Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Pain: full-pipeline trial registry
106 of 377 indexed Pain trials are currently recruiting.
Corpus placement: #16 of 28,707 conditions by registered trial count.
377 US clinical trials · 106 currently recruiting · #16 of 28,707 conditions by registered trial count
Pain: 377 US clinical trials tracked, 106 recruiting.
Pain is the subject of 377 registered US clinical trials on ClinicalTrials.gov, 106 of them currently open to new participants. 73 are in Phase 3-4 (later-stage) and 79 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 9 of these trials.
Enrollment posture brief
Registry condition pain
OPEN 106 | RECR 28% | LATE 73 | EARLY 79 | RANK #16 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Astigmatism (28% recruiting · 32 trials)
Pain lists 106 open slots (28% of 377 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Pain is recruiting below its size-band peers.
106 of 377 indexed trials (28.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Pain trials is spread across many organizations.
University of Florida accounts for 9 of 377 trials (2.4%). 214 distinct sponsors appear on at least one study for this condition label.
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Typical Pain enrolment sits around 84 participants.
Median target enrolment is 84 among the 375 trials that report a genuine target (sentinel values excluded). 201 of those (53.6%) plan for fewer than 100 participants.
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Pain research is mostly interventional.
319 interventional and 58 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
377 total, page 1 of 8
PAINED: Project Addressing INequities in the Emergency Department
Children's National Research Institute
NCT05488080
Clinical and Scientific Assessment of Pain and Painful Disorders
National Center for Complementary and Integrative Health (NCCIH)
NCT02707029
Behavioral Economic & Staffing Strategies in the ICU
University of Nebraska
NCT06184945
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Duke University
NCT04278404
RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
Boston Scientific Corporation
NCT01719055
M2VA Pain Care Pathway
Yale University
NCT06526143
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial
Major Extremity Trauma Research Consortium
NCT07006675
State-dependent Interoception, Value-based Decision-making, and Introspection
National Institute of Mental Health (NIMH)
NCT05666726
Evaluation of Post-PACU Pain Management in Pediatric Surgery
Columbia University
NCT02352116
Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
National Center for Complementary and Integrative Health (NCCIH)
NCT03258580
Virtual Reality vs. Music Relaxation for Reducing Anxiety and Pain During Breast Biopsies
Jonsson Comprehensive Cancer Center
NCT07310004
AIMS Medical Outcomes Study
Advanced Integrative Medical Science Institute
NCT04512755
Virtual Reality (VR) for Interventional Radiology (IR) Procedures
Children's Hospital Los Angeles
NCT07427862
Neural and Psychological Mechanisms of Pain Perception
National Center for Complementary and Integrative Health (NCCIH)
NCT02446262
Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
University of Pittsburgh
NCT06374238
Anesthetics and Analgesics in Children
Chi Dang Hornik
NCT03427736
Psychophysical Studies of Cancer Therapy Pain
M.D. Anderson Cancer Center
NCT00515060
Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment
Rutgers, The State University of New Jersey
NCT06032559
Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention
Florida State University
NCT07335159
Pervasive Sensing and AI in Intelligent ICU
University of Florida
NCT05127265
Cannabidiol and Older Adult Cannabis Users
University of Colorado, Boulder
NCT06290063
Defense and Veterans Center for Integrative Pain Management (DVCIPM) Pain Registry Biobank
Defense and Veterans Center for Integrative Pain Management
NCT04004286
Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits
University of Utah
NCT06387290
Testing the Pain Clinical Practice Guideline
University of Maryland, Baltimore
NCT05858996
Options for Pain Management Using Nonpharmacological Strategies
VA Office of Research and Development
NCT05563792
Oklahoma Study of Native American Pain Risk III: Stress and Resilience
University of Oklahoma
NCT05723081
Suzetrigine in Total Hip Arthroplasty
Hospital for Special Surgery, New York
NCT07226700
Brief Mindfulness Intervention for Patients at a Free Acute Care Clinic
Florida State University
NCT07025161
The Impact of Gender Affirming Hormone Therapy on Pain In Gender Minority Adults
University of Kansas Medical Center
NCT06939257
Cannabis for Palliative Care in Cancer
University of Colorado, Boulder
NCT06266611
Neural Correlates of Hypoalgesia Driven by Observation
University of Maryland, Baltimore
NCT03897998
Impact of the NeuroCuple Device on Pain Management After Cesarean Delivery
Inova Health Care Services
NCT07185425
Hip Arthroscopy Postoperative Opioid Demands
Rush University Medical Center
NCT04094701
Impact of Art Therapy on Self-Reported Pain and Anxiety Scores of Patients Waiting to Be Seen in the Emergency Department
Stony Brook University
NCT05540106
Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype
Tiffany J. Braley, MD, MS
NCT05269628
Cannabis Effects as a Function of Sex
University of California, Los Angeles
NCT04385082
Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism
Brigham and Women's Hospital
NCT04798469
Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain
University of Oklahoma
NCT07080788
The Warmth, Anticipation, Sensation, Aversion, and Body-part Imaging Study
Trustees of Dartmouth College
NCT04653064
The Effect of Intraoral Transcutaneous Electrical Nerve Stimulation in Orthodontics Pain
University of the Pacific
NCT06573996
Low-Dose Ketamine Infusion During Burn Wound Care
University of Tennessee
NCT06506565
A Randomized Controlled Trial to Assess the Impact of Live and Recorded Music-Based Interventions on Pre-operative Stress, Mood, Pain and Biomarkers, in Neurosurgical Patients (Music-STAR Trial)
M.D. Anderson Cancer Center
NCT06536504
FDG PET/MR Imaging of Peripheral Pain Generators
University of Wisconsin, Madison
NCT06171659
Chronic Pain in Rheumatoid Arthritis
Northwestern University
NCT05038553
State of Hormones Impact Nociceptive Expression
University of Alabama at Birmingham
NCT05787470
Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0
Indiana University
NCT06725550
Measuring Analgesic Interventions
Julia Finkel
NCT03794362
Stress and Pain in People Living With HIV
Yale University
NCT06784908
Pivotal Study on the NOVABLOC System for Patients Undergoing Primary Total Knee Arthroplasty
Synaptrix
NCT07191067
Low-dose Buccal Buprenorphine: Relative Abuse Potential and Analgesia
Vanderbilt University Medical Center
NCT05988710
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 40 |
| Phase 2 | 39 |
| Phase 3 | 36 |
| Phase 4 | 37 |
Top Sponsors
Named interventions
Most-linked intervention names on Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Pain page
377 registered trials, 106 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 106 Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Florida sponsors the most Pain trials on record, review their full trial history before evaluating a specific study. See University of Florida's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Pain condition card totals 377 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.