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NCT06933706 · ClinicalTrials.gov registry record · Phase 2
Losartan to Improve Outcomes After Multi-ligament Knee Injury
A Phase 2 study of Multi-ligament Knee Injury, sponsored by Brigham and Women's Hospital.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 90
- Enrollment target
- 3
- Study locations
NCT06933706 is a Phase 2 study of Multi-ligament Knee Injury that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 90 participants. The trial reports 3 study locations across 3 states.
The verdict
NCT06933706, a Phase 2 study of Multi-ligament Knee Injury, is actively recruiting participants, sponsored by Brigham and Women's Hospital.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 90 participants
- Enrollment target
- 3
- Study locations
Study Summary
Multi-ligament knee injuries (MLKIs) can occur during military training, sports injuries, or traumatic events such as motor vehicle accidents and can be devastating events. These complex injuries involving disruption of 2 or more ligaments often coincide with injuries to arteries, nerves, tendons, menisci, and/or fractures and can be devastating events. MLKIs often require complex treatments nearly 2 in 5 patients suffer complications after surgery. Loss of knee range of motion is the most common complication and is associated with military separation. There are also long-term effects of motion loss, as the need for motion-restoring surgery after MLKI is associated with an increased risk of osteoarthritis within 5 years of surgery. A person's ability to perform both activities of daily living and higher demand physical activities is often impaired both in the short and long term. In fact, only 1 in 3 people return to high-level sport after MLKI. The purpose of this translational randomized clinical trial is to determine if a 30-day course of oral Losartan improves a person's ability to return to work or sport, range of motion and strength, and reduce knee inflammation in the first year after surgical treatment of an MLKI.
Conditions Studied
Interventions
- DRUG losartan 25 mg
- OTHER Placebo capsule
Study Locations (3)
Kentucky
- University of Kentucky - Lexington
Maryland
- Walter Reed National Military Medical Center - Bethesda
Massachusetts
- Mass General Brigham - Foxborough
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2025-10-01 |
| Est. Completion | 2029-09-30 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06933706
The ClinicalTrials.gov registry entry for NCT06933706 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 90 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Brigham and Women's Hospital, which has 937 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Multi-ligament Knee Injury appearing as the primary indexed condition, and to 2 interventions - of which losartan 25 mg is the first listed.
NCT06933706 reports 3 study locations spanning 3 distinct geographic areas - top geographies include Kentucky, Maryland, Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06933706 about?
NCT06933706 is a clinical study titled "Losartan to Improve Outcomes After Multi-ligament Knee Injury". Multi-ligament knee injuries (MLKIs) can occur during military training, sports injuries, or traumatic events such as motor vehicle accidents and can be devastating events. These complex injuries involving disruption of 2 or more ligaments often coincide with injuries to arteries, nerves, tendons, m...
What is the current status of trial NCT06933706?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 90 participants. The study started on 2025-10-01. Estimated completion is 2029-09-30.
What conditions does trial NCT06933706 study?
This clinical trial studies the following conditions: Multi-ligament Knee Injury.
What interventions are being tested in trial NCT06933706?
The interventions under investigation include: losartan 25 mg (DRUG), Placebo capsule (OTHER).
Who is sponsoring clinical trial NCT06933706?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06933706 being conducted?
This trial has 3 study locations across Kentucky, Maryland, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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