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NCT05795634 · ClinicalTrials.gov registry record · NA
Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease
A NA study of Alzheimer Disease and Mild Cognitive Impairment, sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- NA
- Development phase
- 240
- Enrollment target
- 1
- Study location
NCT05795634: Recruiting NA study of Alzheimer Disease and Mild Cognitive Impairment, sponsored by Johns Hopkins University.
NCT05795634 is a NA study of Alzheimer Disease and Mild Cognitive Impairment that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 240 participants, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05795634, a NA study of Alzheimer Disease and Mild Cognitive Impairment, is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- NA
- Development phase
- 240 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn about how genetics and the response to stress predicts cognitive decline in individuals with mild cognitive impairment. The main question\[s\] it aims to answer are: * Does the hormone response to acute stress predict the degree of cognitive impairment following acute stress? * Do genes associated with the risk for Alzheimer's disease influence the relationship between stress hormone response to stress and cognitive impairment following stress? * Do cognitive impairment following acute stress and genes associated with the risk for Alzheimer's disease predict cognitive decline and change in biomarkers for Alzheimer's disease 2 years later? Participants will have 3 in-person study visits. The first 2 will occur at baseline and the 3rd visit will occur 2 years later. During the visits, participants will provide blood and saliva samples, undergo a 10-minute social stress procedure, complete questionnaires, and take tests of memory and other thinking skills. Someone who knows the participant (a "study partner") will be asked questions about the participant's daily functioning at the first and 3rd study visits.
Primary Outcome
Change in the mean composite score of the following memory tests: Neuropsychological Assessment Battery Word List Memory test, Morris Revision test, and a computerized Pattern Separation Task, with higher composite score indicating better memory
Conditions Studied
Interventions
- BEHAVIORAL Trier Social Stress Test
Study Locations (1)
Maryland
- Johns Hopkins School of Medicine - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2023-03-01 |
| Est. Completion | 2029-03-01 |
| Phase | NA |
What NCT05795634 shows while recruiting
NCT05795634 is an interventional study that assigns participants to a tested intervention. The registered 240 participants enrollment target is mid-sized for trials with a published cap, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (91% lower).
The record links to 2 conditions, with Alzheimer Disease appearing as the primary indexed condition, and to 1 intervention - of which Trier Social Stress Test is the first listed.
NCT05795634 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT05795634 about?
NCT05795634 is a clinical study titled "Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease". The goal of this clinical trial is to learn about how genetics and the response to stress predicts cognitive decline in individuals with mild cognitive impairment. The main question\[s\] it aims to answer are: * Does the hormone response to acute stress predict the degree of cognitive impairment f...
What is the current status of trial NCT05795634?
This trial is currently recruiting. It is a NA study. The enrollment target is 240 participants. The study started on 2023-03-01. Estimated completion is 2029-03-01.
What conditions does trial NCT05795634 study?
This clinical trial studies the following conditions: Alzheimer Disease, Mild Cognitive Impairment.
What interventions are being tested in trial NCT05795634?
The interventions under investigation include: Trier Social Stress Test (BEHAVIORAL).
Who is sponsoring clinical trial NCT05795634?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05795634 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alzheimer Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05795634's enrollment target sits among peer trials
240 94th of 306 higher than 209 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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