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NCT07132177 · ClinicalTrials.gov registry record · Phase 2
Targeted Naltrexone to Support Individuals Participating in Dry January
A Phase 2 study of Alcohol Misuse, sponsored by Brigham and Women's Hospital.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT07132177: Recruiting Phase 2 study of Alcohol Misuse, sponsored by Brigham and Women's Hospital.
NCT07132177 is a Phase 2 study of Alcohol Misuse that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 20 participants, below the 1,622-participant average among 8 other Alcohol Misuse trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07132177, a Phase 2 study of Alcohol Misuse, is actively recruiting participants, sponsored by Brigham and Women's Hospital.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This pilot open-label study will assess the feasibility, acceptability, and preliminary efficacy of targeted (as-needed) oral naltrexone in individuals participating in "Dry January," a month-long voluntary abstinence or reduction in alcohol use. Participants who do not meet criteria for alcohol use disorder (AUD) but are interested in reducing or abstaining from alcohol will receive a 31-day supply of 50mg oral naltrexone to take either prior to anticipated drinking or daily as a precaution. The study will evaluate recruitment, retention, adherence, and safety, as well as changes in alcohol use patterns, craving, mood, liver function, and quality of life. A qualitative interview at follow-up will explore participants' experiences using naltrexone during Dry January. Results will inform future randomized trials testing low-intensity, scalable interventions for non-treatment-seeking individuals seeking to reduce alcohol consumption.
Primary Outcome
Recruitment: Proportion of those screened who successfully enroll in the trial. Greater than 75% enrollment will be considered excellent, and greater than 50% enrollment will be considered good.
Conditions Studied
Interventions
- DRUG Naltrexone (oral tablets)
Study Locations (1)
Massachusetts
- Brigham and Women's hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2025-11-03 |
| Est. Completion | 2026-05-01 |
| Phase | Phase 2 |
What NCT07132177 shows while recruiting
NCT07132177 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,622-participant average among 8 other Alcohol Misuse trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Alcohol Misuse appearing as the primary indexed condition, and to 1 intervention - of which Naltrexone (oral tablets) is the first listed.
NCT07132177 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07132177 about?
NCT07132177 is a clinical study titled "Targeted Naltrexone to Support Individuals Participating in Dry January". This pilot open-label study will assess the feasibility, acceptability, and preliminary efficacy of targeted (as-needed) oral naltrexone in individuals participating in "Dry January," a month-long voluntary abstinence or reduction in alcohol use. Participants who do not meet criteria for alcohol use...
What is the current status of trial NCT07132177?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2025-11-03. Estimated completion is 2026-05-01.
What conditions does trial NCT07132177 study?
This clinical trial studies the following conditions: Alcohol Misuse.
What interventions are being tested in trial NCT07132177?
The interventions under investigation include: Naltrexone (oral tablets) (DRUG).
Who is sponsoring clinical trial NCT07132177?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07132177 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Misuse
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07132177's enrollment target sits among peer trials
20 9th of 8 the lowest of 8 other Alcohol Misuse trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Misuse trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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