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Diabetic Retinopathy: early-phase trial registry
15 of 58 indexed Diabetic Retinopathy trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #244 of 28,707 conditions by registered trial count.
58 US clinical trials · 15 currently recruiting · #244 of 28,707 conditions by registered trial count
Diabetic Retinopathy: 58 US clinical trials tracked, 15 recruiting.
Diabetic Retinopathy is the subject of 58 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is National Eye Institute (NEI), running 4 of these trials.
Enrollment posture brief
Registry condition diabetic-retinopathy
OPEN 15 | RECR 26% | LATE 8 | EARLY 21 | RANK #244 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Coronary Artery Disease (26% recruiting · 220 trials)
Diabetic Retinopathy lists 15 open slots (26% of 58 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Diabetic Retinopathy on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Diabetic Retinopathy is recruiting below its size-band peers.
15 of 58 indexed trials (25.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Diabetic Retinopathy trials is spread across many organizations.
National Eye Institute (NEI) accounts for 4 of 58 trials (6.9%). 45 distinct sponsors appear on at least one study for this condition label.
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Typical Diabetic Retinopathy enrolment sits around 178 participants.
Median target enrolment is 178 among the 58 trials that report a genuine target (sentinel values excluded). 20 of those (34.5%) plan for fewer than 100 participants.
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Diabetic Retinopathy splits between interventional and observational designs.
39 interventional and 19 observational studies make up this index (67.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
58 total, page 1 of 2
Village-Integrated Eye Worker Trial II
University of California, San Francisco
NCT03752840
Clinical Applications of Advanced Ophthalmic Imaging
University of Miami
NCT03135327
Video-based Patient Education Intervention for Diabetic Eye Screening in Latinx Communities
University of Wisconsin, Madison
NCT06257082
Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease
Johns Hopkins University
NCT04505618
Pivotal Trial of Automated Artificial Intelligence (AI) Based System for Early Diagnosis of Diabetic Retinopathy
iHealthScreen
NCT07151001
National Eye Institute Biorepository for Retinal Diseases
National Eye Institute (NEI)
NCT01496625
Fenofibrate for Prevention of DR Worsening
Jaeb Center for Health Research
NCT04661358
Intraoperative OCT Guidance of Intraocular Surgery II
Duke University
NCT03713268
Biomarker of Diabetic Retinopathy
Indiana University
NCT05079399
A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic Retinopathy
Boehringer Ingelheim
NCT06321302
Liver X Receptor (LXR) as a Novel Therapeutic Target in Diabetic Retinopathy (DR)
University of Alabama at Birmingham
NCT03403686
A Study to Evaluate the Efficacy and Safety of Orally Administered VX-01
Vantage Biosciences
NCT06770933
Sleep, Diabetic Retinopathy and Melatonin
University of Illinois at Chicago
NCT04547439
Human iPSC for Repair of Vasodegenerative Vessels in Diabetic Retinopathy
University of Alabama at Birmingham
NCT03403699
Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein Sodium
MediBeacon
NCT04008121
Implementation of Teleophthalmology in Urban Health Systems Study
University of Wisconsin, Madison
NCT05773495
Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT)
Columbia University
NCT04271709
Camera Qualification Study
Digital Diagnostics
NCT05808699
Predicting Diabetic Retinopathy From Risk Factor Data and Digital Retinal Images
Charles Drew University of Medicine and Science
NCT03694145
WF and PR OCTA in Diabetic Retinopathy
Oregon Health and Science University
NCT03922932
A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer Compared With Sham Treatment in Participants With Diabetic Retinopathy (DR)
Kodiak Sciences
NCT06270836
