Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Anxiety

Open-data reference.

367 US clinical trials · 148 currently recruiting

Active & Recent Trials

RECRUITING NA 6,516 participants

My Wellbeing Guide: a Novel Tool for Managing Stress and Improving Quality of Life

Northwestern University

NCT05369429

RECRUITING 5,000 participants

Community Park-Based Programs for Health Promotion: Fit2Play Prospective Cohort Study

Duke University

NCT06595251

RECRUITING 4,000 participants

Evaluation of the PACE/PACENET BHL Clinical Program

University of Pennsylvania

NCT02463266

RECRUITING NA 1,320 participants

Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

Massachusetts General Hospital

NCT06557005

RECRUITING NA 1,000 participants

REstoring Mental Health Through COmmUnity-based Psychological Services in New York City

George Washington University

NCT04913766

RECRUITING 1,000 participants

Community Park-Based Programs for Health Promotion: The Fit2Lead Prospective Cohort Study

Duke University

NCT06596265

RECRUITING NA 1,000 participants

S.T.A.N.D. Alacrity Center Signature Project

University of California, Los Angeles

NCT05591937

RECRUITING NA 700 participants

RCT for Latina Mental Health Using Web-Based Apps

University of California, Los Angeles

NCT06874790

RECRUITING NA 600 participants

Virtual Reality vs. Music Relaxation for Reducing Anxiety and Pain During Breast Biopsies

Jonsson Comprehensive Cancer Center

NCT07310004

RECRUITING 550 participants

External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy

Cefaly Technology

NCT06788977

RECRUITING NA 501 participants

Implementing Team-Based Treatment for Pediatric Anxiety in Community Mental Health Settings

Bradley Hospital

NCT06934525

RECRUITING NA 500 participants

Filipino Family Health Initiative 1.0

Kaiser Permanente

NCT06569303

RECRUITING 500 participants

The Nuestros Días ("Our Days") Study

University of Alabama at Birmingham

NCT06475534

RECRUITING NA 400 participants

Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors

Duke University

NCT06538246

RECRUITING NA 400 participants

SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families

Duke University

NCT06627764

RECRUITING NA 388 participants

Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's

Florida State University

NCT05748613

RECRUITING Phase 2 385 participants

Cannabidiol and Older Adult Cannabis Users

University of Colorado, Boulder

NCT06290063

RECRUITING NA 360 participants

Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program

Penn State University

NCT05789446

RECRUITING NA 325 participants

Promoting Resilience in Early Survivorship Among Adolescents and Young Adults With Cancer

Dana-Farber Cancer Institute

NCT06038318

RECRUITING NA 312 participants

Teachers Leading the Front Lines - North Carolina (Tealeaf-NC)

University of North Carolina, Chapel Hill

NCT06587230

RECRUITING Phase 3 308 participants

P3b Short-term Study of CTN in Patients With ADHD and Comorbid Anxiety

Otsuka Pharmaceutical Development & Commercialization

NCT06973577

RECRUITING NA 300 participants

Change in Social Media Use and Well-being Among College Students Receiving a Two-week Exercise or Mindfulness Intervention

Johns Hopkins Bloomberg School of Public Health

NCT07097545

RECRUITING NA 300 participants

Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic Adults

University of North Carolina, Chapel Hill

NCT06060860

RECRUITING NA 300 participants

Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans

VA Office of Research and Development

NCT06162741

RECRUITING NA 300 participants

Role of Parent Interpretation Bias in the Transmission of Anxiety to Children

Mclean Hospital

NCT05665491

RECRUITING NA 276 participants

Wellness App for Sleep Disturbance in Hematological Cancer Patients

The University of Texas Health Science Center at San Antonio

NCT05294991

RECRUITING NA 250 participants

Personalized Feedback Intervention for Latinx Drinkers With Anxiety

University of Houston

NCT05246202

RECRUITING 250 participants

Evaluation of the H.O.O.V.E.S. Healing Intensives Program

VA Salt Lake City Health Care System

NCT06300255

RECRUITING NA 240 participants

M-O-M-S on the Bayou: Implementation of an Intervention for Mental Health in Pregnancy

Tulane University

NCT05838404

RECRUITING NA 240 participants

Project 2: Optimizing Engagement and Outcomes in STAND Digital Therapy

University of California, Los Angeles

NCT05908565

RECRUITING NA 226 participants

Digital Single Session Intervention for Youth Mental Health

Harvard University

NCT05449002

RECRUITING NA 225 participants

Animal Assisted Therapy in Pediatric Dentistry

University of North Carolina, Chapel Hill

NCT05464888

RECRUITING NA 220 participants

Approach-Avoidance, Computational Framework for Predicting Behavioral Therapy Outcome (AAC-BeT)

