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NCT06639464 · ClinicalTrials.gov registry record · Phase 2

Semaglutide for Helping Opioid Recovery

A Phase 2 study of Opioid Use Disorder, sponsored by Brigham and Women's Hospital.

Recruiting
Registry status
Phase 2
Development phase
46
Enrollment target
1
Study location

NCT06639464 is a Phase 2 study of Opioid Use Disorder that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 46 participants, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06639464, a Phase 2 study of Opioid Use Disorder, is actively recruiting participants, sponsored by Brigham and Women's Hospital.

RECRUITING
Registry status
Phase 2
Development phase
46 participants
Enrollment target
1
Study location

Study Summary

The is a pilot, 12-week, double-blind, placebo-controlled, randomized trial of individuals with opioid use disorder (OUD) newly initiating buprenorphine to receive either weekly injections of semaglutide (n=23) or matching placebo (n=23). The primary aim is to determine the effects of semaglutide on cue-reactivity among individuals with OUD. The secondary aim is to assess the preliminary efficacy, safety, and tolerability of semaglutide for OUD.

Conditions Studied

Opioid Use Disorder

Interventions

  • OTHER Placebo
  • DRUG Semaglutide

Study Locations (1)

Massachusetts

  • Brigham and Women's Hospital - Boston

Trial Details

FieldValue
Enrollment Target 46 participants
Start Date 2025-06-02
Est. Completion 2026-08-31
Phase Phase 2

Sponsor

Brigham and Women's Hospital

937 total trials

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What the Registry Record Tells You About NCT06639464

The ClinicalTrials.gov registry entry for NCT06639464 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 46 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (99% lower). The listed sponsor is Brigham and Women's Hospital, which has 937 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Opioid Use Disorder appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT06639464 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.

Frequently Asked Questions

What is clinical trial NCT06639464 about?

NCT06639464 is a clinical study titled "Semaglutide for Helping Opioid Recovery". The is a pilot, 12-week, double-blind, placebo-controlled, randomized trial of individuals with opioid use disorder (OUD) newly initiating buprenorphine to receive either weekly injections of semaglutide (n=23) or matching placebo (n=23). The primary aim is to determine the effects of semaglutide on...

What is the current status of trial NCT06639464?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 46 participants. The study started on 2025-06-02. Estimated completion is 2026-08-31.

What conditions does trial NCT06639464 study?

This clinical trial studies the following conditions: Opioid Use Disorder.

What interventions are being tested in trial NCT06639464?

The interventions under investigation include: Placebo (OTHER), Semaglutide (DRUG).

Who is sponsoring clinical trial NCT06639464?

This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06639464 being conducted?

This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.