin for Peripheral Arterial Catheter Patency in Pediatric Patients
A Phase 4 study of Anesthesia and Pediatrics, sponsored by The University of Texas Health Science Center, Houston.
- Completed
- Registry status
- Phase 4
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT03894904: Completed Phase 4 study of Anesthesia and Pediatrics, sponsored by The University of Texas Health Science Center, Houston.
NCT03894904 is a Phase 4 study of Anesthesia and Pediatrics that has completed, run by The University of Texas Health Science Center, Houston. The registered enrollment target is 100 participants, below the 109,408-participant average among 57 other Anesthesia trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03894904, a Phase 4 study of Anesthesia and Pediatrics, has completed, sponsored by The University of Texas Health Science Center, Houston.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to compare intraoperative papaverine plus heparin to heparin alone for prevention of arterial spasm and maintenance of patency of peripheral arterial catheters during surgery in pediatric patients. The hypothesis is that periodic, intraoperative small-volume boluses of diluted papaverine plus heparin in peripheral arterial catheters of pediatric patients will prevent arterial spasm and help maintain patency of arterial catheters during general anesthesia.
Primary Outcome
Optimal waveform was defined as easy aspiration of a blood sample (negative aspiration is easy and draws back freely without cavitation, and takes no more than 30 seconds to draw 1 mL), absence of color change at the catheter insertion site, and presence of a dicrotic notch in the arterial pressure waveform (a distinct dicrotic notch implies system has good resolution at higher frequencies and is not overdamped).
Conditions Studied
Interventions
- DRUG Papaverine
- DRUG Heparin
- DRUG Rescue papaverine, as needed
Study Locations (1)
Texas
- UT Health - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2019-04-01 |
| Est. Completion | 2020-10-10 |
| Phase | Phase 4 |
What the finished NCT03894904 record still lists
NCT03894904 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 109,408-participant average among 57 other Anesthesia trials with a reported enrollment target (100% lower).
The record links to 3 conditions, with Anesthesia appearing as the primary indexed condition, and to 3 interventions - of which Papaverine is the first listed.
NCT03894904 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT03894904 about?
NCT03894904 is a clinical study titled "Papaverine vs Heparin for Peripheral Arterial Catheter Patency in Pediatric Patients". The purpose of this study is to compare intraoperative papaverine plus heparin to heparin alone for prevention of arterial spasm and maintenance of patency of peripheral arterial catheters during surgery in pediatric patients. The hypothesis is that periodic, intraoperative small-volume boluses of d...
What is the current status of trial NCT03894904?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 100 participants. The study started on 2019-04-01. Estimated completion is 2020-10-10.
What conditions does trial NCT03894904 study?
This clinical trial studies the following conditions: Anesthesia, Pediatrics, Vasospasm.
What interventions are being tested in trial NCT03894904?
The interventions under investigation include: Papaverine (DRUG), Heparin (DRUG), Rescue papaverine, as needed (DRUG).
Who is sponsoring clinical trial NCT03894904?
This trial is sponsored by The University of Texas Health Science Center, Houston, which has 732 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03894904 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Anesthesia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03894904's enrollment target sits among peer trials
100 17th of 57 higher than 39 of 57 other Anesthesia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Anesthesia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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