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Rheumatoid Arthritis clinical trials
Every US clinical trial registered for Rheumatoid Arthritis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
199 US clinical trials · 37 currently recruiting
The research picture
Rheumatoid Arthritis has 199 registered US clinical trials, 37 of them open to new participants right now — about 19% of the total.
- 37
- recruiting participants now
- 19%
- of trials open to enrollment
- 32
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Zimmer Biomet
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Exactech Shoulder Post Market Clinical Follow-up Study
Exactech
NCT05603728
Prospective, Multi-Center, Observational, Whole Blood Specimen Collection Study in Participants with Rheumatoid Arthritis with Inadequate Response or Intolerance to a DMARD Starting a New BDMARD or TsDMARD Treatment +/- CsDMARD
Aqtual
NCT05936970
PREDICT Therapy Selection for JAK, T-cell, or IL-6 Inhibitor Therapies Using a Molecular Signature Response Classifier (PREDICT)
Scipher Medicine
NCT06390709
Maternal Autoimmune Disease Research Alliance (MADRA) Registry
Duke University
NCT03276923
RA-PRO PRAGMATIC TRIAL
University of Alabama at Birmingham
NCT04692493
Physica System Total Knee Replacement Registry Study
Limacorporate S.p.a
NCT03048201
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
Zimmer Biomet
NCT05787821
Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease
University of Colorado, Denver
NCT03297775
Rheumatology Diet Study
University of Central Florida
NCT06339957
Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease
University of Colorado, Denver
NCT06397677
Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response
University of Nebraska
NCT03414502
An Adaptive Phase 2a/2b Study of LY3871801 in Adult Participants With Rheumatoid Arthritis
Eli Lilly and Company
NCT05848258
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
AstraZeneca
NCT07276581
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer
National Cancer Institute (NCI)
NCT03816345
A Study of SPY072 in Rheumatic Disease
Spyre Therapeutics
NCT07148414
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
NCT05869955
Creating Health Course Study for People With Rheumatological Conditions
Terry L. Wahls
NCT07180537
Dynamic Treatment Regiments for Glucocorticoid Tapering
VA Office of Research and Development
NCT06072768
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
AbbVie
NCT06972446
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
Hoffmann-La Roche
NCT07137598
Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes
University of Florida
NCT05277025
Effect of Anti-inflammatory Diet in Rheumatoid Arthritis
University of California, San Diego
NCT04748809
EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))
DePuy Orthopaedics
NCT06631638
Early Rheumatoid Arthritis Lung Disease Study
University of Nebraska
NCT03192267
Study of GS-0151 in Participants With Rheumatoid Arthritis
Gilead Sciences
NCT06902519
MAD Study of IA-14069
ILAb Co.
NCT05533372
Analysis of T and B Cell Repertoire Changes in Response to Orencia® (Abatacept) in Rheumatoid Arthritis
Hospital for Special Surgery, New York
NCT05782335
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
AstraZeneca
NCT06916806
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
AstraZeneca
NCT07201558
Imaging of Lymphatic Vessels in People with Rheumatoid Arthritis (RA)
University of Rochester
NCT05197530
NSAIDs vs. Coxibs in the Presence of Aspirin
Inova Health Care Services
NCT03699293
Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases.
