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Colorectal Cancer: early-phase trial registry
154 of 382 indexed Colorectal Cancer trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #14 of 28,963 conditions by registered trial count.
382 US clinical trials · 154 currently recruiting · #14 of 28,963 conditions by registered trial count
Colorectal Cancer: 382 US clinical trials tracked, 154 recruiting.
Colorectal Cancer is the subject of 382 registered US clinical trials on ClinicalTrials.gov, 154 of them currently open to new participants. 12 are in Phase 3-4 (later-stage) and 196 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 22 of these trials.
Open enrollment, early-phase tilt
Colorectal Cancer has 382 registered US clinical trials, 154 of them open to new participants right now, about 40% of the total.
- 154
- recruiting participants now
- 40%
- of trials open to enrollment
- 12
- in Phase 3-4 (later-stage)
- 22
- top sponsor: Memorial Sloan Kettering Cancer Center
Corpus placement: #14 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Colorectal Cancer on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
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Colorectal Cancer is recruiting above its size-band peers.
154 of 382 indexed trials (40.3%) are open to enrollment, against a 37.2% average across 135 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Colorectal Cancer trials is spread across many organizations.
Memorial Sloan Kettering Cancer Center accounts for 22 of 382 trials (5.8%). 217 distinct sponsors appear on at least one study for this condition label.
-
Typical Colorectal Cancer enrolment sits around 132 participants.
Median target enrolment is 132 among the 370 trials that report a genuine target (sentinel values excluded). 157 of those (42.4%) plan for fewer than 100 participants.
-
Colorectal Cancer research is mostly interventional.
315 interventional and 67 observational studies make up this index (82.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
382 total, page 1 of 8
Surveillance Colonoscopy in Older Adults: The SurvOlderAdults Study
VA Office of Research and Development
NCT05994482
A Prospective, Multi-center, Observational Study for Signal-C Test Evaluation
Universal Diagnostics
NCT06059963
Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
Dartmouth-Hitchcock Medical Center
NCT05612347
Evaluation for NCI Surgery Branch Clinical Research Protocols
National Cancer Institute (NCI)
NCT00001823
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
Adela
NCT05366881
Collection of Samples From the United States Population for Optimization and Evaluation of Colorectal Cancer (CRC) Plasma Circulating Free-DNA (cfDNA) Marker Panel Performance
Universal Diagnostics
NCT07310446
Community Partnership for Telehealth Solutions to Counter Misinformation and Achieve Equity
University of Arizona
NCT06542835
ARGONAUT: Stool and Blood Sample Bank for Cancer Patients
Persephone Biosciences
NCT04638751
ColoCare Study - Colorectal Cancer Cohort
University of Utah
NCT02328677
Gastrointestinal Biomarkers in Tissue and Biological Fluid Samples From Colorectal Cancer Patients
Vanderbilt University Medical Center
NCT00899626
Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer
San Raffaele University
NCT05732623
Early Detection of Advanced Adenomas and Colorectal Cancer
City of Hope Medical Center
NCT06342440
Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies
Elephas
NCT07327489
Collection of Information to Better Understand Young Onset Colorectal Cancer
Memorial Sloan Kettering Cancer Center
NCT04489238
Urine Metabolites in the Diagnosis of Disease
Luventix
NCT06710067
A Cross-sectional Partnership to Improve Prevention and Health Equity Among African Americans
University of Nebraska
NCT05903885
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
Revolution Medicines
NCT06445062
Discovering New Targets for Colorectal and Endometrial Cancer Risk Reduction
Weill Medical College of Cornell University
NCT06096688
Video Education With Result Dependent dIsclosure
Dana-Farber Cancer Institute
NCT05225428
Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics
M.D. Anderson Cancer Center
NCT05694559
Identifying Underserved Individuals inTexas With Hereditary Cancer Risk Using Mobile Mammography Units and Telegenetics.
M.D. Anderson Cancer Center
NCT05649072
Preserving Fertility After Colorectal Cancer Study
Andreana Holowatyj, PhD, MSCI
NCT05239338
mPATH-Cloud for Colorectal Cancer Screening
UNC Lineberger Comprehensive Cancer Center
NCT06441487
Community Health Workers United to Reduce Colorectal Cancer and Cardiovascular Disease Among People at Higher Risk
Columbia University
NCT05174286
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Boehringer Ingelheim
NCT06324357
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
Eli Lilly and Company
NCT06586515
Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers
University of Missouri-Columbia
NCT02838836
Liquid Biopsy for Early Detection of Colorectal Cancer Using Circular RNA
City of Hope Medical Center
NCT07224789
FOG-001 in Locally Advanced or Metastatic Solid Tumors
Parabilis Medicines
NCT05919264
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
Revolution Medicines
NCT06128551
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Merus B.V.
NCT03526835
PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival
UNC Lineberger Comprehensive Cancer Center
NCT06896162
A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
A2 Biotherapeutics
NCT06051695
SIBYL: obServation of Therapy Response With lIquid BiopsY evaLuation
Guardant Health
NCT05935384
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
AstraZeneca
NCT05489211
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors
Genentech
NCT05581004
Developing New Educational Materials About Genetic Testing for a Diverse Group of Cancer Patients
Memorial Sloan Kettering Cancer Center
NCT04751435
Observational Basket Trial to Collect Tissue to Develop and Train a Live Tumor Diagnostic Platform
Elephas
NCT05520099
A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors
ArriVent BioPharma
NCT07066657
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
Frontier Medicines Corporation
NCT06244771
Early Onset Colorectal Cancer Detection
City of Hope Medical Center
NCT06342401
Stage II/III Colorectal Cancer Recurrence
City of Hope Medical Center
NCT06314958
Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing Surgical Resection
University of Colorado, Denver
NCT05517811
FITting Non-invasive Tests in Lynch Syndrome Surveillance
University of Chicago
NCT06898996
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
Astellas Pharma
NCT07094204
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
IDEAYA Biosciences
NCT03947385
Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow
University of Missouri-Columbia
NCT03551951
Precise Oncology Interventions in Nutrition and Training (OnPoint)
University of Miami
NCT06534918
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
PMV Pharmaceuticals
NCT04585750
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
Wake Forest University Health Sciences
NCT03998202
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 128 |
| Phase 2 | 68 |
| Phase 3 | 9 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Colorectal Cancer right now
154 recruiting of 382 indexed (40% open).
Phase mix: 12 late (III/IV) vs 196 early (I/II) (early-phase heavy).
Top sponsor: Memorial Sloan Kettering Cancer Center (22 trials), 9 others listed. 50 shown below, recruiting first. #14 of 28,963 conditions by registered trial count.
How open-enrollment share is computed
Open share is recruiting_count divided by trial_count for this condition label in the public registry export. Status can change between pulls; treat the figure as a snapshot of research attention, not treatment availability.
Frequently Asked Questions
How many clinical trials are there for Colorectal Cancer?
PlainTrial tracks 382 US clinical trials for Colorectal Cancer, of which 154 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Colorectal Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.