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ClinicalTrials.gov 18 recruiting now official registry

Non-alcoholic Fatty Liver Disease clinical trials

18 of 51 indexed Non-alcoholic Fatty Liver Disease trials are currently recruiting.

51 US clinical trials · 18 currently recruiting

Non-alcoholic Fatty Liver Disease is the subject of 51 registered US clinical trials on ClinicalTrials.gov, 18 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 20 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), running 3 of these trials.

The research picture

Non-alcoholic Fatty Liver Disease has 51 registered US clinical trials, 18 of them open to new participants right now, about 35% of the total.

18
recruiting participants now
35%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
3
top sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Phase 15Phase 215Phase 33Phase 42

Active & Recent Trials

51 total, page 1 of 2

RECRUITING Phase 3 1,250 participants

A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH

GlaxoSmithKline

NCT07221188

RECRUITING 1,250 participants

AdventHealth Research Institute Non-Alcoholic Fatty Liver Disease Biobank and Registry (AVAIL)

AdventHealth Translational Research Institute

NCT04807868

RECRUITING Phase 3 1,200 participants

A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH

GlaxoSmithKline

NCT07221227

RECRUITING NA 800 participants

The Olmsted NAFLD Epidemiology Study (TONES)

Mayo Clinic

NCT04365855

RECRUITING 150 participants

Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease

Brigham and Women's Hospital

NCT05728697

RECRUITING Phase 4 120 participants

Fibrosis Lessens After Metabolic Surgery

Ali Aminian

NCT06374875

RECRUITING Phase 2 84 participants

Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT03884075

RECRUITING NA 80 participants

Moderately Carbohydrate-restricted Diet to Treat NAFLD in Adolescents

University of Alabama at Birmingham

NCT05268042

RECRUITING Early Phase 1 63 participants

The Gut, Liver And Metabolome in Human Immunodeficiency Virus and Non Alcoholic Fatty Liver Disease

Vanderbilt University Medical Center

NCT06113003

RECRUITING 60 participants

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

Bettina Mittendorfer

NCT06571474

RECRUITING Phase 2 60 participants

Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

Yale University

NCT05067621

RECRUITING Phase 4 60 participants

Quantifying Hepatic Mitochondrial Fluxes in Humans

The University of Texas Health Science Center at San Antonio

NCT05305287

RECRUITING NA 48 participants

A Prospective, Randomized, Open Label Trial of Two Doses of Oral Betaine

Southern California Institute for Research and Education

NCT03073343

RECRUITING Phase 2 44 participants

Impact of Soymilk on Liver Disease Severity of Children With Non-alcoholic Fatty Liver Disease (NAFLD)

Marialena Mouzaki

NCT06133101

RECRUITING Phase 2 40 participants

Mechanisms of SGLT2 Inhibition in Pediatric Steatotic Liver Disease

Justin Ryder

NCT06355310

RECRUITING NA 40 participants

Diet and Meal Timing in Patients With Metabolic Dysfunction Associated Steatoic Liver Disease

Weill Medical College of Cornell University

NCT05332613

RECRUITING Phase 1 32 participants

Human Models of Selective Insulin Resistance: Alpelisib, Part I

Columbia University

NCT06354088

RECRUITING NA 25 participants

Intermittent Fasting for NAFLD in Adults

Massachusetts General Hospital

NCT04899102

ACTIVE NOT RECRUITING Phase 3 1,000 participants

A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)

Madrigal Pharmaceuticals

NCT04951219

ACTIVE NOT RECRUITING Phase 2 284 participants

Phase 2b Study of GSK4532990 in Adults With NASH

GlaxoSmithKline

NCT05583344

ACTIVE NOT RECRUITING Phase 2 219 participants

Ph 2 Study of the Safety and Efficacy of Three HU6 Dose Levels and Placebo in Nonalcoholic Steatohepatitis

Rivus Pharmaceuticals

NCT05979779

ACTIVE NOT RECRUITING NA 144 participants

Role of Immune System in Obesity-related Inflammation and Cardiometabolic Risk

Washington University School of Medicine

NCT01104220

ACTIVE NOT RECRUITING NA 103 participants

Prevention of NAFLD in Hispanic Children

Emory University

NCT05292352

ACTIVE NOT RECRUITING Phase 2 80 participants

A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)

Merck Sharp & Dohme

NCT06465186

ACTIVE NOT RECRUITING Phase 2 40 participants

MN-001 in Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus, and Hypertriglyceridemia

MediciNova

NCT05464784

ACTIVE NOT RECRUITING 38 participants

Microbiome-Mediated Gut Dysfunction in Non-Alcoholic Fatty Liver Disease

AdventHealth Translational Research Institute

NCT05209100

COMPLETED Phase 2 392 participants

A Study to Evaluate the Safety, Tolerability & Efficacy of MSDC-0602K in Patients With NASH

