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ClinicalTrials.gov 37 recruiting now official registry

Rheumatoid Arthritis clinical trials

Every US clinical trial registered for Rheumatoid Arthritis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

199 US clinical trials · 37 currently recruiting

The research picture

Rheumatoid Arthritis has 199 registered US clinical trials, 37 of them open to new participants right now — about 19% of the total.

37
recruiting participants now
19%
of trials open to enrollment
32
in Phase 3–4 (later-stage)
13
top sponsor: Zimmer Biomet

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 20,000 participants

Exactech Shoulder Post Market Clinical Follow-up Study

Exactech

NCT05603728

RECRUITING 1,410 participants

Prospective, Multi-Center, Observational, Whole Blood Specimen Collection Study in Participants with Rheumatoid Arthritis with Inadequate Response or Intolerance to a DMARD Starting a New BDMARD or TsDMARD Treatment +/- CsDMARD

Aqtual

NCT05936970

RECRUITING 1,100 participants

PREDICT Therapy Selection for JAK, T-cell, or IL-6 Inhibitor Therapies Using a Molecular Signature Response Classifier (PREDICT)

Scipher Medicine

NCT06390709

RECRUITING 1,000 participants

Maternal Autoimmune Disease Research Alliance (MADRA) Registry

Duke University

NCT03276923

RECRUITING Phase 3 924 participants

RA-PRO PRAGMATIC TRIAL

University of Alabama at Birmingham

NCT04692493

RECRUITING NA 800 participants

Physica System Total Knee Replacement Registry Study

Limacorporate S.p.a

NCT03048201

RECRUITING 760 participants

Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)

Zimmer Biomet

NCT05787821

RECRUITING 750 participants

Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease

University of Colorado, Denver

NCT03297775

RECRUITING 500 participants

Rheumatology Diet Study

University of Central Florida

NCT06339957

RECRUITING 450 participants

Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease

University of Colorado, Denver

NCT06397677

RECRUITING Phase 3 400 participants

Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response

University of Nebraska

NCT03414502

RECRUITING Phase 2 380 participants

An Adaptive Phase 2a/2b Study of LY3871801 in Adult Participants With Rheumatoid Arthritis

Eli Lilly and Company

NCT05848258

RECRUITING Phase 2 320 participants

A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis

AstraZeneca

NCT07276581

RECRUITING Phase 1 300 participants

Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer

National Cancer Institute (NCI)

NCT03816345

RECRUITING Phase 2 285 participants

A Study of SPY072 in Rheumatic Disease

Spyre Therapeutics

NCT07148414

RECRUITING Phase 1 270 participants

A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

NCT05869955

RECRUITING NA 200 participants

Creating Health Course Study for People With Rheumatological Conditions

Terry L. Wahls

NCT07180537

RECRUITING Phase 2 200 participants

Dynamic Treatment Regiments for Glucocorticoid Tapering

VA Office of Research and Development

NCT06072768

RECRUITING Phase 2 180 participants

A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis

AbbVie

NCT06972446

RECRUITING Phase 2 160 participants

A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)

Hoffmann-La Roche

NCT07137598

RECRUITING 150 participants

Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

University of Florida

NCT05277025

RECRUITING NA 124 participants

Effect of Anti-inflammatory Diet in Rheumatoid Arthritis

University of California, San Diego

NCT04748809

RECRUITING NA 118 participants

EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))

DePuy Orthopaedics

NCT06631638

RECRUITING 100 participants

Early Rheumatoid Arthritis Lung Disease Study

University of Nebraska

NCT03192267

RECRUITING Phase 1 75 participants

Study of GS-0151 in Participants With Rheumatoid Arthritis

Gilead Sciences

NCT06902519

RECRUITING Phase 1 75 participants

MAD Study of IA-14069

ILAb Co.

NCT05533372

RECRUITING 72 participants

Analysis of T and B Cell Repertoire Changes in Response to Orencia® (Abatacept) in Rheumatoid Arthritis

Hospital for Special Surgery, New York

NCT05782335

RECRUITING Phase 1 72 participants

A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.

