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NCT05907343 · ClinicalTrials.gov registry record · NA
Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline
A NA study of Mild Cognitive Impairment, sponsored by University of Texas at Austin.
- Recruiting
- Registry status
- NA
- Development phase
- 180
- Enrollment target
- 1
- Study location
NCT05907343: Recruiting NA study of Mild Cognitive Impairment, sponsored by University of Texas at Austin.
NCT05907343 is a NA study of Mild Cognitive Impairment that is actively recruiting participants, run by University of Texas at Austin. The registered enrollment target is 180 participants, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05907343, a NA study of Mild Cognitive Impairment, is actively recruiting participants, sponsored by University of Texas at Austin.
- RECRUITING
- Registry status
- NA
- Development phase
- 180 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical study is to investigate the effectiveness of non-invasive stimulation to enhance cognitive control abilities in cognitively healthy adults and older adults diagnosed with mild cognitive disorder (MCI). The main questions it aims to answer are: * whether it is possible to restore various cognitive functions in older adults diagnosed with MCI by delivering theta burst stimulation (TBS), a form of transcranial magnetic stimulation, and * whether closed-loop TBS is able to induce therapeutic benefits that outperform open-loop TBS. Participants play a cognitive video game while a brain-computer interface (BCI) analyzes their electroencephalogram (EEG) signals and decodes the presence or absence of the contingent negative variation (CNV) potential, a marker of cognitive control. The BCI triggers TBS when its outputs indicate that the participant is not engaged properly in the video game. Researchers will compare the effects of sham, closed-loop, and open-loop TBS using the outcome metrics described below to see how much cognitive restorations is achievable with each stimulation modality.
Primary Outcome
NIH Toolbox - Cognition Battery: A computerized battery assessing multiple cognitive domains. The primary metric for all subtests is the age- and education-adjusted T-score (normative mean = 50, standard deviation = 10). Includes: Dimensional Change Card Sort, Face-Name Associative Memory Test, Flanker Inhibitory Control and Attention Test, Picture Sequence Memory Test, Rey Auditory Verbal Learning Test, Pattern Comparison Processing Speed Test
Conditions Studied
Interventions
- DEVICE Sham TBS
- DEVICE Closed-loop TBS
- DEVICE Open-loop TBS
Study Locations (1)
Texas
- Health Discovery Building - Austin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2023-05-31 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
What NCT05907343 shows while recruiting
NCT05907343 is an interventional study that assigns participants to a tested intervention. The registered 180 participants enrollment target is mid-sized for trials with a published cap, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (86% lower).
The record links to 1 condition, with Mild Cognitive Impairment appearing as the primary indexed condition, and to 3 interventions - of which Sham TBS is the first listed.
NCT05907343 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05907343 about?
NCT05907343 is a clinical study titled "Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline". The goal of this clinical study is to investigate the effectiveness of non-invasive stimulation to enhance cognitive control abilities in cognitively healthy adults and older adults diagnosed with mild cognitive disorder (MCI). The main questions it aims to answer are: * whether it is possible to r...
What is the current status of trial NCT05907343?
This trial is currently recruiting. It is a NA study. The enrollment target is 180 participants. The study started on 2023-05-31. Estimated completion is 2026-12-31.
What conditions does trial NCT05907343 study?
This clinical trial studies the following conditions: Mild Cognitive Impairment.
What interventions are being tested in trial NCT05907343?
The interventions under investigation include: Sham TBS (DEVICE), Closed-loop TBS (DEVICE), Open-loop TBS (DEVICE).
Who is sponsoring clinical trial NCT05907343?
This trial is sponsored by University of Texas at Austin, which has 257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05907343 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05907343's enrollment target sits among peer trials
180 56th of 205 higher than 148 of 205 other Mild Cognitive Impairment trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mild Cognitive Impairment trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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