Cirius Therapeutics

NCT02784444

COMPLETED 381 participants

Genetics of Fatty Liver Disease in Children

Yale University

NCT01966627

COMPLETED 263 participants

Effect of Patient Demographics, Comorbidities, and Medications on Severity of NASH Fibrosis

Methodist Health System

NCT05357352

COMPLETED NA 175 participants

Nonalcoholic Fatty Liver Disease and Atherosclerotic Risk in Children

Augusta University

NCT02383485

COMPLETED Phase 2 124 participants

Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)

Merck Sharp & Dohme

NCT06482112

COMPLETED Phase 2 106 participants

Saroglitazar Magnesium in Patients With Nonalcoholic Fatty Liver Disease and/or Nonalcoholic Steatohepatitis

Zydus Therapeutics

NCT03061721

COMPLETED Phase 1 64 participants

A Study to Test How Well Different Doses of BI 3006337 Are Tolerated by People With Overweight or Obesity and With Fatty Liver Disease

Boehringer Ingelheim

NCT05970640

COMPLETED 61 participants

Assessment of Insulin Resistance, NAFLD, Predictors of CV Morbidity, and Subcutaneous Adipose and Visceral Adipose Gene Expression in Patients Undergoing Gastric Bypass Surgery

University of Massachusetts, Worcester

NCT01007955

COMPLETED NA 60 participants

Determination of the Effect of Extreme Dietary Carbohydrate Restriction on Hepatic Glucose Production

University of Texas Southwestern Medical Center

NCT01262326

COMPLETED Phase 1 56 participants

Phase I Trial of Silymarin for Chronic Liver Diseases

National Center for Complementary and Integrative Health (NCCIH)

NCT00389376

COMPLETED NA 55 participants

Healthy Liver - Healthy Brain

University of Texas at Austin

NCT05216796

COMPLETED Phase 2 53 participants

6-week Safety and PD Study in Adults With NAFLD

Pfizer

NCT03256526

COMPLETED Phase 2 50 participants

Sitagliptin Versus Placebo in the Treatment of Non-alcoholic Fatty Liver Disease

University of California, San Diego

NCT01963845

COMPLETED NA 48 participants

Intra-Individual Reproducibility of the Non-Invasive Assessment of the Portal Circulation

HepQuant

NCT01579162

COMPLETED Phase 1 47 participants

Single Ascending Dose of AMG 609 in Participants With Non-alcoholic Fatty Liver Disease

Amgen

NCT04857606

COMPLETED NA 41 participants

De Novo Lipogenesis, Lipid and Carbohydrate Metabolism in Non-alcoholic Fatty Liver Disease

University of California, San Francisco

NCT00714129

COMPLETED NA 31 participants

Effect of Macrocomposition on Nonalcoholic Fatty Liver Disease (NAFLD) in Bariatric Surgery Candidates

University of Michigan

NCT00887393

COMPLETED Phase 2 30 participants

Effect of Omega-3 PUFA Supplementation in NAFLD Patients

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00230113

COMPLETED NA 28 participants

Early Intervention and Prevention of Non-Alcoholic Fatty Liver Disease in Adolescents

University of Wisconsin, Madison

NCT02116192

COMPLETED NA 27 participants

Pilot of Lifestyle Behavior Intervention for Non-Alcoholic Fatty Liver Disease

The University of Texas Health Science Center, Houston

NCT05200585

COMPLETED 25 participants

Autonomic Dysfunction in Non-Alcoholic Fatty Liver Disease

Virginia Commonwealth University

NCT02132780

COMPLETED NA 23 participants

The Effect of an RBAC Supplement (BRM4) on NAFLD

University of Miami

NCT02568787

COMPLETED NA 21 participants

Endoscopic Ultrasound(EUS)-Guided TRUCUT Biopsy (EUS-TCB) of Suspected Nonalcoholic Fatty Liver Disease(NAFLD.)

Indiana University

NCT00586313

COMPLETED Phase 2 15 participants

Iron Depletion Therapy for Type 2 DM and NAFLD

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00230087

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Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 15
Phase 3 3
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Non-alcoholic Fatty Liver Disease Trial Landscape

51 indexed Non-alcoholic Fatty Liver Disease studies · 18 recruiting (35%).

Phase mix: 5 late (III/IV) vs 20 early (I/II).

Top sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Non-alcoholic Fatty Liver Disease?

PlainTrial tracks 51 US clinical trials for Non-alcoholic Fatty Liver Disease, of which 18 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Non-alcoholic Fatty Liver Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.