Nationwide Children's Hospital
Trial Pipeline
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
NCT06333899
ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas
NCT06838676
Observation Study in Patients Age 0-5 Years With LAMA2-related Congenital Muscular Dystrophy
NCT06503367
Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells
NCT04254419
Pediatric Cochlear Implant Remote Programming and Assessment
NCT07035873
Preparing for Life and Academics for Young Childhood Cancer Survivors
NCT06769334
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
NCT05843253
Targeted Pediatric High-Grade Glioma Therapy
NCT05839379
PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma
NCT05096481
Applying Directly Observed Therapy to Hydroxyurea to Realize Effectiveness
NCT06264700
GERD Infant Feeding Therapeutics Trial (GIFT Trial)
NCT06114836
Improving Status Epilepticus Treatment Times
NCT06194747
αβT Cell/CD19+ B Cell Depletion for Alternative Donor Allogeneic Hematopoietic Cell Transplantation (HSCT)
NCT06082947
DOSC and Association With Neighborhood Opportunity: Phase II
NCT05939570
MEKTOVI® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma
NCT05286788
Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants
NCT05547165
ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma
NCT05233397
Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors
NCT05278208
A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue
NCT05634369
NK Cells Infusions With Irinotecan, Temozolomide, and Dinutuximab
NCT04211675
A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors
NCT05135975
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
NCT05267821
Safety and Efficacy of Expanded, Universal Donor Natural Killer Cells for Relapsed/Refractory AML
NCT05503134
Pilot Study of Haploidentical Donor Adenovirus Specific T-lymphocytes to Treat Refractory Adenovirus Infections
NCT04722029
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion
NCT04655404
Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts
NCT04467671
Early Predictors of Necrotizing Enterocolitis in Neonates
NCT03210831
Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease
NCT03622359
Genetics of Congenital Heart Disease
NCT01192048
Metabolomic Profiling of Racial Disparity
NCT06266429
Regional Anesthesia EMG Study
NCT06287151
VR-PAT for Pain and Anxiety Management During Pediatric Dermatologic Laser Procedures
NCT05645224
Evaluating an Intervention to Prevent Overdoses in Rural and Urban Counties
NCT05463341
Natural History Study of Patients With VCP-related Disease
NCT04823143
Early Prediction of Spontaneous Patent Ductus Arteriosus (PDA) Closure and PDA-Associated Outcomes
NCT03782610
GM-CSF for Reversal of immunopAralysis in pediatriC sEpsis-induced MODS Study
NCT03769844
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
NCT03605550
Haploidentical Hematopoietic Cell Transplantation for Children With Hematologic Malignancies and Myelodysplasia
NCT03431090
Characterization of Clinical Skeletal and Cardiac Impairment in Carriers of DMD and BMD
NCT02972580
MIBG Therapy for Patients With MIBG Avid Tumors
NCT02378428
Preoperative Survey to Evaluate Patient Allergy
NCT05670756
Baclofen for Children With Rumination Syndrome
NCT05975684
An Immediate Functional Progression Program for Adolescent Athletes With Spondylolysis
NCT05505981
Parental Perceptions on Prescription Opioid Use
NCT05344118
Decreasing Antibiotic Duration for Skin and Soft Tissue Infection Using Behavioral Economics in Primary Care
NCT05226260
VR for Burn Dressing Changes at Home
NCT04548635
VR for Pain Management During Adult Burn Dressing Change
NCT04545229
Comparison of Blood Pressure Measurements in Upper and Lower Extremities in Children Under General Anesthesia
NCT03220906
Impact of Intraoperative Fluid Management on Electrolyte and Acid-base Variables
NCT03054922
Feasibility of Using Functional Progression to Guide the Treatment of Adolescent Low Back Pain
NCT02861456
Evaluation of a Treatment Algorithm for Patients With Patellofemoral Pain Syndrome
NCT02461095
Rest Before Physical Therapy in Adolescents With Active Spondylolysis and Spondylolisthesis
NCT02332200
Qualitative Sweat Distribution During Tilt Table Procedure
NCT02329548
Virtual Temporal Bone Surgery: Defining and Translating Metrics
NCT01493765
Neuronal Ceroid Lipofuscinosis and Associated Sleep Abnormalities
NCT01966757
Tranexamic Acid in Adolescents With Heavy Menstrual Bleeding
NCT01846507
Pilot Trial of Phototherapy for Acute Depression in Hospitalized Cystic Fibrosis Patients
NCT01822197
Abdominal and Lower Extremity Compression During Tilt Table Testing in Adolescent POTS Patients
NCT01795469
Effect of Vitamin D on the Honeymoon Period in Children and Adolescents With Type 1 Diabetes
NCT01724190
Changes in Tissue Oxygenation Following Regional Anesthesia
NCT01418690
Sedation During Muscle Biopsy in Patients With Duchenne Muscular Dystrophy
NCT01645098
Accuracy of Using the CPAP Technique to Eliminate Air Leak and Prevent Excessive Endotracheal Tube Cuff Pressures
NCT01384318
Use of a Multimedia Presentation for Informed Consent
NCT01955070
CNAP™ Monitor Study
NCT01356082
Retrospective Femoral Nerve Block Study
NCT01293136
Impact of Using a Cuffed Endotracheal Tube on Limiting the Risk of Airway Fire
NCT01285804
Dexmedetomidine Versus Fentanyl Following Pressure Equalization Tube Placement
NCT01188551
Masimo CO-Oximeter Study
NCT01184521
Repeated Infusions of Mesenchymal Stromal Cells in Children With Osteogenesis Imperfecta
NCT01061099
Reducing Antipsychotic-Induced Weight Gain in Children With Metformin
NCT01231074
Use of an Ambulatory Capsule to Characterize Gastrointestinal Pressure Patterns in Children
NCT01026922
Measures to Lower the Stress Response in Pediatric Cardiac Surgery
NCT00848393
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 70 |
| Phase 2 | 66 |
| Phase 3 | 2 |
| Phase 4 | 2 |
Therapeutic Areas
What the Pipeline for Nationwide Children's Hospital Shows
According to the ClinicalTrials.gov registry, Nationwide Children's Hospital is linked to 239 US clinical trials across every stage of research activity. Of those, 196 studies are currently recruiting — about 82% of the sponsor's indexed portfolio — and 32 are already marked complete, representing roughly 13% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
The phase mix for Nationwide Children's Hospital reports 4 late-stage studies (Phase 3 and Phase 4 combined) and 136 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
The top therapeutic focus area indexed for Nationwide Children's Hospital is High Grade Glioma with 8 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology — how this data is sourced, computed, and verified.