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NCT04218409 · ClinicalTrials.gov registry record · Early Phase 1

Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination

A Early Phase 1 study of Pain, sponsored by University of Florida.

Recruiting
Registry status
Early Phase 1
Development phase
45
Enrollment target
1
Study location

NCT04218409 is a Early Phase 1 study of Pain that is actively recruiting participants, run by University of Florida. The registered enrollment target is 45 participants, below the 304-participant average among 374 other Pain trials with a reported enrollment target (85% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT04218409, a Early Phase 1 study of Pain, is actively recruiting participants, sponsored by University of Florida.

RECRUITING
Registry status
Early Phase 1
Development phase
45 participants
Enrollment target
1
Study location

Study Summary

Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, decision-making, and activation of different neural substrates.

Conditions Studied

Pain

Interventions

  • DRUG OxyCODONE 5 mg Oral Tablet
  • DRUG Oxytocin nasal spray
  • OTHER Placebo Oxycodone
  • OTHER Placebo oxytocin
  • DRUG OxyCODONE 2.5 mg Oral Tablet

Study Locations (1)

Florida

  • University of Florida - Gainesville

Trial Details

FieldValue
Enrollment Target 45 participants
Start Date 2021-09-02
Est. Completion 2026-12-31
Phase Early Phase 1

Sponsor

University of Florida

1,106 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04218409

The ClinicalTrials.gov registry entry for NCT04218409 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 304-participant average among 374 other Pain trials with a reported enrollment target (85% lower). The listed sponsor is University of Florida, which has 1,106 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Pain appearing as the primary indexed condition, and to 5 interventions - of which OxyCODONE 5 mg Oral Tablet is the first listed.

NCT04218409 reports 1 study location spanning 1 distinct geographic area - top geographies include Florida.

Frequently Asked Questions

What is clinical trial NCT04218409 about?

NCT04218409 is a clinical study titled "Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination". Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on exper...

What is the current status of trial NCT04218409?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 45 participants. The study started on 2021-09-02. Estimated completion is 2026-12-31.

What conditions does trial NCT04218409 study?

This clinical trial studies the following conditions: Pain.

What interventions are being tested in trial NCT04218409?

The interventions under investigation include: OxyCODONE 5 mg Oral Tablet (DRUG), Oxytocin nasal spray (DRUG), Placebo Oxycodone (OTHER), Placebo oxytocin (OTHER), OxyCODONE 2.5 mg Oral Tablet (DRUG).

Who is sponsoring clinical trial NCT04218409?

This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04218409 being conducted?

This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.