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Rheumatoid Arthritis clinical trials
37 of 199 indexed Rheumatoid Arthritis trials are currently recruiting.
199 US clinical trials · 37 currently recruiting
Rheumatoid Arthritis is the subject of 199 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 77 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 13 of these trials.
The research picture
Rheumatoid Arthritis has 199 registered US clinical trials, 37 of them open to new participants right now, about 19% of the total.
- 37
- recruiting participants now
- 19%
- of trials open to enrollment
- 32
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Zimmer Biomet
Active & Recent Trials
199 total, page 1 of 4
Exactech Shoulder Post Market Clinical Follow-up Study
Exactech
NCT05603728
Prospective, Multi-Center, Observational, Whole Blood Specimen Collection Study in Participants with Rheumatoid Arthritis with Inadequate Response or Intolerance to a DMARD Starting a New BDMARD or TsDMARD Treatment +/- CsDMARD
Aqtual
NCT05936970
PREDICT Therapy Selection for JAK, T-cell, or IL-6 Inhibitor Therapies Using a Molecular Signature Response Classifier (PREDICT)
Scipher Medicine
NCT06390709
Maternal Autoimmune Disease Research Alliance (MADRA) Registry
Duke University
NCT03276923
Ra-pro Pragmatic Trial
University of Alabama at Birmingham
NCT04692493
Physica System Total Knee Replacement Registry Study
Limacorporate S.p.a
NCT03048201
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
Zimmer Biomet
NCT05787821
Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease
University of Colorado, Denver
NCT03297775
Rheumatology Diet Study
University of Central Florida
NCT06339957
Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease
University of Colorado, Denver
NCT06397677
Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response
University of Nebraska
NCT03414502
An Adaptive Phase 2a/2b Study of LY3871801 in Adult Participants With Rheumatoid Arthritis
Eli Lilly and Company
NCT05848258
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
AstraZeneca
NCT07276581
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer
National Cancer Institute (NCI)
NCT03816345
A Study of SPY072 in Rheumatic Disease
Spyre Therapeutics
NCT07148414
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
NCT05869955
Creating Health Course Study for People With Rheumatological Conditions
Terry L. Wahls
NCT07180537
Dynamic Treatment Regiments for Glucocorticoid Tapering
VA Office of Research and Development
NCT06072768
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
AbbVie
NCT06972446
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
Hoffmann-La Roche
NCT07137598
Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes
University of Florida
NCT05277025
Effect of Anti-inflammatory Diet in Rheumatoid Arthritis
University of California, San Diego
NCT04748809
EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))
DePuy Orthopaedics
NCT06631638
Early Rheumatoid Arthritis Lung Disease Study
University of Nebraska
NCT03192267
Study of GS-0151 in Participants With Rheumatoid Arthritis
Gilead Sciences
NCT06902519
MAD Study of IA-14069
ILAb Co.
NCT05533372
Analysis of T and B Cell Repertoire Changes in Response to Orencia® (Abatacept) in Rheumatoid Arthritis
Hospital for Special Surgery, New York
NCT05782335
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
AstraZeneca
NCT06916806
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
AstraZeneca
NCT07201558
Imaging of Lymphatic Vessels in People with Rheumatoid Arthritis (RA)
University of Rochester
NCT05197530
NSAIDs vs. Coxibs in the Presence of Aspirin
Inova Health Care Services
NCT03699293
Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases.
IRIS Research and Development
NCT06581562
ConsideRAte Study - Splenic Stimulation for RA
Galvani Bioelectronics
NCT05003310
A Study of AZD0120 in Autoimmune Diseases
AstraZeneca
NCT07295847
Improving Hypertension Control in Rheumatoid Arthritis
Duke University
NCT05760898
Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis
Sonoma Biotherapeutics
NCT06201416
Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis
Duke University
NCT06841562
Frequency and Complications of Major Orthopedic Procedures in Medicare Beneficiaries
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT02281747
A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
AbbVie
NCT02629159
Brigham and Women's Rheumatoid Arthritis Sequential Study
Brigham and Women's Hospital
NCT01793103
OTIS Cimzia Pregnancy Registry
University of California, San Diego
NCT01797224
Persona Total Knee Arthroplasty Outcomes Study
Zimmer Biomet
NCT02255383
Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis
AbbVie
NCT05814627
A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Rheumatoid Arthritis (RENOIR)
AnaptysBio
NCT06041269
A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
Bristol-Myers Squibb
NCT04909801
Insignia™ Hip Stem Outcomes Study
Stryker Orthopaedics
NCT05144191
Cemented vs Cementless Persona Keel RCT
Zimmer Biomet
NCT05630053
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
Smith & Nephew
NCT05197036
A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
Zimmer Biomet
NCT01542580
Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis
SetPoint Medical Corporation
NCT04539964
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 33 |
| Phase 2 | 44 |
| Phase 3 | 25 |
| Phase 4 | 7 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Rheumatoid Arthritis Trial Landscape
199 indexed Rheumatoid Arthritis studies · 37 recruiting (19%).
Phase mix: 32 late (III/IV) vs 77 early (I/II).
Top sponsor: Zimmer Biomet (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Rheumatoid Arthritis?
PlainTrial tracks 199 US clinical trials for Rheumatoid Arthritis, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Rheumatoid Arthritis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.