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NCT07245641 · ClinicalTrials.gov registry record · NA
Targeted Accelerated TMS for Post-Traumatic Stress Disorder
A NA study of Post Traumatic Stress Disorder (PTSD), sponsored by Brigham and Women's Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT07245641 is a NA study of Post Traumatic Stress Disorder (PTSD) that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 40 participants, below the 113-participant average among 13 other Post Traumatic Stress Disorder (PTSD) trials with a reported enrollment target (65% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07245641, a NA study of Post Traumatic Stress Disorder (PTSD), is actively recruiting participants, sponsored by Brigham and Women's Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Post-traumatic stress disorder (PTSD) is a highly prevalent and debilitating condition among veterans and active-duty military personnel, with rates as high as 30% in certain combat-exposed populations. Conventional treatments such as prolonged exposure therapy and pharmacotherapy have limited efficacy and high dropout rates, highlighting the need for novel, rapidly effective interventions. Transcranial magnetic stimulation (TMS) has been well established for treatment-resistant depression (TRD). Traditional TMS, which involves 6 to 7 weeks of daily, weekday scalp-targeted treatment, shows open-label response and remission rates of 58.1% and 30%, respectively. However, such protocols may be impractical for military personnel with limited medical leave. A new form of accelerated TMS (aTMS) that involves 10 imaging-guided treatments per day for 5 consecutive days has demonstrated substantial antidepressant benefits within days and response rates of 69% at 1-month follow-up. This protocol has not been tested for PTSD, in part because there was no causally informed brain circuit target. In this study, the investigators will test aTMS for PTSD using a novel PTSD circuit that the investigators have derived.
Conditions Studied
Interventions
- PROCEDURE Transcranial Magnetic Stimulation
Study Locations (1)
Massachusetts
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-12-15 |
| Est. Completion | 2028-01 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07245641
The ClinicalTrials.gov registry entry for NCT07245641 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 113-participant average among 13 other Post Traumatic Stress Disorder (PTSD) trials with a reported enrollment target (65% lower). The listed sponsor is Brigham and Women's Hospital, which has 937 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Post Traumatic Stress Disorder (PTSD) appearing as the primary indexed condition, and to 1 intervention - of which Transcranial Magnetic Stimulation is the first listed.
NCT07245641 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07245641 about?
NCT07245641 is a clinical study titled "Targeted Accelerated TMS for Post-Traumatic Stress Disorder". Post-traumatic stress disorder (PTSD) is a highly prevalent and debilitating condition among veterans and active-duty military personnel, with rates as high as 30% in certain combat-exposed populations. Conventional treatments such as prolonged exposure therapy and pharmacotherapy have limited effic...
What is the current status of trial NCT07245641?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2025-12-15. Estimated completion is 2028-01.
What conditions does trial NCT07245641 study?
This clinical trial studies the following conditions: Post Traumatic Stress Disorder (PTSD).
What interventions are being tested in trial NCT07245641?
The interventions under investigation include: Transcranial Magnetic Stimulation (PROCEDURE).
Who is sponsoring clinical trial NCT07245641?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07245641 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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