A Multicenter, Randomized Study in Participants With Diabetic Retinopathy Without Center-involved Diabetic Macular Edema To Evaluate the Efficacy, Safety, and Pharmacokinetics of Ranibizumab Delivered Via the Port Delivery System Relative to the Comparator Arm
Hoffmann-La Roche
NCT04503551
OCT Biomarkers for Diabetic Retinopathy
Oregon Health and Science University
NCT02330042
INflammatory MediatorS in the PathophysIology of Diabetic REtinopathy Study
Stephen J. Kim, MD
NCT04505566
Vascular Reparative Mechanism in Diabetes
University of Alabama at Birmingham
NCT02119689
4D-150 in Patients With Diabetic Macular Edema
4D Molecular Therapeutics
NCT05930561
A Study of PER-001 in Participants With Diabetic Retinopathy
Perfuse Therapeutics
NCT06003751
Long-Term Follow-up Study of ADVM-022 in DME (INFINITY-EXT)
Adverum Biotechnologies
NCT05607810
Clinical Trial of Autologous Intravitreal Bone-marrow CD34+ Stem Cells for Retinopathy
University of California, Davis
NCT01736059
Study to Evaluate the Effectiveness of a Program Developed to Improve Eye Care for Veterans With Diabetes
US Department of Veterans Affairs
NCT00119535
Assessment of EyeArt as an Automated Diabetic Retinopathy Screening Tool
Eyenuk
NCT03112005
Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage
Bausch & Lomb Incorporated
NCT00198510
Reduction in the Occurrence of Center-Involved Diabetic Macular Edema
Chromaderm
NCT00090519
Genetics and Markers of Degenerative and Inflammatory Eye Diseases
National Eye Institute (NEI)
NCT00647439
The Comparative Effectiveness of Telemedicine to Detect Diabetic Retinopathy
Legacy Health System
NCT01364129
Pediatric Type 1 Diabetes and Retinopathy
University of Florida
NCT02691312
RETeval Study for Diabetic Retinopathy
Inoveon Corporation
NCT01950663
Anti-VEGF Treatment for Prevention of PDR/DME
Jaeb Center for Health Research
NCT02634333
Thermal Screening for Early Diabetic Peripheral Neuropathy (DPN)
VisionQuest Biomedical
NCT03069729
Octreotide Acetate in Microspheres in Patients With Diabetic Retinopathy
Novartis
NCT00130845
PF-04523655 Dose Escalation Study, and Evaluation of PF-04523655 With/Without Ranibizumab in Diabetic Macular Edema (DME)
Quark Pharmaceuticals
NCT01445899
Levodopa for Diabetic Retinopathy
Emory University
NCT07444892
A Study to Investigate the Efficacy and Safety of RG7774 in Patients With Diabetes Mellitus Type 1 or Type 2 With Treatment-Naive Diabetic Retinopathy
Hoffmann-La Roche
NCT04265261
A Study to Evaluate THR-149 Treatment for Diabetic Macular Oedema
Oxurion
NCT04527107
A Phase 2 Evaluation of Anti-VEGF Therapy for Diabetic Macular Edema: Bevacizumab (Avastin)
Jaeb Center for Health Research
NCT00336323
Intravitreal v. Sub-tenon Injections of Triamcinolone Acetonide for Macular Edema in Retinal Disorders
National Eye Institute (NEI)
NCT00101764
Comparing Visual Acuity Measurements (How Well You Can See) Using a Standard ETDRS Chart & a Handheld ETDRS Chart
Julia Haller
NCT01622816
Comparing 3 Imaging Systems
University of Wisconsin, Madison
NCT05022615
Efficacy Study of Lucentis in the Treatment of Diabetic Macular Edema
Rocky Mountain Retina Consultants
NCT00387582
A Phase 1 Safety Study of TG100801 Eye Drops in Healthy Volunteers
TargeGen
NCT00414999
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 8 |
| Phase 2 | 13 |
| Phase 3 | 7 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Diabetic Retinopathy records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Diabetic Retinopathy trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Diabetic Retinopathy page
58 registered trials, 15 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 15 Diabetic Retinopathy trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Eye Institute (NEI) sponsors the most Diabetic Retinopathy trials on record, review their full trial history before evaluating a specific study. See National Eye Institute (NEI)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Diabetic Retinopathy condition card totals 58 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.