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NCT04124029 · ClinicalTrials.gov registry record

Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)

A clinical trial of Mild Cognitive Impairment and Mild Traumatic Brain Injury, sponsored by VA Office of Research and Development.

Recruiting
Registry status
800
Enrollment target
1
Study location

NCT04124029: Recruiting study of Mild Cognitive Impairment and Mild Traumatic Brain Injury, sponsored by VA Office of Research and Development.

NCT04124029 is a study of Mild Cognitive Impairment and Mild Traumatic Brain Injury that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 800 participants, below the 1,267-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (37% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04124029, a study of Mild Cognitive Impairment and Mild Traumatic Brain Injury, is actively recruiting participants, sponsored by VA Office of Research and Development.

RECRUITING
Registry status
800 participants
Enrollment target
1
Study location

Study Summary

This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after brain injury and in dementia.

Primary Outcome

The work proposed will allow exploration of the relationships between behavioral, event-related potential (ERP), MRI, and cerebrospinal fluid (CSF) measures at a variety of points along the disease continuum and will allow for future longitudinal studies in this cohort

Conditions Studied

Mild Cognitive Impairment Mild Traumatic Brain Injury Moderate Traumatic Brain Injury

Interventions

  • DEVICE No Intervention is used for this study but all subjects will be asked to complete EEG testing and an MRI scan.
  • PROCEDURE No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure.

Study Locations (1)

Massachusetts

  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA - Boston

Trial Details

FieldValue
Enrollment Target 800 participants
Start Date 2021-07-01
Est. Completion 2026-06-30
VA Office of Research and Development

1,668 total trials

What NCT04124029 shows while recruiting

NCT04124029 is an observational study that tracks outcomes without assigning an intervention. The registered 800 participants enrollment target is mid-sized for trials with a published cap, below the 1,267-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (37% lower).

The record links to 3 conditions, with Mild Cognitive Impairment appearing as the primary indexed condition, and to 2 interventions - of which No Intervention is used for this study but all subjects will be asked to complete EEG testing and an MRI scan. is the first listed.

NCT04124029 reports a single indexed study location in Massachusetts.

Frequently Asked Questions

What is clinical trial NCT04124029 about?

NCT04124029 is a clinical study titled "Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)". This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after brain injury and in dementia.

What is the current status of trial NCT04124029?

This trial is currently recruiting. The enrollment target is 800 participants. The study started on 2021-07-01. Estimated completion is 2026-06-30.

What conditions does trial NCT04124029 study?

This clinical trial studies the following conditions: Mild Cognitive Impairment, Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury.

What interventions are being tested in trial NCT04124029?

The interventions under investigation include: No Intervention is used for this study but all subjects will be asked to complete EEG testing and an MRI scan. (DEVICE), No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure. (PROCEDURE).

Who is sponsoring clinical trial NCT04124029?

This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04124029 being conducted?

This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Mild Cognitive Impairment

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04124029's enrollment target sits among peer trials

800 18th of 205 higher than 188 of 205 other Mild Cognitive Impairment trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Mild Cognitive Impairment trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT04124029

Source: ClinicalTrials.gov NCT04124029, the US trial registry maintained by the National Library of Medicine. NCT04124029 (mid enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.