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NCT04171323 · ClinicalTrials.gov registry record · NA

The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia

A NA study of Mild Cognitive Impairment and Dementia, sponsored by University of Alabama at Birmingham.

Recruiting
Registry status
NA
Development phase
1,305
Enrollment target
6
Study locations

NCT04171323: Recruiting NA study of Mild Cognitive Impairment and Dementia, sponsored by University of Alabama at Birmingham.

NCT04171323 is a NA study of Mild Cognitive Impairment and Dementia that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 1,305 participants, roughly in line with the 1,264-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target. The trial reports 6 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04171323, a NA study of Mild Cognitive Impairment and Dementia, is actively recruiting participants, sponsored by University of Alabama at Birmingham.

RECRUITING
Registry status
NA
Development phase
1,305 participants
Enrollment target
6
Study locations

Study Summary

Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination of CT exercises as compared to cognitive stimulation (which will serve as a stringent, active control) to modify the functional trajectories of older adults' with MCI, who are at high risk for dementia. The primary objective of the U01 phase was to design and pilot-test an adaptive, randomized clinical trial (RCT) of cognitive training (CT) combinations aimed to enhance performance of instrumental activities of daily living (IADL) among persons with mild cognitive impairment (MCI). In the R01 phase, the objective is to identify the best combination of CT exercises to delay dementia onset among persons with MCI. The longitudinal endpoint goal is reducing incident dementia. The primary aim of the study is to determine which CT combination has the best probability to delay dementia by producing the largest IADL improvements. The study further aims to explore neuroimaging and novel blood-based biomarkers.

Primary Outcome

Clinical diagnosis of dementia

Conditions Studied

Mild Cognitive Impairment Dementia Age-related Cognitive Decline

Interventions

  • BEHAVIORAL Cognitive Training
  • BEHAVIORAL Computerized Cognitive Stimulation

Study Locations (6)

Florida

  • University of Florida - Gainesville
  • Active Mind Study - Tampa

South Carolina

  • Clemson University - Greenville
  • Clemson University - Seneca

California

  • University of California San Francisco - San Francisco

Minnesota

  • University of Minnesota - Minneapolis

Trial Details

FieldValue
Enrollment Target 1,305 participants
Start Date 2020-03-03
Est. Completion 2028-08-31
Phase NA
University of Alabama at Birmingham

1,160 total trials

What NCT04171323 shows while recruiting

NCT04171323 is an interventional study that assigns participants to a tested intervention. Its 1,305 participants enrollment target places it among the larger protocols in the corpus, roughly in line with the 1,264-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target.

The record links to 3 conditions, with Mild Cognitive Impairment appearing as the primary indexed condition, and to 2 interventions - of which Cognitive Training is the first listed.

NCT04171323 lists 6 locations in 4 states (Florida, South Carolina, California).

Frequently Asked Questions

What is clinical trial NCT04171323 about?

NCT04171323 is a clinical study titled "The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia". Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination of CT exercises as compared to cognitive stimulati...

What is the current status of trial NCT04171323?

This trial is currently recruiting. It is a NA study. The enrollment target is 1,305 participants. The study started on 2020-03-03. Estimated completion is 2028-08-31.

What conditions does trial NCT04171323 study?

This clinical trial studies the following conditions: Mild Cognitive Impairment, Dementia, Age-related Cognitive Decline.

What interventions are being tested in trial NCT04171323?

The interventions under investigation include: Cognitive Training (BEHAVIORAL), Computerized Cognitive Stimulation (BEHAVIORAL).

Who is sponsoring clinical trial NCT04171323?

This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04171323 being conducted?

This trial has 6 study locations across California, Florida, Minnesota, South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Mild Cognitive Impairment

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04171323's enrollment target sits among peer trials

1,305 11th of 205 higher than 195 of 205 other Mild Cognitive Impairment trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Mild Cognitive Impairment trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT04171323

Source: ClinicalTrials.gov NCT04171323, the US trial registry maintained by the National Library of Medicine. NCT04171323 (large enrollment · multi site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.