Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Pain: full-pipeline trial registry
106 of 377 indexed Pain trials are currently recruiting.
Corpus placement: #16 of 28,707 conditions by registered trial count.
377 US clinical trials · 106 currently recruiting · #16 of 28,707 conditions by registered trial count
Pain: 377 US clinical trials tracked, 106 recruiting.
Pain is the subject of 377 registered US clinical trials on ClinicalTrials.gov, 106 of them currently open to new participants. 73 are in Phase 3-4 (later-stage) and 79 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 9 of these trials.
Enrollment posture brief
Registry condition pain
OPEN 106 | RECR 28% | LATE 73 | EARLY 79 | RANK #16 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Astigmatism (28% recruiting · 32 trials)
Pain lists 106 open slots (28% of 377 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Pain is recruiting below its size-band peers.
106 of 377 indexed trials (28.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Pain trials is spread across many organizations.
University of Florida accounts for 9 of 377 trials (2.4%). 214 distinct sponsors appear on at least one study for this condition label.
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Typical Pain enrolment sits around 84 participants.
Median target enrolment is 84 among the 375 trials that report a genuine target (sentinel values excluded). 201 of those (53.6%) plan for fewer than 100 participants.
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Pain research is mostly interventional.
319 interventional and 58 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
377 total, page 3 of 8
mHealth Intervention for Pain Self Management
Virginia Commonwealth University
NCT07332377
Patient Controlled Administration of Liquid Acetaminophen
Yale University
NCT06498713
Effect of Magnesium on Neuromonitoring
University of California, San Francisco
NCT06975072
Feasibility of a Mindfulness Intervention for Endometriosis Surgery
Milton S. Hershey Medical Center
NCT06141720
Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI
Medical University of South Carolina
NCT05492188
Evaluation of the Excretion of Suzetrigine Into Breast Milk in Healthy Lactating Female Participants
Vertex Pharmaceuticals Incorporated
NCT07378865
Health Disparities on the Labor Floor
University of Alabama at Birmingham
NCT04633824
Examining Bluetooth Haptic Device Use for Pain and Anxiety Reduction in Vascular Access Procedures
Stanford University
NCT06234228
App Delivered Brief Mindfulness Intervention for Surgical Patients
University of Utah
NCT05433389
SPRINT: Signature for Pain Recovery IN Teens
Stanford University
NCT04285112
Neural Mechanisms of Immersive Virtual Reality in Chronic Pain
University of Maryland, Baltimore
NCT04851301
The Effect of Electroacupuncture on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
Dana-Farber Cancer Institute
NCT04917796
Diagnostic and Prognostic Biomarkers for High-impact Chronic Pain: Development and Validation
Stanford University
NCT04994249
The Effect of Yoga on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
Dana-Farber Cancer Institute
NCT05121558
Meaning-Centered Pain Coping Skills Training for Cancer Pain
Duke University
NCT05385965
Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Adults With an Opioid Use Disorder (EXPO; R33 Phase)
Case Western Reserve University
NCT05688410
Development of STEPPT
San Diego State University
NCT06835439
Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)
Hospital for Special Surgery, New York
NCT04082533
Reduced Opioid Prescription After Laparoscopic Hysterectomy
Johns Hopkins University
NCT05548582
Neuromodulation as a Treatment for Chemotherapy-Induced Peripheral Neuropathy
M.D. Anderson Cancer Center
NCT02573766
PENG vs. FIC Block for Hip Fracture ED Patients
Antonios Likourezos
NCT05102760
Effects of Neurofeedback on Neural Function, Neuromodulation, and Chemotherapy-Induced Neuropathic Pain
M.D. Anderson Cancer Center
NCT01278225
Efficacy of Nerve Blockade Performed Prior to Surgical Intervention Versus Following Surgical Intervention
Children's Hospital Medical Center, Cincinnati
NCT02666118
Fundamental Intelligent Building Blocks of the Intensive Care Unit (ICU) of the Future: Intelligent ICU of the Future
University of Florida
NCT03905668
Perineal Massage for Pessary Examinations
University of North Carolina, Chapel Hill
NCT06416982
HELP Pain Training Program
Michigan State University
NCT05698290
Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Opioid Use Disorders ("EXPO" Pilot Trial)
Case Western Reserve University
NCT04736550
Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement
Beth Israel Deaconess Medical Center
NCT05283980
Integrative Medicine in Pain Management in Sickle Cell Disease
Indiana University
NCT05045820
Analgesic and Subjective Effects of Terpenes
University of California, Los Angeles
NCT04451863
Revisiting A Mobile Intervention to Reduce Pain and Improve Health
Wake Forest University
NCT04655001
The Feasibility of the Pray Until Something Happens (PUSH) Intervention-OUTPATIENT
University of Florida
NCT06580067
Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)
Brigham and Women's Hospital
NCT04895306
Role of a CCK Receptor Antagonist Proglumide in Management of Chronic Pancreatitis
Georgetown University
NCT05551858
Pain Perception: Lidocaine Rate/Temp/Buffer
Northwestern University
NCT02823002
Real-World Efficacy of Evoke® Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy in Chronic Pain Patients (ULTRA).
Saint Francis Hospital
NCT06246526
RHA® Redensity With New Anesthetic Agent Perioral Rhytids (PAS)
Teoxane
NCT06378086
AnalgeSiC and appEtite-stimulating Effects of caNnabigerol and THC (ASCENT)
University of California, Los Angeles
NCT04859296
An English/Spanish Mobile Augmented Reality Pain Assessment App for Hispanic/Latino Pediatric Cancer Patients
ALTality
NCT06635434
Denosumab Treatment for Fibrous Dysplasia
National Institute of Dental and Craniofacial Research (NIDCR)
NCT03571191
Phase 2 Study of Tanezumab in Subjects With Moderate to Severe Pain Due to Schwannomatosis
Massachusetts General Hospital
NCT04163419
In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors
The University of Texas Health Science Center at San Antonio
NCT00223366
Water-aided Colonoscopy vs Air Insufflation Colonoscopy in Colorectal Cancer Screening
Presidio Ospedaliero Santa Barbara
NCT02041507
An Intervention to Improve Adolescent Headache Self-management
Stephen F Butler, PhD
NCT02475005
Study of Cabozantinib (XL184) Versus Prednisone in Men With Metastatic Castration-resistant Prostate Cancer Previously Treated With Docetaxel and Abiraterone or MDV3100
Exelixis
NCT01605227
Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer
Wake Forest University Health Sciences
NCT01407770
Radicle Relief 24_RLN: A Study Assessing the Impact of Health and Wellness Products on Pain and Related Health Outcomes.
Radicle Science
NCT07160712
Influence of Genetics in Pain Sensitivity
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00001956
Help Veterans Experience Less Pain Study (HELP-Vets)
US Department of Veterans Affairs
NCT00230932
Effectiveness and Feasibility of Patient Controlled Analgesia in the ED
Albert Einstein College of Medicine
NCT01775371
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 40 |
| Phase 2 | 39 |
| Phase 3 | 36 |
| Phase 4 | 37 |
Top Sponsors
Named interventions
Most-linked intervention names on Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Pain page
377 registered trials, 106 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 106 Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Florida sponsors the most Pain trials on record, review their full trial history before evaluating a specific study. See University of Florida's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Pain condition card totals 377 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.