AstraZeneca

NCT06916806

RECRUITING Phase 1 48 participants

Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants

AstraZeneca

NCT07201558

RECRUITING Phase 1 40 participants

Imaging of Lymphatic Vessels in People with Rheumatoid Arthritis (RA)

University of Rochester

NCT05197530

RECRUITING Phase 4 30 participants

NSAIDs vs. Coxibs in the Presence of Aspirin

Inova Health Care Services

NCT03699293

RECRUITING Phase 1 30 participants

Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases.

IRIS Research and Development

NCT06581562

RECRUITING NA 28 participants

ConsideRAte Study - Splenic Stimulation for RA

Galvani Bioelectronics

NCT05003310

RECRUITING Phase 1 27 participants

A Study of AZD0120 in Autoimmune Diseases

AstraZeneca

NCT07295847

RECRUITING NA 25 participants

Improving Hypertension Control in Rheumatoid Arthritis

Duke University

NCT05760898

RECRUITING Phase 1 24 participants

Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis

Sonoma Biotherapeutics

NCT06201416

RECRUITING NA 15 participants

Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis

Duke University

NCT06841562

ACTIVE NOT RECRUITING 521,292 participants

Frequency and Complications of Major Orthopedic Procedures in Medicare Beneficiaries

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NCT02281747

ACTIVE NOT RECRUITING Phase 3 1,629 participants

A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate

AbbVie

NCT02629159

ACTIVE NOT RECRUITING 1,598 participants

Brigham and Women's Rheumatoid Arthritis Sequential Study

Brigham and Women's Hospital

NCT01793103

ACTIVE NOT RECRUITING 925 participants

OTIS Cimzia Pregnancy Registry

University of California, San Diego

NCT01797224

ACTIVE NOT RECRUITING NA 737 participants

Persona Total Knee Arthroplasty Outcomes Study

Zimmer Biomet

NCT02255383

ACTIVE NOT RECRUITING Phase 3 487 participants

Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis

AbbVie

NCT05814627

ACTIVE NOT RECRUITING Phase 2 420 participants

A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Rheumatoid Arthritis (RENOIR)

AnaptysBio

NCT06041269

ACTIVE NOT RECRUITING Phase 3 338 participants

A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate

Bristol-Myers Squibb

NCT04909801

ACTIVE NOT RECRUITING NA 313 participants

Insignia™ Hip Stem Outcomes Study

Stryker Orthopaedics

NCT05144191

ACTIVE NOT RECRUITING NA 300 participants

Cemented vs Cementless Persona Keel RCT

Zimmer Biomet

NCT05630053

ACTIVE NOT RECRUITING 299 participants

A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis

Smith & Nephew

NCT05197036

ACTIVE NOT RECRUITING 255 participants

A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee

Zimmer Biomet

NCT01542580

ACTIVE NOT RECRUITING Phase 3 243 participants

Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis

SetPoint Medical Corporation

NCT04539964

ACTIVE NOT RECRUITING NA 240 participants

Persona Ti-Nidium Post-Market Clinical Follow-up

Zimmer Biomet

NCT04817969

ACTIVE NOT RECRUITING 200 participants

Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System

Zimmer Biomet

NCT01480440

ACTIVE NOT RECRUITING 165 participants

Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study

Zimmer Biomet

NCT01307384

ACTIVE NOT RECRUITING 160 participants

Database Retrieval for the Comprehensive Shoulder

Zimmer Biomet

NCT03409718

ACTIVE NOT RECRUITING Phase 2 155 participants

Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease

Novartis Pharmaceuticals

NCT06293365

ACTIVE NOT RECRUITING Phase 2 154 participants

The Immunogenicity and Safety of Zostavax® and Shingrix® in Rheumatoid Arthritis Patients Using Abatacept

Kevin Winthrop

NCT03604406

ACTIVE NOT RECRUITING NA 135 participants

Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating System

Zimmer Biomet

NCT03626038

ACTIVE NOT RECRUITING NA 120 participants

Zimmer Trabecular Metal Total Ankle PMCF

Zimmer Biomet

NCT02038140

ACTIVE NOT RECRUITING Phase 2 120 participants

A Study to Evaluate the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat Rheumatoid Arthritis

Immunovant Sciences

NCT06754462

ACTIVE NOT RECRUITING NA 101 participants

Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity

Brigham and Women's Hospital

NCT05715463

ACTIVE NOT RECRUITING 100 participants

Utilizing MRI for Earlier Diagnosis of Rheumatoid Arthritis

Mayo Clinic

NCT03841279

ACTIVE NOT RECRUITING Phase 1 55 participants

Study of GS-0272 in Participants With Rheumatoid Arthritis

Gilead Sciences

NCT06031415

ACTIVE NOT RECRUITING Phase 2 35 participants

A Study of LY3541860 in Adult Participants With Moderately to Severely Active Rheumatoid Arthritis

Eli Lilly and Company

NCT06859294

ACTIVE NOT RECRUITING 25 participants

Discovering the Antecedents of Rheumatoid Arthritis Flare

Rockefeller University

NCT02051114

ACTIVE NOT RECRUITING NA 14 participants

Long Term Extension of Safety and Efficacy of Vagus Nerve Stimulator in Patients With Rheumatoid Arthritis (RA)

SetPoint Medical Corporation

NCT04862117

ACTIVE NOT RECRUITING NA 12 participants

A Clinical Study to Assess the Efficacy of Cannabigerol in Patients with Active Rheumatoid Arthritis.

Raphael Pharma

NCT06513507

COMPLETED 133,553 participants

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Methotrexate vs Hydroxychloroquine

Brigham and Women's Hospital

NCT04691505

COMPLETED 105,711 participants

Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)- Cardiovascular Endpoints

Brigham and Women's Hospital

NCT04772248

COMPLETED 30,432 participants

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tocilizumab vs Abatacept

Brigham and Women's Hospital

NCT04529863

COMPLETED 29,464 participants

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tofacitinib vs Abatacept

Brigham and Women's Hospital

NCT04529876

COMPLETED 21,340 participants

A Study to Understand How Effective is Tofacitinib When Compared to Other Advanced Treatments in Patients With Rheumatoid Arthritis

Pfizer

NCT06418529

COMPLETED Phase 4 4,659 participants

Improving Bone Health Among Rheumatoid Arthritis (RA) Patients on Chronic Glucocorticoids

University of Alabama at Birmingham

NCT01378689

COMPLETED Phase 3 3,000 participants

Study of Human Anti-TNF Monoclonal Antibody D2E7 in Subjects With Active Rheumatoid Arthritis

Abbott

NCT00049751

COMPLETED 2,795 participants

Effectiveness Registry to Study Therapies for Arthritis and Inflammatory Conditions: The Corrona CERTAIN Sub-study

CorEvitas

NCT01625650

COMPLETED Phase 3 2,106 participants

Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis

R-Pharm International

NCT03120949

COMPLETED Phase 3 1,648 participants

Certolizumab Pegol for the Treatment of Patients With Active Rheumatoid Arthritis

UCB Pharma

NCT00717236

COMPLETED NA 1,593 participants

Clinical Study Evaluating an Acetabular Cup System After Total Hip Replacement

DePuy Orthopaedics

NCT00306930

COMPLETED Phase 4 1,317 participants

A Study of Baricitinib in Participants With Rheumatoid Arthritis

Eli Lilly and Company

NCT04086745

COMPLETED Phase 3 1,286 participants

Study of Abatacept (BMS-188667) in Subjects With Active Rheumatoid Arthritis on Background Non-biologic DMARDS (Disease Modifying Antirheumatic Drugs) Who Have an Inadequate Response to Anti-TNF Therapy

Bristol-Myers Squibb

NCT00124982

COMPLETED Phase 3 1,262 participants

A Study to Compare Subcutaneous Versus Intravenous Administration of RoActemra/Actemra (Tocilizumab) in Participants With Moderate to Severe Active Rheumatoid Arthritis

Hoffmann-La Roche

NCT01194414

COMPLETED 1,062 participants

Genetic Registry for Rheumatoid Arthritis

Northwell Health

NCT00069472

COMPLETED 1,056 participants

Study of Families With Twins or Siblings Discordant for Rheumatic Disorders

National Institute of Environmental Health Sciences (NIEHS)

