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NCT07097506 · ClinicalTrials.gov registry record · Phase 2
Effect of Ketone Esters on Liver Fat Content and Metabolic Function
A Phase 2 study of Obesity and MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT07097506: Recruiting Phase 2 study of Obesity and MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, sponsored by Washington University School of Medicine.
NCT07097506 is a Phase 2 study of Obesity and MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 40 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07097506, a Phase 2 study of Obesity and MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to determine whether ingestion of a ketone ester drink helps improve liver health and blood glucose control. Ketones are a type of energy source made by the body during times of weight loss, low carbohydrate intake and starvation. People enrolled in this study will be randomly assigned (by chance, like the flip of a coin) to one of two groups: Group 1: Ketone ester drink consumed daily for 6 weeks. Group 2: Placebo drink consumed daily for 6 weeks.
Primary Outcome
Intrahepatic triglyceride content will be assessed by magnetic resonance imagining (MRI)
Conditions Studied
Interventions
- OTHER Placebo
- DRUG bis-octanoyl (R)-1,3-butanediol (C8 ketone di-ester)
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-09-26 |
| Est. Completion | 2027-12-31 |
| Phase | Phase 2 |
What NCT07097506 shows while recruiting
NCT07097506 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (95% lower).
The record links to 3 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT07097506 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT07097506 about?
NCT07097506 is a clinical study titled "Effect of Ketone Esters on Liver Fat Content and Metabolic Function". The goal of this clinical trial is to determine whether ingestion of a ketone ester drink helps improve liver health and blood glucose control. Ketones are a type of energy source made by the body during times of weight loss, low carbohydrate intake and starvation. People enrolled in this study wil...
What is the current status of trial NCT07097506?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2025-09-26. Estimated completion is 2027-12-31.
What conditions does trial NCT07097506 study?
This clinical trial studies the following conditions: Obesity, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Overweight (BMI > 25).
What interventions are being tested in trial NCT07097506?
The interventions under investigation include: Placebo (OTHER), bis-octanoyl (R)-1,3-butanediol (C8 ketone di-ester) (DRUG).
Who is sponsoring clinical trial NCT07097506?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07097506 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obesity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07097506's enrollment target sits among peer trials
40 778th of 1053 higher than 249 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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