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NCT05417555 · ClinicalTrials.gov registry record · NA

Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease

A NA study of Mild Cognitive Impairment and Deep Brain Stimulation, sponsored by University of California, Los Angeles.

Recruiting
Registry status
NA
Development phase
144
Enrollment target
1
Study location

NCT05417555: Recruiting NA study of Mild Cognitive Impairment and Deep Brain Stimulation, sponsored by University of California, Los Angeles.

NCT05417555 is a NA study of Mild Cognitive Impairment and Deep Brain Stimulation that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 144 participants, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05417555, a NA study of Mild Cognitive Impairment and Deep Brain Stimulation, is actively recruiting participants, sponsored by University of California, Los Angeles.

RECRUITING
Registry status
NA
Development phase
144 participants
Enrollment target
1
Study location

Study Summary

The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in people with Mild Cognitive Impairment and Mild Alzheimer's Disease. The main questions the study seeks to answer are: 1. Can LIFUP increase brain activity in the targeted area? 2. Can LIFUP improve memory in people with MCI and mild AD? 3. Can LIFUP improve connectivity of memory networks in the brain? Participants in this study will complete MRIs and memory testing, and receive Low Intensity Focused Ultrasound to a part of their brain involved in memory (the entorhinal cortex).

Primary Outcome

Perfusion ASL fMRI data will be collected before and after sonication. Analyses will assess the statistical relationship between ASL signal throughout the brain pre and post sonication.

Conditions Studied

Mild Cognitive Impairment Deep Brain Stimulation Mild Alzheimer's Disease Amnestic Mild Cognitive Disorder

Interventions

  • DEVICE Low-Intensity Focused Ultrasound Pulsation (LIFUP)

Study Locations (1)

California

  • UCLA Semel Institute for Neuroscience and Behavior - Los Angeles

Trial Details

FieldValue
Enrollment Target 144 participants
Start Date 2022-09-01
Est. Completion 2026-07-31
Phase NA
University of California, Los Angeles

897 total trials

What NCT05417555 shows while recruiting

NCT05417555 is an interventional study that assigns participants to a tested intervention. The registered 144 participants enrollment target is mid-sized for trials with a published cap, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (89% lower).

The record links to 4 conditions, with Mild Cognitive Impairment appearing as the primary indexed condition, and to 1 intervention - of which Low-Intensity Focused Ultrasound Pulsation (LIFUP) is the first listed.

NCT05417555 reports a single indexed study location in California.

Frequently Asked Questions

What is clinical trial NCT05417555 about?

NCT05417555 is a clinical study titled "Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease". The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in people with Mild Cognitive Impairment and Mild Alzheimer's Disease. The mai...

What is the current status of trial NCT05417555?

This trial is currently recruiting. It is a NA study. The enrollment target is 144 participants. The study started on 2022-09-01. Estimated completion is 2026-07-31.

What conditions does trial NCT05417555 study?

This clinical trial studies the following conditions: Mild Cognitive Impairment, Deep Brain Stimulation, Mild Alzheimer's Disease, Amnestic Mild Cognitive Disorder.

What interventions are being tested in trial NCT05417555?

The interventions under investigation include: Low-Intensity Focused Ultrasound Pulsation (LIFUP) (DEVICE).

Who is sponsoring clinical trial NCT05417555?

This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05417555 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Mild Cognitive Impairment

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05417555's enrollment target sits among peer trials

144 71st of 205 higher than 133 of 205 other Mild Cognitive Impairment trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Mild Cognitive Impairment trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT05417555

Source: ClinicalTrials.gov NCT05417555, the US trial registry maintained by the National Library of Medicine. NCT05417555 (mid enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.