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NCT06727331 · ClinicalTrials.gov registry record · Phase 2
Study of Tirzepatide for Recovery and Alcohol Use Management
A Phase 2 study of Alcohol Use Disorder (AUD), sponsored by Brigham and Women's Hospital.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
- 2
- Study locations
NCT06727331: Recruiting Phase 2 study of Alcohol Use Disorder (AUD), sponsored by Brigham and Women's Hospital.
NCT06727331 is a Phase 2 study of Alcohol Use Disorder (AUD) that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 20 participants, below the 1,823-participant average among 30 other Alcohol Use Disorder (AUD) trials with a reported enrollment target (99% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06727331, a Phase 2 study of Alcohol Use Disorder (AUD), is actively recruiting participants, sponsored by Brigham and Women's Hospital.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
- 2
- Study locations
Study Summary
This is a pilot, 4-week, double-blind, placebo-controlled, randomized trial of individuals with alcohol use disorder (AUD) to receive weekly injections of either tirzepatide (n=10) or matching placebo (n=10). The primary aim is to determine the effects of tirzepatide on cue-reactivity among individuals with AUD. The secondary aim is to assess the safety and preliminary efficacy of tirzepatide for AUD.
Primary Outcome
Cue-induced craving scores at follow-up compared to baseline using a standard cue-reactivity paradigm utilizing visual cues. Cravings will be measured on a scale from 0-10 with 10 meaning extreme cravings.
Conditions Studied
Interventions
- DRUG Tirzepatide
- OTHER Saline Placebo
Study Locations (2)
Massachusetts
- Brigham and Women's Hospital - Boston
- Brigham and Women's Faulkner Hospital - Jamaica Plain
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2025-09-15 |
| Est. Completion | 2026-07 |
| Phase | Phase 2 |
What NCT06727331 shows while recruiting
NCT06727331 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,823-participant average among 30 other Alcohol Use Disorder (AUD) trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Alcohol Use Disorder (AUD) appearing as the primary indexed condition, and to 2 interventions - of which Tirzepatide is the first listed.
NCT06727331 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06727331 about?
NCT06727331 is a clinical study titled "Study of Tirzepatide for Recovery and Alcohol Use Management". This is a pilot, 4-week, double-blind, placebo-controlled, randomized trial of individuals with alcohol use disorder (AUD) to receive weekly injections of either tirzepatide (n=10) or matching placebo (n=10). The primary aim is to determine the effects of tirzepatide on cue-reactivity among individu...
What is the current status of trial NCT06727331?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2025-09-15. Estimated completion is 2026-07.
What conditions does trial NCT06727331 study?
This clinical trial studies the following conditions: Alcohol Use Disorder (AUD).
What interventions are being tested in trial NCT06727331?
The interventions under investigation include: Tirzepatide (DRUG), Saline Placebo (OTHER).
Who is sponsoring clinical trial NCT06727331?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06727331 being conducted?
This trial has 2 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Use Disorder (AUD)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06727331's enrollment target sits among peer trials
20 30th of 30 higher than 1 of 30 other Alcohol Use Disorder (AUD) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Use Disorder (AUD) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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