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Pain: full-pipeline trial registry
106 of 377 indexed Pain trials are currently recruiting.
Corpus placement: #16 of 28,707 conditions by registered trial count.
377 US clinical trials · 106 currently recruiting · #16 of 28,707 conditions by registered trial count
Pain: 377 US clinical trials tracked, 106 recruiting.
Pain is the subject of 377 registered US clinical trials on ClinicalTrials.gov, 106 of them currently open to new participants. 73 are in Phase 3-4 (later-stage) and 79 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 9 of these trials.
Enrollment posture brief
Registry condition pain
OPEN 106 | RECR 28% | LATE 73 | EARLY 79 | RANK #16 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Astigmatism (28% recruiting · 32 trials)
Pain lists 106 open slots (28% of 377 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Pain is recruiting below its size-band peers.
106 of 377 indexed trials (28.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Pain trials is spread across many organizations.
University of Florida accounts for 9 of 377 trials (2.4%). 214 distinct sponsors appear on at least one study for this condition label.
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Typical Pain enrolment sits around 84 participants.
Median target enrolment is 84 among the 375 trials that report a genuine target (sentinel values excluded). 201 of those (53.6%) plan for fewer than 100 participants.
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Pain research is mostly interventional.
319 interventional and 58 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
377 total, page 2 of 8
Training in Evidence-based Treatments in Psycho-Oncology
Massachusetts General Hospital
NCT05674357
Can Medical Cannabis Affect Opioid Use?
Thomas Jefferson University
NCT06206252
Pain After Buffered Vs Non Buffered Articaine
Cleveland Dental Institute
NCT06538233
Music Use in Parturients Admitted to Labor & Delivery
Tufts Medical Center
NCT06969105
Age-dependent Effects of Smoked and Oral Delta-9-THC
University of California, Los Angeles
NCT05865470
ESPBs vs TAPs for Satisfactory Analgesia Following DIEP Surgery
University of Kansas Medical Center
NCT06091241
TENS Analgesia During Outpatient Urethral Bulking for Stress Urinary Incontinence.
University of Rochester
NCT06369922
Chronic Pain Diagnosis and Treatment in Torture Survivors
Weill Medical College of Cornell University
NCT04629963
Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients
Massachusetts General Hospital
NCT07265557
Pain Perception Measurement by EEG and NRS
Cleveland Dental Institute
NCT06510244
A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
Weill Medical College of Cornell University
NCT05081596
Regional Blocks for Lateral Condyle Fractures
University of California, Los Angeles
NCT03796572
Transcutaneous Electrical Nerve Stimulation for Pain Mitigation During Intrauterine Device Placement
Medical University of South Carolina
NCT06991075
Postoperative Pain After Activation of Irrigant
Cleveland Dental Institute
NCT06528574
Reliability of Pupil Response to Acute Pain
Wake Forest University Health Sciences
NCT02628314
Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries
Boston Medical Center
NCT06812247
Phase 1 Study of SBS-147 in Healthy Adults
Sparian Biosciences
NCT07335913
Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals
Virginia Polytechnic Institute and State University
NCT05303415
Opioid-Free Orthopaedics
Emory University
NCT04659317
Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure
Florida State University
NCT06471075
The Role of Virtual Reality During Regional Anesthesia
Cedars-Sinai Medical Center
NCT04163809
Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)
University of Maryland, Baltimore
NCT06214923
Discovery and Analytical Validation of Inflammatory Bio-signatures of the Human Pain Experience
Alan Prossin
NCT05074485
Pain With Dementia
Duke University
NCT06854718
Remimazolam NeuroImaging
Keith M Vogt
NCT07290205
Nitrous Oxide Neuroimaging
Keith M Vogt
NCT06702631
Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery
Duke University
NCT06962306
Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain
The University of Texas Health Science Center, Houston
NCT06968689
Ketamine and Propofol NeuroImaging
Keith M Vogt
NCT07294092
Post-Op Pain Control for Prophylactic Intramedullary Nailing.
St. Louis University
NCT03823534
Integrating Pain-CBT Into an mHealth Analgesic Support Intervention for Patients With Chronic Pain From Advanced Cancers
Dana-Farber Cancer Institute
NCT06722014
Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery
Boston Children's Hospital
NCT06326983
Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
Grace Lim, MD, MS
NCT06767566
Virtual Reality for Pain Management in Burn Patients
Weill Medical College of Cornell University
NCT04685486
Scrambler Therapy With Duloxetine-based Usual Care vs Duloxetine-based Usual Care for Chemotherapy-induced Peripheral Neuropathy.
Fox Chase Cancer Center
NCT06914557
Optimizing Pain Control in Transurethral Resection of the Prostate
Benaroya Research Institute
NCT04102566
Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination
University of Florida
NCT04218409
The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults
University of Florida
NCT05761860
Transdiagnostic Cognitive Biomarkers
University of Minnesota
NCT04864080
Pain Intervention With Needling: Pilot Of Integrated Neuromodulation Techniques
The University of Texas Medical Branch, Galveston
NCT07112404
Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy
Northwell Health
NCT06965452
Association Between Body Composition and Pain in Spinal Cord Injury
University of Miami
NCT05459207
Exploring the Acute and Dynamic Relationships Between Movement and Pain in Older Adults With Musculoskeletal Pain
Indiana University
NCT06886906
Effects of Dronabinol in Opioid Maintained Patients
Yale University
NCT04025359
Pain and Split-belt Motor Learning in Older Adults
University of Delaware
NCT07054840
Contrast and Anesthetic Level With Lumbar Erector Spinae Plan (ESP) Block
University Hospitals Cleveland Medical Center
NCT07174440
THC and CBD: A Controlled Human Study Probing a Harm Reduction Strategy
University of California, Los Angeles
NCT06859710
The Influence of Sleep on Cardiovascular Outcomes
Oregon Health and Science University
NCT06535178
High Potency Cannabis: Acute and Protracted Effects
University of California, Los Angeles
NCT06859723
Augmented Reality For MRI-Guided Interventions
Children's National Research Institute
NCT06224933
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 40 |
| Phase 2 | 39 |
| Phase 3 | 36 |
| Phase 4 | 37 |
Top Sponsors
Named interventions
Most-linked intervention names on Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Pain page
377 registered trials, 106 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 106 Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Florida sponsors the most Pain trials on record, review their full trial history before evaluating a specific study. See University of Florida's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Pain condition card totals 377 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.