Laureate Institute for Brain Research

NCT04426461

RECRUITING NA 212 participants

Testing FIRST in Youth Outpatient Psychotherapy

Harvard University

NCT04725721

RECRUITING NA 202 participants

Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women

University of California, Los Angeles

NCT06646692

RECRUITING 200 participants

Neonatal Neurodevelopmental Outcomes

Baylor College of Medicine

NCT07101757

RECRUITING 200 participants

Collaborative Care for Treatment of Depression and Anxiety

Kaiser Permanente

NCT06556589

RECRUITING NA 188 participants

Effects of Multi-day Interruptions in Sitting on Type 2 Diabetes-relevant Outcomes in Children

University of Southern California

NCT04469790

RECRUITING Phase 2 188 participants

Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer

M.D. Anderson Cancer Center

NCT05474846

RECRUITING Phase 2 185 participants

Cannabis for Palliative Care in Cancer

University of Colorado, Boulder

NCT06266611

RECRUITING NA 180 participants

Brief Interventions for Coping with Distress

Teachers College, Columbia University

NCT05779761

RECRUITING Phase 2 180 participants

Family Acceptance Project Online (Pilot RCT)

University of Michigan

NCT06839859

RECRUITING NA 180 participants

Adverse Adolescent Pathways to Substance Use

University of North Carolina, Chapel Hill

NCT06977178

RECRUITING NA 170 participants

Music Interventions During Wide-Awake Hand Surgery

University of Wisconsin, Madison

NCT05472909

RECRUITING NA 168 participants

Impact of Art Therapy on Self-Reported Pain and Anxiety Scores of Patients Waiting to Be Seen in the Emergency Department

Stony Brook University

NCT05540106

RECRUITING NA 162 participants

mHealth Mindfulness With Patients With Serious Illness and Their Caregivers

Rutgers, The State University of New Jersey

NCT05040711

RECRUITING Phase 3 160 participants

REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss

Wake Forest University Health Sciences

NCT05625360

RECRUITING NA 160 participants

Novel Mental Health Therapies to Improve Military Readiness

David Moss

NCT05887713

RECRUITING NA 160 participants

The Student Wellness and Emotional Growth Resiliency (SWAG-R) Program

Nova Southeastern University

NCT06652503

RECRUITING Phase 2 150 participants

Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women

Cedars-Sinai Medical Center

NCT05552053

RECRUITING NA 150 participants

Radiotherapy Patient Education With Virtual Reality

University of Miami

NCT06506435

RECRUITING NA 150 participants

Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot

Medical University of South Carolina

NCT07390786

RECRUITING NA 150 participants

RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

University of Pittsburgh

NCT05658796

RECRUITING NA 150 participants

Viome Precision Nutritional Programs to Improve Clinical Outcomes for Mental Health Disorders

Viome

NCT06502717

RECRUITING NA 150 participants

Behavioral Health Collaborative Care Model in an ICU Recovery Clinic

Medical University of South Carolina

NCT07372586

RECRUITING Phase 2 146 participants

Behavioral Exposure for Introceptive Tolerance RCT

Rutgers, The State University of New Jersey

NCT05398276

RECRUITING NA 140 participants

Test of Target Engagement of Ambiguity Aversion

Northwestern University

NCT06962527

RECRUITING NA 139 participants

Internet-delivered Cognitive-Behavioral Therapy for Adolescents With Autism and Anxiety

Baylor College of Medicine

NCT06537128

RECRUITING Phase 4 132 participants

Pharmacogenetically-guided Escitalopram Treatment for Pediatric Anxiety: Aiming to Improve Safety and Efficacy (PrEcISE)

University of Cincinnati

NCT04623099

RECRUITING NA 120 participants

SilverCloud as a School-Based Intervention for Vulnerable Youth

NYU Langone Health

NCT06004414

RECRUITING NA 120 participants

Assessing the Effectiveness of Digital Wellness Modules on Perceived Quality of Life

Yale University

NCT05810259

RECRUITING NA 118 participants

Just-in-Time Training for Youth Mentors

University of Minnesota

NCT07129070

RECRUITING NA 110 participants

Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4

University of Michigan

NCT06563310

RECRUITING NA 110 participants

Developing Resilience and Anxiety Management Through the Arts

Case Western Reserve University

NCT07033052

RECRUITING Phase 2 108 participants

Pramipexole to Enhance Social Connections

University of California, San Diego

NCT06269146

RECRUITING NA 106 participants

Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care

Portland State University

NCT06019377

RECRUITING NA 106 participants

Music Use in Parturients Admitted to Labor & Delivery

Tufts Medical Center

NCT06969105

RECRUITING NA 100 participants

Social Support and Reduced Fear Acquisition

University of California, Los Angeles

NCT04564976

RECRUITING Phase 2 100 participants

Psilocybin-Assisted Therapy for Intergenerational Trauma

Rachel Yehuda

NCT06899165

RECRUITING NA 100 participants

Randomized Controlled Trial of a Behavioral Training App

New York University

NCT06447909

RECRUITING NA 100 participants

Fostering Optimal Regulation of Emotion for Prevention of Secondary Trauma (FOREST)