NCT00055055

COMPLETED NA 900 participants

Development and Evaluation of A Mailed Arthritis Self-Management Program

University of North Carolina

NCT00448474

COMPLETED Phase 3 846 participants

Long Term Open Label Continuation Study

Abbott

NCT00195650

COMPLETED Phase 2 739 participants

Long-term Follow-up Study of GLPG0634 in Active Rheumatoid Arthritis Participants

Galapagos

NCT02065700

COMPLETED Phase 3 656 participants

A Study of RoActemra/Actemra (Tocilizumab) Given Subcutaneously in Combination With Traditional DMARDs in Patients With Moderate to Severe Active Rheumatoid Arthritis

Hoffmann-La Roche

NCT01232569

COMPLETED Phase 3 637 participants

Efficacy at 24 Weeks and Safety, Tolerability and Long Term Efficacy up to 2 Years of Secukinumab (AIN457) in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Anti-TNFα Agents

Novartis Pharmaceuticals

NCT01377012

COMPLETED 617 participants

Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis

University of Nebraska

NCT01156155

COMPLETED 598 participants

Risk of Coccidioidomycosis in Patients Receiving Anti-TNF and Other Biologic Agents for an Inflammatory Arthritis

University of Arizona

NCT00796809

COMPLETED Phase 3 588 participants

A Study in Participants With Moderate to Severe Rheumatoid Arthritis

Eli Lilly and Company

NCT01711359

COMPLETED 571 participants

Assess Structural Damage in Rheumatoid Arthritis Using Biomarkers and Radiography

CARE ARTHRITIS

NCT01476956

COMPLETED Phase 3 556 participants

A Study of Tocilizumab and Methotrexate Treatment Strategies (Adding Tocilizumab to Methotrexate Versus Switching to Tocilizumab) in Patients With Active Rheumatoid Arthritis With Inadequate Response to Prior Methotrexate Treatment

Hoffmann-La Roche

NCT00810199

COMPLETED Phase 2 524 participants

Abatacept With Methotrexate- Phase IIB

Bristol-Myers Squibb

NCT00162266

COMPLETED 479 participants

Comparative Analysis of Outcomes Among Patients Initiating Xeljanz in Combination With Oral MTX Who Withdraw MTX Versus Continue MTX

Pfizer

NCT03975790

COMPLETED 400 participants

Identification of Genes Associated With Lung Disease in Patients With Rheumatoid Arthritis

National Heart, Lung, and Blood Institute (NHLBI)

NCT00001885

COMPLETED Phase 3 371 participants

Study of Etanercept Monotherapy vs Methotrexate Monotherapy for Maintenance of Rheumatoid Arthritis Remission

Amgen

NCT02373813

COMPLETED Phase 3 369 participants

Efficacy and Safety of Sarilumab and Adalimumab Monotherapy in Patients With Rheumatoid Arthritis (SARIL-RA-MONARCH)

Sanofi

NCT02332590

COMPLETED Phase 1 356 participants

Study to Characterize the Pharmacokinetics of a Single Dose of SC Abatacept 125 mg Using the BD Autoinjector or the Prefilled Syringe

Bristol-Myers Squibb

NCT01890473

COMPLETED NA 353 participants

Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy

US Department of Veterans Affairs

NCT00405275

COMPLETED Phase 4 351 participants

A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis

Hoffmann-La Roche

NCT01382940

Phase Distribution

PhaseTrial count
Phase 1 33
Phase 2 44
Phase 3 25
Phase 4 7

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Rheumatoid Arthritis Trial Landscape

ClinicalTrials.gov lists 199 US studies indexed under Rheumatoid Arthritis, and 37 of those are currently open to recruitment — roughly 19% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Rheumatoid Arthritis shows 32 late-stage studies (Phase 3 and Phase 4 combined) alongside 77 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Rheumatoid Arthritis is led by Zimmer Biomet with 13 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Rheumatoid Arthritis?

PlainTrial tracks 199 US clinical trials for Rheumatoid Arthritis, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Rheumatoid Arthritis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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