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Aleniglipron Phase 2 in Type 2 Diabetes Mellitus
NCT07400588 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to assess the safety and tolerability of aleniglipron at doses up to 240 mg once daily (QD) in participants with T2DM who are living with obesity (body mass index \[BMI\] ≥ 30 kg/m2) or overweight (BMI ≥ 27 kg/m2).
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Aleniglipron
Study Locations (17)
Texas
- Research Site — Austin
- Research Site — Austin
- Research Site — DeSoto
- Research Site — Houston
- Research Site — Mesquite
- Research Site — San Antonio
- Research Site — San Antonio
- Research Site — San Antonio
- Research Site — Tomball
California
- Research Site — Lake Forest
- Research Site — Lomita
Tennessee
- Research Site — Chattanooga
- Research Site — Knoxville
Alabama
- Research Site — Anniston
Missouri
- Research Site — Hazelwood
Ohio
- Research Site — Columbus
South Carolina
- Research Site — Moncks Corner
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-12-01 |
| Est. Completion | 2026-11 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07400588
The ClinicalTrials.gov registry entry for NCT07400588 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics, which has 4 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07400588 reports 17 study locations spanning 7 distinct geographic areas — top geographies include Texas, California, Tennessee. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07400588 about?
NCT07400588 is a clinical study titled "Aleniglipron Phase 2 in Type 2 Diabetes Mellitus". The purpose of this study is to assess the safety and tolerability of aleniglipron at doses up to 240 mg once daily (QD) in participants with T2DM who are living with obesity (body mass index \[BMI\] ≥ 30 kg/m2) or overweight (BMI ≥ 27 kg/m2).
What is the current status of trial NCT07400588?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 50 participants. The study started on 2025-12-01. Estimated completion is 2026-11.
What conditions does trial NCT07400588 study?
This clinical trial studies the following conditions: Obesity, Weight Loss, Obese, Obesity Type 2 Diabetes Mellitus. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07400588?
The interventions under investigation include: Placebo (DRUG), Aleniglipron (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07400588?
This trial is sponsored by Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics, which has 4 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07400588 being conducted?
This trial has 17 study locations across Alabama, California, Missouri, Ohio, South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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