IRIS Research and Development
NCT06581562
ConsideRAte Study - Splenic Stimulation for RA
Galvani Bioelectronics
NCT05003310
A Study of AZD0120 in Autoimmune Diseases
AstraZeneca
NCT07295847
Improving Hypertension Control in Rheumatoid Arthritis
Duke University
NCT05760898
Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis
Sonoma Biotherapeutics
NCT06201416
Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis
Duke University
NCT06841562
Frequency and Complications of Major Orthopedic Procedures in Medicare Beneficiaries
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT02281747
A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
AbbVie
NCT02629159
Brigham and Women's Rheumatoid Arthritis Sequential Study
Brigham and Women's Hospital
NCT01793103
OTIS Cimzia Pregnancy Registry
University of California, San Diego
NCT01797224
Persona Total Knee Arthroplasty Outcomes Study
Zimmer Biomet
NCT02255383
Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis
AbbVie
NCT05814627
A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Rheumatoid Arthritis (RENOIR)
AnaptysBio
NCT06041269
A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
Bristol-Myers Squibb
NCT04909801
Insignia™ Hip Stem Outcomes Study
Stryker Orthopaedics
NCT05144191
Cemented vs Cementless Persona Keel RCT
Zimmer Biomet
NCT05630053
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
Smith & Nephew
NCT05197036
A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
Zimmer Biomet
NCT01542580
Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis
SetPoint Medical Corporation
NCT04539964
Persona Ti-Nidium Post-Market Clinical Follow-up
Zimmer Biomet
NCT04817969
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
Zimmer Biomet
NCT01480440
Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study
Zimmer Biomet
NCT01307384
Database Retrieval for the Comprehensive Shoulder
Zimmer Biomet
NCT03409718
Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease
Novartis Pharmaceuticals
NCT06293365
The Immunogenicity and Safety of Zostavax® and Shingrix® in Rheumatoid Arthritis Patients Using Abatacept
Kevin Winthrop
NCT03604406
Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating System
Zimmer Biomet
NCT03626038
Zimmer Trabecular Metal Total Ankle PMCF
Zimmer Biomet
NCT02038140
A Study to Evaluate the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat Rheumatoid Arthritis
Immunovant Sciences
NCT06754462
Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity
Brigham and Women's Hospital
NCT05715463
Utilizing MRI for Earlier Diagnosis of Rheumatoid Arthritis
Mayo Clinic
NCT03841279
Study of GS-0272 in Participants With Rheumatoid Arthritis
Gilead Sciences
NCT06031415
A Study of LY3541860 in Adult Participants With Moderately to Severely Active Rheumatoid Arthritis
Eli Lilly and Company
NCT06859294
Discovering the Antecedents of Rheumatoid Arthritis Flare
Rockefeller University
NCT02051114
Long Term Extension of Safety and Efficacy of Vagus Nerve Stimulator in Patients With Rheumatoid Arthritis (RA)
SetPoint Medical Corporation
NCT04862117
A Clinical Study to Assess the Efficacy of Cannabigerol in Patients with Active Rheumatoid Arthritis.
Raphael Pharma
NCT06513507
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Methotrexate vs Hydroxychloroquine
Brigham and Women's Hospital
NCT04691505
Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)- Cardiovascular Endpoints
Brigham and Women's Hospital
NCT04772248
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tocilizumab vs Abatacept
Brigham and Women's Hospital
NCT04529863
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tofacitinib vs Abatacept
Brigham and Women's Hospital
NCT04529876
A Study to Understand How Effective is Tofacitinib When Compared to Other Advanced Treatments in Patients With Rheumatoid Arthritis
Pfizer
NCT06418529
Improving Bone Health Among Rheumatoid Arthritis (RA) Patients on Chronic Glucocorticoids
University of Alabama at Birmingham
NCT01378689
Study of Human Anti-TNF Monoclonal Antibody D2E7 in Subjects With Active Rheumatoid Arthritis
Abbott
NCT00049751
Effectiveness Registry to Study Therapies for Arthritis and Inflammatory Conditions: The Corrona CERTAIN Sub-study
CorEvitas
NCT01625650
Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis
