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NCT05877196 · ClinicalTrials.gov registry record · NA
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
A NA study of Alzheimer Disease and Mild Cognitive Impairment, sponsored by Arizona State University.
- Recruiting
- Registry status
- NA
- Development phase
- 216
- Enrollment target
- 1
- Study location
NCT05877196: Recruiting NA study of Alzheimer Disease and Mild Cognitive Impairment, sponsored by Arizona State University.
NCT05877196 is a NA study of Alzheimer Disease and Mild Cognitive Impairment that is actively recruiting participants, run by Arizona State University. The registered enrollment target is 216 participants, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05877196, a NA study of Alzheimer Disease and Mild Cognitive Impairment, is actively recruiting participants, sponsored by Arizona State University.
- RECRUITING
- Registry status
- NA
- Development phase
- 216 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are: * test the effects of aerobic exercise on aerobic fitness, white matter hyperintensity (WMH) volume, and patient-centered outcomes; * identify the best exercise to improve aerobic fitness and reduce non-responses over 6 months; and * examines the mechanisms of aerobic exercise's action on memory in older adults with early AD. Participants will receive 6 months of supervised exercise, undergo cognitive data collection and exercise testing 5 times over a year span, have an MRI brain scan 3 times over a one-year span, and have monthly follow-up discussions on health and wellness.
Primary Outcome
VO2peak will be assessed from the symptom-limited peak cycle-ergometer test
Conditions Studied
Interventions
- BEHAVIORAL Moderate Intensity Continuous Training (MICT)
- BEHAVIORAL Chair-based Stretch
- BEHAVIORAL High-Intensity Interval Training (HIIT)
- BEHAVIORAL Combined Aerobic Resistance Exercise (CARE)
Study Locations (1)
Arizona
- Arizona State University - Phoenix
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 216 participants |
| Start Date | 2023-06-22 |
| Est. Completion | 2028-06-30 |
| Phase | NA |
What NCT05877196 shows while recruiting
NCT05877196 is an interventional study that assigns participants to a tested intervention. The registered 216 participants enrollment target is mid-sized for trials with a published cap, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (92% lower).
The record links to 6 conditions, with Alzheimer Disease appearing as the primary indexed condition, and to 4 interventions - of which Moderate Intensity Continuous Training (MICT) is the first listed.
NCT05877196 reports a single indexed study location in Arizona.
Frequently Asked Questions
What is clinical trial NCT05877196 about?
NCT05877196 is a clinical study titled "A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses". The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are: * test the effects of aerobic exercise on aerobic fitne...
What is the current status of trial NCT05877196?
This trial is currently recruiting. It is a NA study. The enrollment target is 216 participants. The study started on 2023-06-22. Estimated completion is 2028-06-30.
What conditions does trial NCT05877196 study?
This clinical trial studies the following conditions: Alzheimer Disease, Mild Cognitive Impairment, Cognitive Impairment, Cognitive Decline, Memory Impairment.
What interventions are being tested in trial NCT05877196?
The interventions under investigation include: Moderate Intensity Continuous Training (MICT) (BEHAVIORAL), Chair-based Stretch (BEHAVIORAL), High-Intensity Interval Training (HIIT) (BEHAVIORAL), Combined Aerobic Resistance Exercise (CARE) (BEHAVIORAL).
Who is sponsoring clinical trial NCT05877196?
This trial is sponsored by Arizona State University, which has 187 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05877196 being conducted?
This trial has 1 study location across Arizona. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05877196's enrollment target sits among peer trials
216 101st of 306 higher than 205 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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