Northwestern University

NCT05942469

RECRUITING NA 100 participants

Social Support and Enhanced Fear Extinction

University of California, Los Angeles

NCT04565041

RECRUITING NA 100 participants

Pilot Study of Virtual Reality Therapy for Students With Anxiety

The University of Texas Health Science Center, Houston

NCT05319509

RECRUITING NA 100 participants

Amplification of Positivity for Alcohol Use

Laureate Institute for Brain Research

NCT06030154

RECRUITING NA 100 participants

Uncertainty and Firearms: Obtaining Secure Storage

Ohio State University

NCT05818696

RECRUITING NA 100 participants

Virtual Patient Groups for Sarcoidosis Associated Fatigue

The Cleveland Clinic

NCT07073963

RECRUITING NA 96 participants

Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons

University of Wisconsin, Madison

NCT06162624

RECRUITING NA 95 participants

Initial Assessment of the Feasibility and Efficacy of a Scalable Digital CBT for Generalized Anxiety and Associated Health Behaviors in a Cardiovascular Disease Population

Boston University Charles River Campus

NCT04895995

RECRUITING NA 90 participants

Mobile Mental Health Stigma Reduction Intervention Among Black Adults

Massachusetts General Hospital

NCT06316804

RECRUITING Phase 4 90 participants

IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED

University of Oklahoma

NCT05934669

RECRUITING NA 85 participants

Expressive Writing on Minority Stressors Among Sexual Minority Veterans

VA Office of Research and Development

NCT05897021

RECRUITING NA 85 participants

Neurobiological Mechanisms of Aging and Stress on Prospective Navigation

Georgia Institute of Technology

NCT03896529

RECRUITING NA 84 participants

Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

Massachusetts General Hospital

NCT07143357

RECRUITING NA 80 participants

Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries

Boston Medical Center

NCT06812247

RECRUITING NA 80 participants

Stress Management Program

Stanford University

NCT06526585

RECRUITING NA 80 participants

Enhancing Purpose and Well-Being Through a Volunteering Experience Connecting Veterans With English Language Learners

University of Michigan

NCT06324383

RECRUITING 80 participants

Potential Benefits of Parent Child Interaction Therapy (PCIT)

University of Florida

NCT06827951

RECRUITING NA 80 participants

The Role of Virtual Reality During Regional Anesthesia

Cedars-Sinai Medical Center

NCT04163809

RECRUITING Phase 2 75 participants

Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

University of California, Los Angeles

NCT06073886

RECRUITING 75 participants

Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series

Reset Medical and Wellness Center

NCT07473505

RECRUITING NA 74 participants

Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families

University of Illinois at Chicago

NCT06261463

RECRUITING Early Phase 1 70 participants

Sleep, Dreaming, and Virtual Reality for Mental Health

Northwestern University

NCT07408206

RECRUITING NA 66 participants

Music-Based Interventions, Aging, Alzheimer's Disease

University of Southern California

NCT06152211

RECRUITING NA 64 participants

Impact of Virtual Reality on Anxiety in Patients Undergoing Interventional Procedures

Northwestern University

NCT05744336

RECRUITING NA 64 participants

Improving Minority Health Through Biofeedback and Stress Reduction

Amelia Saul, PhD, CTRS, BCB

NCT07172152

RECRUITING NA 62 participants

Effects of Virtual Reality Relaxation on the Anxiety Levels

Indiana University

NCT06804967

RECRUITING Phase 4 60 participants

Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)

University of Cincinnati

NCT04245436

RECRUITING NA 60 participants

Managing Anxiety in Pediatric Primary Care (MAPP)

UConn Health

NCT06104904

RECRUITING NA 60 participants

A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression

University of Florida

NCT07112001

RECRUITING NA 60 participants

Brain Activity Changes After Cognitive Behavioral Therapy for Anxiety in Autistic Youth From High-Need Communities

Montclair State University

NCT06904508

Phase Distribution

PhaseTrial count
Early Phase 1 13
Phase 2 25
Phase 3 6
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Anxiety Trial Landscape

ClinicalTrials.gov lists 367 US studies indexed under Anxiety, and 148 of those are currently open to recruitment — roughly 40% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Anxiety shows 15 late-stage studies (Phase 3 and Phase 4 combined) alongside 38 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Anxiety is led by University of California, Los Angeles with 11 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Anxiety?

PlainTrial tracks 367 US clinical trials for Anxiety, of which 148 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Anxiety?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →