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NCT04171323 · ClinicalTrials.gov registry record · NA
The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
A NA study of Mild Cognitive Impairment and Dementia, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- NA
- Development phase
- 1,305
- Enrollment target
- 6
- Study locations
NCT04171323 is a NA study of Mild Cognitive Impairment and Dementia that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 1,305 participants, roughly in line with the 1,264-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target. The trial reports 6 study locations across 4 states.
The verdict
NCT04171323, a NA study of Mild Cognitive Impairment and Dementia, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- NA
- Development phase
- 1,305 participants
- Enrollment target
- 6
- Study locations
Study Summary
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination of CT exercises as compared to cognitive stimulation (which will serve as a stringent, active control) to modify the functional trajectories of older adults' with MCI, who are at high risk for dementia. The primary objective of the U01 phase was to design and pilot-test an adaptive, randomized clinical trial (RCT) of cognitive training (CT) combinations aimed to enhance performance of instrumental activities of daily living (IADL) among persons with mild cognitive impairment (MCI). In the R01 phase, the objective is to identify the best combination of CT exercises to delay dementia onset among persons with MCI. The longitudinal endpoint goal is reducing incident dementia. The primary aim of the study is to determine which CT combination has the best probability to delay dementia by producing the largest IADL improvements. The study further aims to explore neuroimaging and novel blood-based biomarkers.
Conditions Studied
Interventions
- BEHAVIORAL Cognitive Training
- BEHAVIORAL Computerized Cognitive Stimulation
Study Locations (6)
Florida
- University of Florida - Gainesville
- Active Mind Study - Tampa
South Carolina
- Clemson University - Greenville
- Clemson University - Seneca
California
- University of California San Francisco - San Francisco
Minnesota
- University of Minnesota - Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,305 participants |
| Start Date | 2020-03-03 |
| Est. Completion | 2028-08-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04171323
The ClinicalTrials.gov registry entry for NCT04171323 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 1,305 participants, a figure that helps gauge the scale of data the investigators plan to collect, roughly in line with the 1,264-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target. The listed sponsor is University of Alabama at Birmingham, which has 1,160 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Mild Cognitive Impairment appearing as the primary indexed condition, and to 2 interventions - of which Cognitive Training is the first listed.
NCT04171323 reports 6 study locations spanning 4 distinct geographic areas - top geographies include Florida, South Carolina, California.
Frequently Asked Questions
What is clinical trial NCT04171323 about?
NCT04171323 is a clinical study titled "The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia". Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination of CT exercises as compared to cognitive stimulati...
What is the current status of trial NCT04171323?
This trial is currently recruiting. It is a NA study. The enrollment target is 1,305 participants. The study started on 2020-03-03. Estimated completion is 2028-08-31.
What conditions does trial NCT04171323 study?
This clinical trial studies the following conditions: Mild Cognitive Impairment, Dementia, Age-related Cognitive Decline.
What interventions are being tested in trial NCT04171323?
The interventions under investigation include: Cognitive Training (BEHAVIORAL), Computerized Cognitive Stimulation (BEHAVIORAL).
Who is sponsoring clinical trial NCT04171323?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04171323 being conducted?
This trial has 6 study locations across California, Florida, Minnesota, South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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