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Non-alcoholic Fatty Liver Disease clinical trials
18 of 51 indexed Non-alcoholic Fatty Liver Disease trials are currently recruiting.
51 US clinical trials · 18 currently recruiting
Non-alcoholic Fatty Liver Disease is the subject of 51 registered US clinical trials on ClinicalTrials.gov, 18 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 20 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), running 3 of these trials.
The research picture
Non-alcoholic Fatty Liver Disease has 51 registered US clinical trials, 18 of them open to new participants right now, about 35% of the total.
- 18
- recruiting participants now
- 35%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 3
- top sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active & Recent Trials
51 total, page 1 of 2
A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH
GlaxoSmithKline
NCT07221188
AdventHealth Research Institute Non-Alcoholic Fatty Liver Disease Biobank and Registry (AVAIL)
AdventHealth Translational Research Institute
NCT04807868
A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH
GlaxoSmithKline
NCT07221227
The Olmsted NAFLD Epidemiology Study (TONES)
Mayo Clinic
NCT04365855
Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease
Brigham and Women's Hospital
NCT05728697
Fibrosis Lessens After Metabolic Surgery
Ali Aminian
NCT06374875
Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT03884075
Moderately Carbohydrate-restricted Diet to Treat NAFLD in Adolescents
University of Alabama at Birmingham
NCT05268042
The Gut, Liver And Metabolome in Human Immunodeficiency Virus and Non Alcoholic Fatty Liver Disease
Vanderbilt University Medical Center
NCT06113003
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)
Bettina Mittendorfer
NCT06571474
Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease
Yale University
NCT05067621
Quantifying Hepatic Mitochondrial Fluxes in Humans
The University of Texas Health Science Center at San Antonio
NCT05305287
A Prospective, Randomized, Open Label Trial of Two Doses of Oral Betaine
Southern California Institute for Research and Education
NCT03073343
Impact of Soymilk on Liver Disease Severity of Children With Non-alcoholic Fatty Liver Disease (NAFLD)
Marialena Mouzaki
NCT06133101
Mechanisms of SGLT2 Inhibition in Pediatric Steatotic Liver Disease
Justin Ryder
NCT06355310
Diet and Meal Timing in Patients With Metabolic Dysfunction Associated Steatoic Liver Disease
Weill Medical College of Cornell University
NCT05332613
Human Models of Selective Insulin Resistance: Alpelisib, Part I
Columbia University
NCT06354088
Intermittent Fasting for NAFLD in Adults
Massachusetts General Hospital
NCT04899102
A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)
Madrigal Pharmaceuticals
NCT04951219
Phase 2b Study of GSK4532990 in Adults With NASH
GlaxoSmithKline
NCT05583344
Ph 2 Study of the Safety and Efficacy of Three HU6 Dose Levels and Placebo in Nonalcoholic Steatohepatitis
Rivus Pharmaceuticals
NCT05979779
Role of Immune System in Obesity-related Inflammation and Cardiometabolic Risk
Washington University School of Medicine
NCT01104220
Prevention of NAFLD in Hispanic Children
Emory University
NCT05292352
A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)
Merck Sharp & Dohme
NCT06465186
MN-001 in Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus, and Hypertriglyceridemia
MediciNova
NCT05464784
Microbiome-Mediated Gut Dysfunction in Non-Alcoholic Fatty Liver Disease
AdventHealth Translational Research Institute
NCT05209100
A Study to Evaluate the Safety, Tolerability & Efficacy of MSDC-0602K in Patients With NASH
Cirius Therapeutics
NCT02784444
Genetics of Fatty Liver Disease in Children
Yale University
NCT01966627
Effect of Patient Demographics, Comorbidities, and Medications on Severity of NASH Fibrosis
Methodist Health System
NCT05357352
Nonalcoholic Fatty Liver Disease and Atherosclerotic Risk in Children
Augusta University
NCT02383485
Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)
Merck Sharp & Dohme
NCT06482112
Saroglitazar Magnesium in Patients With Nonalcoholic Fatty Liver Disease and/or Nonalcoholic Steatohepatitis
Zydus Therapeutics
NCT03061721
A Study to Test How Well Different Doses of BI 3006337 Are Tolerated by People With Overweight or Obesity and With Fatty Liver Disease
Boehringer Ingelheim
NCT05970640
Assessment of Insulin Resistance, NAFLD, Predictors of CV Morbidity, and Subcutaneous Adipose and Visceral Adipose Gene Expression in Patients Undergoing Gastric Bypass Surgery
University of Massachusetts, Worcester
NCT01007955
Determination of the Effect of Extreme Dietary Carbohydrate Restriction on Hepatic Glucose Production
University of Texas Southwestern Medical Center
NCT01262326
Phase I Trial of Silymarin for Chronic Liver Diseases
National Center for Complementary and Integrative Health (NCCIH)
NCT00389376
Healthy Liver - Healthy Brain
University of Texas at Austin
NCT05216796
6-week Safety and PD Study in Adults With NAFLD
Pfizer
NCT03256526
Sitagliptin Versus Placebo in the Treatment of Non-alcoholic Fatty Liver Disease
University of California, San Diego
NCT01963845
Intra-Individual Reproducibility of the Non-Invasive Assessment of the Portal Circulation
HepQuant
NCT01579162
Single Ascending Dose of AMG 609 in Participants With Non-alcoholic Fatty Liver Disease
Amgen
NCT04857606
De Novo Lipogenesis, Lipid and Carbohydrate Metabolism in Non-alcoholic Fatty Liver Disease
University of California, San Francisco
NCT00714129
Effect of Macrocomposition on Nonalcoholic Fatty Liver Disease (NAFLD) in Bariatric Surgery Candidates
University of Michigan
NCT00887393
Effect of Omega-3 PUFA Supplementation in NAFLD Patients
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00230113
Early Intervention and Prevention of Non-Alcoholic Fatty Liver Disease in Adolescents
University of Wisconsin, Madison
NCT02116192
Pilot of Lifestyle Behavior Intervention for Non-Alcoholic Fatty Liver Disease
The University of Texas Health Science Center, Houston
NCT05200585
Autonomic Dysfunction in Non-Alcoholic Fatty Liver Disease
Virginia Commonwealth University
NCT02132780
The Effect of an RBAC Supplement (BRM4) on NAFLD
University of Miami
NCT02568787
Endoscopic Ultrasound(EUS)-Guided TRUCUT Biopsy (EUS-TCB) of Suspected Nonalcoholic Fatty Liver Disease(NAFLD.)
Indiana University
NCT00586313
Iron Depletion Therapy for Type 2 DM and NAFLD
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00230087
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 15 |
| Phase 3 | 3 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Non-alcoholic Fatty Liver Disease Trial Landscape
51 indexed Non-alcoholic Fatty Liver Disease studies · 18 recruiting (35%).
Phase mix: 5 late (III/IV) vs 20 early (I/II).
Top sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Non-alcoholic Fatty Liver Disease?
PlainTrial tracks 51 US clinical trials for Non-alcoholic Fatty Liver Disease, of which 18 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Non-alcoholic Fatty Liver Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.