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NCT04938349 · ClinicalTrials.gov registry record · NA

Dual Task Perturbation Training for OAwMCI

A NA study of Mild Cognitive Impairment and Old Age; Debility, sponsored by University of Illinois at Chicago.

Recruiting
Registry status
NA
Development phase
142
Enrollment target
1
Study location

NCT04938349 is a NA study of Mild Cognitive Impairment and Old Age; Debility that is actively recruiting participants, run by University of Illinois at Chicago. The registered enrollment target is 142 participants, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT04938349, a NA study of Mild Cognitive Impairment and Old Age; Debility, is actively recruiting participants, sponsored by University of Illinois at Chicago.

RECRUITING
Registry status
NA
Development phase
142 participants
Enrollment target
1
Study location

Study Summary

Studies have determined that compared to cognitively intact older adults (CIOA), older adults with mild cognitive impairment (OAwMCI) exhibit more pronounced balance and gait impairments which lead to an increased risk of falls and mobility decline. Such impairments are evident during dual-tasking (i.e., simultaneous performance of cognitive and motor task) and OAwMCI have demonstrated an increased cognitive-motor interference (deteriorated performance of either or both cognitive/motor task). Furthermore, our preliminary laboratory findings indicate that compared to CIOA, OAwMCI in response to large-magnitude treadmill perturbations exhibits poor reactive responses (first line of defense against balance loss) and are unable to modulate their responses as the magnitude of perturbation increases. Despite that conventional exercise methods offer beneficial effects; they comprise of self-initiated task-specific exercises and may not focus on training reactive responses. Additionally, due to the presence of subtle balance and gait deficits, clinical measures used may not be sensitive enough to determine the risk of fall post-training. Furthermore, these training methods incorporate multiple sessions due to which adherence to exercise training is difficult with only a fraction of the older adults benefiting from it. Therefore, it is essential to incorporate a task-specific strategy that promotes factors associated with falling like balance control, muscular responses, coordination of limbs, and cognition through which OAwMCI may acquire maximum benefits to prevent a balance loss. One feasible method, which harnesses technology that can be used to deliver balance disturbances either while standing or walking in a consistent and controlled manner, is via a custom-based motorized treadmill. The scientific rigor from preliminary studies has reported a successful reduction of falls through a single session exposing CIOA to multiple treadmill-induced perturbations during gait a

Interventions

  • BEHAVIORAL Dual task perturbation training

Study Locations (1)

Illinois

  • University of Illinois at Chicago - Chicago

Trial Details

FieldValue
Enrollment Target 142 participants
Start Date 2021-09-14
Est. Completion 2026-08-31
Phase NA

Sponsor

University of Illinois at Chicago

430 total trials

What the Registry Record Tells You About NCT04938349

The ClinicalTrials.gov registry entry for NCT04938349 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 142 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (89% lower). The listed sponsor is University of Illinois at Chicago, which has 430 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Mild Cognitive Impairment appearing as the primary indexed condition, and to 1 intervention - of which Dual task perturbation training is the first listed.

NCT04938349 reports 1 study location spanning 1 distinct geographic area - top geographies include Illinois.

Frequently Asked Questions

What is clinical trial NCT04938349 about?

NCT04938349 is a clinical study titled "Dual Task Perturbation Training for OAwMCI". Studies have determined that compared to cognitively intact older adults (CIOA), older adults with mild cognitive impairment (OAwMCI) exhibit more pronounced balance and gait impairments which lead to an increased risk of falls and mobility decline. Such impairments are evident during dual-tasking (...

What is the current status of trial NCT04938349?

This trial is currently recruiting. It is a NA study. The enrollment target is 142 participants. The study started on 2021-09-14. Estimated completion is 2026-08-31.

What conditions does trial NCT04938349 study?

This clinical trial studies the following conditions: Mild Cognitive Impairment, Old Age; Debility.

What interventions are being tested in trial NCT04938349?

The interventions under investigation include: Dual task perturbation training (BEHAVIORAL).

Who is sponsoring clinical trial NCT04938349?

This trial is sponsored by University of Illinois at Chicago, which has 430 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04938349 being conducted?

This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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