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NCT06571474 · ClinicalTrials.gov registry record
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)
A clinical trial of Healthy and Obesity, sponsored by Bettina Mittendorfer.
- Recruiting
- Registry status
- 60
- Enrollment target
- 1
- Study location
NCT06571474: Recruiting study of Healthy and Obesity, sponsored by Bettina Mittendorfer.
NCT06571474 is a study of Healthy and Obesity that is actively recruiting participants, run by Bettina Mittendorfer. The registered enrollment target is 60 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06571474, a study of Healthy and Obesity, is actively recruiting participants, sponsored by Bettina Mittendorfer.
- RECRUITING
- Registry status
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals. Both groups will have: * screening visit * imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and magnetic resonance spectroscopy \[MRS\] scans) * Overnight visit with intravenous infusion (IV), muscle, and fat tissue biopsies
Primary Outcome
Sensitivity assessed as insulin-mediated glucose disposal during a hyperinsulinemic-euglycemic clamp procedure
Conditions Studied
Study Locations (1)
Missouri
- University of Missouri School of Medicine - Columbia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2024-08-01 |
| Est. Completion | 2028-03 |
What NCT06571474 shows while recruiting
NCT06571474 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (91% lower).
The record links to 4 conditions, with Healthy appearing as the primary indexed condition, and to 0 interventions.
NCT06571474 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT06571474 about?
NCT06571474 is a clinical study titled "Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)". The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnor...
What is the current status of trial NCT06571474?
This trial is currently recruiting. The enrollment target is 60 participants. The study started on 2024-08-01. Estimated completion is 2028-03.
What conditions does trial NCT06571474 study?
This clinical trial studies the following conditions: Healthy, Obesity, Diabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease.
Who is sponsoring clinical trial NCT06571474?
This trial is sponsored by Bettina Mittendorfer, which has 4 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06571474 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06571474's enrollment target sits among peer trials
60 369th of 1090 higher than 689 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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