R-Pharm International
NCT03120949
Certolizumab Pegol for the Treatment of Patients With Active Rheumatoid Arthritis
UCB Pharma
NCT00717236
Clinical Study Evaluating an Acetabular Cup System After Total Hip Replacement
DePuy Orthopaedics
NCT00306930
A Study of Baricitinib in Participants With Rheumatoid Arthritis
Eli Lilly and Company
NCT04086745
Study of Abatacept (BMS-188667) in Subjects With Active Rheumatoid Arthritis on Background Non-biologic DMARDS (Disease Modifying Antirheumatic Drugs) Who Have an Inadequate Response to Anti-TNF Therapy
Bristol-Myers Squibb
NCT00124982
A Study to Compare Subcutaneous Versus Intravenous Administration of RoActemra/Actemra (Tocilizumab) in Participants With Moderate to Severe Active Rheumatoid Arthritis
Hoffmann-La Roche
NCT01194414
Genetic Registry for Rheumatoid Arthritis
Northwell Health
NCT00069472
Study of Families With Twins or Siblings Discordant for Rheumatic Disorders
National Institute of Environmental Health Sciences (NIEHS)
NCT00055055
Development and Evaluation of A Mailed Arthritis Self-Management Program
University of North Carolina
NCT00448474
Long Term Open Label Continuation Study
Abbott
NCT00195650
Long-term Follow-up Study of GLPG0634 in Active Rheumatoid Arthritis Participants
Galapagos
NCT02065700
A Study of RoActemra/Actemra (Tocilizumab) Given Subcutaneously in Combination With Traditional DMARDs in Patients With Moderate to Severe Active Rheumatoid Arthritis
Hoffmann-La Roche
NCT01232569
Efficacy at 24 Weeks and Safety, Tolerability and Long Term Efficacy up to 2 Years of Secukinumab (AIN457) in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Anti-TNFα Agents
Novartis Pharmaceuticals
NCT01377012
Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis
University of Nebraska
NCT01156155
Risk of Coccidioidomycosis in Patients Receiving Anti-TNF and Other Biologic Agents for an Inflammatory Arthritis
University of Arizona
NCT00796809
A Study in Participants With Moderate to Severe Rheumatoid Arthritis
Eli Lilly and Company
NCT01711359
Assess Structural Damage in Rheumatoid Arthritis Using Biomarkers and Radiography
CARE ARTHRITIS
NCT01476956
A Study of Tocilizumab and Methotrexate Treatment Strategies (Adding Tocilizumab to Methotrexate Versus Switching to Tocilizumab) in Patients With Active Rheumatoid Arthritis With Inadequate Response to Prior Methotrexate Treatment
Hoffmann-La Roche
NCT00810199
Abatacept With Methotrexate- Phase IIB
Bristol-Myers Squibb
NCT00162266
Comparative Analysis of Outcomes Among Patients Initiating Xeljanz in Combination With Oral MTX Who Withdraw MTX Versus Continue MTX
Pfizer
NCT03975790
Identification of Genes Associated With Lung Disease in Patients With Rheumatoid Arthritis
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001885
Study of Etanercept Monotherapy vs Methotrexate Monotherapy for Maintenance of Rheumatoid Arthritis Remission
Amgen
NCT02373813
Efficacy and Safety of Sarilumab and Adalimumab Monotherapy in Patients With Rheumatoid Arthritis (SARIL-RA-MONARCH)
Sanofi
NCT02332590
Study to Characterize the Pharmacokinetics of a Single Dose of SC Abatacept 125 mg Using the BD Autoinjector or the Prefilled Syringe
Bristol-Myers Squibb
NCT01890473
Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy
US Department of Veterans Affairs
NCT00405275
A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis
Hoffmann-La Roche
NCT01382940
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 33 |
| Phase 2 | 44 |
| Phase 3 | 25 |
| Phase 4 | 7 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Rheumatoid Arthritis Trial Landscape
ClinicalTrials.gov lists 199 US studies indexed under Rheumatoid Arthritis, and 37 of those are currently open to recruitment — roughly 19% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Rheumatoid Arthritis shows 32 late-stage studies (Phase 3 and Phase 4 combined) alongside 77 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Rheumatoid Arthritis is led by Zimmer Biomet with 13 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Rheumatoid Arthritis?
PlainTrial tracks 199 US clinical trials for Rheumatoid Arthritis, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Rheumatoid Arthritis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.