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NCT06727331 · ClinicalTrials.gov registry record · Phase 2

Study of Tirzepatide for Recovery and Alcohol Use Management

A Phase 2 study of Alcohol Use Disorder (AUD), sponsored by Brigham and Women's Hospital.

Recruiting
Registry status
Phase 2
Development phase
20
Enrollment target
2
Study locations

NCT06727331 is a Phase 2 study of Alcohol Use Disorder (AUD) that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 20 participants, below the 1,823-participant average among 30 other Alcohol Use Disorder (AUD) trials with a reported enrollment target (99% lower). The trial reports 2 study locations across 1 state.

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The verdict

NCT06727331, a Phase 2 study of Alcohol Use Disorder (AUD), is actively recruiting participants, sponsored by Brigham and Women's Hospital.

RECRUITING
Registry status
Phase 2
Development phase
20 participants
Enrollment target
2
Study locations

Study Summary

This is a pilot, 4-week, double-blind, placebo-controlled, randomized trial of individuals with alcohol use disorder (AUD) to receive weekly injections of either tirzepatide (n=10) or matching placebo (n=10). The primary aim is to determine the effects of tirzepatide on cue-reactivity among individuals with AUD. The secondary aim is to assess the safety and preliminary efficacy of tirzepatide for AUD.

Conditions Studied

Alcohol Use Disorder (AUD)

Interventions

  • DRUG Tirzepatide
  • OTHER Saline Placebo

Study Locations (2)

Massachusetts

  • Brigham and Women's Hospital - Boston
  • Brigham and Women's Faulkner Hospital - Jamaica Plain

Trial Details

FieldValue
Enrollment Target 20 participants
Start Date 2025-09-15
Est. Completion 2026-07
Phase Phase 2

Sponsor

Brigham and Women's Hospital

937 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06727331

The ClinicalTrials.gov registry entry for NCT06727331 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,823-participant average among 30 other Alcohol Use Disorder (AUD) trials with a reported enrollment target (99% lower). The listed sponsor is Brigham and Women's Hospital, which has 937 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Alcohol Use Disorder (AUD) appearing as the primary indexed condition, and to 2 interventions - of which Tirzepatide is the first listed.

NCT06727331 reports 2 study locations spanning 1 distinct geographic area - top geographies include Massachusetts.

Frequently Asked Questions

What is clinical trial NCT06727331 about?

NCT06727331 is a clinical study titled "Study of Tirzepatide for Recovery and Alcohol Use Management". This is a pilot, 4-week, double-blind, placebo-controlled, randomized trial of individuals with alcohol use disorder (AUD) to receive weekly injections of either tirzepatide (n=10) or matching placebo (n=10). The primary aim is to determine the effects of tirzepatide on cue-reactivity among individu...

What is the current status of trial NCT06727331?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2025-09-15. Estimated completion is 2026-07.

What conditions does trial NCT06727331 study?

This clinical trial studies the following conditions: Alcohol Use Disorder (AUD).

What interventions are being tested in trial NCT06727331?

The interventions under investigation include: Tirzepatide (DRUG), Saline Placebo (OTHER).

Who is sponsoring clinical trial NCT06727331?

This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06727331 being conducted?

This trial has 2 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.