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NCT07245641 · ClinicalTrials.gov registry record · NA
Targeted Accelerated TMS for Post-Traumatic Stress Disorder
A NA study of Posttraumatic Stress Disorder (PTSD), sponsored by Brigham and Women's Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT07245641: Recruiting NA study of Posttraumatic Stress Disorder (PTSD), sponsored by Brigham and Women's Hospital.
NCT07245641 is a NA study of Posttraumatic Stress Disorder (PTSD) that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 40 participants, below the 110-participant average among 31 other Posttraumatic Stress Disorder (PTSD) trials with a reported enrollment target (64% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07245641, a NA study of Posttraumatic Stress Disorder (PTSD), is actively recruiting participants, sponsored by Brigham and Women's Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Post-traumatic stress disorder (PTSD) is a highly prevalent and debilitating condition among veterans and active-duty military personnel, with rates as high as 30% in certain combat-exposed populations. Conventional treatments such as prolonged exposure therapy and pharmacotherapy have limited efficacy and high dropout rates, highlighting the need for novel, rapidly effective interventions. Transcranial magnetic stimulation (TMS) has been well established for treatment-resistant depression (TRD). Traditional TMS, which involves 6 to 7 weeks of daily, weekday scalp-targeted treatment, shows open-label response and remission rates of 58.1% and 30%, respectively. However, such protocols may be impractical for military personnel with limited medical leave. A new form of accelerated TMS (aTMS) that involves 10 imaging-guided treatments per day for 5 consecutive days has demonstrated substantial antidepressant benefits within days and response rates of 69% at 1-month follow-up. This protocol has not been tested for PTSD, in part because there was no causally informed brain circuit target. In this study, the investigators will test aTMS for PTSD using a novel PTSD circuit that the investigators have derived.
Primary Outcome
20 item PTSD scale, scored 0-80. Higher scores indicate worse symptoms. Investigators will use a repeated measures mixed model to examine the effect of treatment on PCL-5 scores over time as well as a group x time interaction not controlling for depression. Hypothesis: There will be a significant difference in PCL-5 score magnitude of change one month after treatment relative to baseline in the participants receiving active treatment vs. sham
Conditions Studied
Interventions
- PROCEDURE Transcranial Magnetic Stimulation
Study Locations (1)
Massachusetts
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-12-15 |
| Est. Completion | 2028-01 |
| Phase | NA |
What NCT07245641 shows while recruiting
NCT07245641 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 110-participant average among 31 other Posttraumatic Stress Disorder (PTSD) trials with a reported enrollment target (64% lower).
The record links to 1 condition, with Posttraumatic Stress Disorder (PTSD) appearing as the primary indexed condition, and to 1 intervention - of which Transcranial Magnetic Stimulation is the first listed.
NCT07245641 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07245641 about?
NCT07245641 is a clinical study titled "Targeted Accelerated TMS for Post-Traumatic Stress Disorder". Post-traumatic stress disorder (PTSD) is a highly prevalent and debilitating condition among veterans and active-duty military personnel, with rates as high as 30% in certain combat-exposed populations. Conventional treatments such as prolonged exposure therapy and pharmacotherapy have limited effic...
What is the current status of trial NCT07245641?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2025-12-15. Estimated completion is 2028-01.
What conditions does trial NCT07245641 study?
This clinical trial studies the following conditions: Posttraumatic Stress Disorder (PTSD).
What interventions are being tested in trial NCT07245641?
The interventions under investigation include: Transcranial Magnetic Stimulation (PROCEDURE).
Who is sponsoring clinical trial NCT07245641?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07245641 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Posttraumatic Stress Disorder (PTSD)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07245641's enrollment target sits among peer trials
40 25th of 31 higher than 7 of 31 other Posttraumatic Stress Disorder (PTSD) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Posttraumatic Stress Disorder (PTSD) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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