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NCT05907343 · ClinicalTrials.gov registry record · NA

Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline

A NA study of Mild Cognitive Impairment, sponsored by University of Texas at Austin.

Recruiting
Registry status
NA
Development phase
180
Enrollment target
1
Study location

NCT05907343 is a NA study of Mild Cognitive Impairment that is actively recruiting participants, run by University of Texas at Austin. The registered enrollment target is 180 participants, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05907343, a NA study of Mild Cognitive Impairment, is actively recruiting participants, sponsored by University of Texas at Austin.

RECRUITING
Registry status
NA
Development phase
180 participants
Enrollment target
1
Study location

Study Summary

The goal of this clinical study is to investigate the effectiveness of non-invasive stimulation to enhance cognitive control abilities in cognitively healthy adults and older adults diagnosed with mild cognitive disorder (MCI). The main questions it aims to answer are: * whether it is possible to restore various cognitive functions in older adults diagnosed with MCI by delivering theta burst stimulation (TBS), a form of transcranial magnetic stimulation, and * whether closed-loop TBS is able to induce therapeutic benefits that outperform open-loop TBS. Participants play a cognitive video game while a brain-computer interface (BCI) analyzes their electroencephalogram (EEG) signals and decodes the presence or absence of the contingent negative variation (CNV) potential, a marker of cognitive control. The BCI triggers TBS when its outputs indicate that the participant is not engaged properly in the video game. Researchers will compare the effects of sham, closed-loop, and open-loop TBS using the outcome metrics described below to see how much cognitive restorations is achievable with each stimulation modality.

Conditions Studied

Mild Cognitive Impairment

Interventions

  • DEVICE Sham TBS
  • DEVICE Closed-loop TBS
  • DEVICE Open-loop TBS

Study Locations (1)

Texas

  • Health Discovery Building - Austin

Trial Details

FieldValue
Enrollment Target 180 participants
Start Date 2023-05-31
Est. Completion 2026-12-31
Phase NA

Sponsor

University of Texas at Austin

257 total trials

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What the Registry Record Tells You About NCT05907343

The ClinicalTrials.gov registry entry for NCT05907343 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (86% lower). The listed sponsor is University of Texas at Austin, which has 257 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Mild Cognitive Impairment appearing as the primary indexed condition, and to 3 interventions - of which Sham TBS is the first listed.

NCT05907343 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.

Frequently Asked Questions

What is clinical trial NCT05907343 about?

NCT05907343 is a clinical study titled "Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline". The goal of this clinical study is to investigate the effectiveness of non-invasive stimulation to enhance cognitive control abilities in cognitively healthy adults and older adults diagnosed with mild cognitive disorder (MCI). The main questions it aims to answer are: * whether it is possible to r...

What is the current status of trial NCT05907343?

This trial is currently recruiting. It is a NA study. The enrollment target is 180 participants. The study started on 2023-05-31. Estimated completion is 2026-12-31.

What conditions does trial NCT05907343 study?

This clinical trial studies the following conditions: Mild Cognitive Impairment.

What interventions are being tested in trial NCT05907343?

The interventions under investigation include: Sham TBS (DEVICE), Closed-loop TBS (DEVICE), Open-loop TBS (DEVICE).

Who is sponsoring clinical trial NCT05907343?

This trial is sponsored by University of Texas at Austin, which has 257 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05907343 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.