Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Chronic Pain: early-phase trial registry
139 of 302 indexed Chronic Pain trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #29 of 28,707 conditions by registered trial count.
302 US clinical trials · 139 currently recruiting · #29 of 28,707 conditions by registered trial count
Chronic Pain: 302 US clinical trials tracked, 139 recruiting.
Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.
Enrollment posture brief
Registry condition chronic-pain
OPEN 139 | RECR 46% | LATE 15 | EARLY 41 | RANK #29 | SPON 16
Volume-matched condition peers
Nearest open-share peer: Recurrent Glioblastoma (46% recruiting · 63 trials)
Chronic Pain lists 139 open slots (46% of 302 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Chronic Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Chronic Pain is recruiting above its size-band peers.
139 of 302 indexed trials (46%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Chronic Pain trials is spread across many organizations.
VA Office of Research and Development accounts for 16 of 302 trials (5.3%). 155 distinct sponsors appear on at least one study for this condition label.
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Typical Chronic Pain enrolment sits around 80 participants.
Median target enrolment is 80 among the 302 trials that report a genuine target (sentinel values excluded). 164 of those (54.3%) plan for fewer than 100 participants.
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Chronic Pain research is mostly interventional.
260 interventional and 42 observational studies make up this index (86.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
302 total, page 2 of 7
Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain
Washington University School of Medicine
NCT07270406
Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma
University of Florida
NCT05561595
CBT-CP for Veterans With SMI
VA Office of Research and Development
NCT06758414
IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs
Albert Einstein College of Medicine
NCT05492825
From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects
Massachusetts General Hospital
NCT05661903
Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain
University of South Florida
NCT06345872
Randomized Trial of ACT and a Care Management App in Primary Care-based Buprenorphine Treatment
Albert Einstein College of Medicine
NCT05039554
RCT of a Weighted Blanket to Reduce Pain in Veterans With Chronic Pain
VA Office of Research and Development
NCT05963607
Mind Body Syndrome Therapy for Chronic Pain
Beth Israel Deaconess Medical Center
NCT04689646
Divided or Single Exposure (DOSE) Study
University of Maryland, Baltimore
NCT05459402
Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis
University of Pittsburgh
NCT04996628
PREVAIL Interdisciplinary Track: A Pragmatic Randomized Clinical Trial
Salem Veterans Affairs Medical Center
NCT06427356
Combined THC and CBD for OUD and Chronic Pain
Yale University
NCT06544291
Neuromodulation + Prolonged Exposure Therapy: Evaluation of a Technology-Enhanced, Integrated Treatment for Pain and PTSD
The University of Texas Health Science Center, Houston
NCT07116109
Neuroimaging of Opioid Phase (OPAL)
Duke University
NCT05905419
Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain
Duke University
NCT06983678
Optimization of NIBS for Treatment of Addiction
Case Western Reserve University
NCT04379115
Prospective Assessment of Integrative Therapies for Neuromusculoskeletal Pain (PAIN)
David Moss
NCT07094282
Utilizing Battlefield Acupuncture to Treat Chronic Pain
Edith Nourse Rogers Memorial Veterans Hospital
NCT06128772
Pain Reduction Using NEurostimulation Study
Weill Medical College of Cornell University
NCT05311956
The PROACTIVE Study for Black Elders
University of Florida
NCT06512727
VCOM Pain Free Research Collaborative
Edward Via Virginia College of Osteopathic Medicine
NCT06533345
Brief Mindfulness-Oriented Recovery Enhancement vs Brief Cognitive-Behavioral Therapy for Chronic Pain
Florida State University
NCT07207174
Placebo Impacts Sleep and Pain Modulation in Chronic Pain
University of Maryland, Baltimore
NCT06225817
Virtual 1-Session Spanish "Empowered Relief" Group Intervention for Chronic Pain
Stanford University
NCT04546685
Can Medical Cannabis Affect Opioid Use?
Thomas Jefferson University
NCT06206252
Evaluating the Acceptability, Feasibility and Usability of Various Conversational Data Collection Software
AugMend Health
NCT07336537
Examining the Effectiveness of Asynchronous Versus Synchronous Yoga for Veterans With Chronic Pain
Portland VA Medical Center
NCT06973876
Improving Sleep in Veterans With the Polytrauma Clinical Triad
VA Office of Research and Development
NCT06477796
Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome
Spaulding Rehabilitation Hospital
NCT04206215
Brain Connectivity Patterns in Chronic Temporomandibular Joint Disorders
University of Minnesota
NCT05068908
NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow
The Cleveland Clinic
NCT06373978
Palmitoylethanolamide for Chronic Inflammatory Pain Conditions
Navy Medical Center San Diego
NCT06273462
Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure
Florida State University
NCT06471075
A Community Health Worker-Led Program for Chronic Pain and Loneliness in Older Adults
University of Michigan
NCT06671925
Dronabinol as an Adjunct for Reducing Pain
Christopher D. Verri
NCT06454669
Pilot Study: Impact of Biomarker-Guided Dietary Supplementation on Quality-of-Life Measures in Subjects With Chronic Pain
Ethos Research & Development
NCT06247813
Haloperidol for Pain Control in Patients With Acute Musculoskeletal Back Pain in the Emergency Department
Western Michigan University School of Medicine
NCT06395428
Predictors of Pain in Sickle Cell Disease
Duke University
NCT06139510
Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control
Boston Scientific Corporation
NCT07190807
Enhanced Recovery After Major Surgery and Chronic Pain for Total Knee Arthroplasty
Hospital for Special Surgery, New York
NCT05981105
Opioids, Low Nicotine Cigarettes, and Chronic Pain
Duke University
NCT06747871
CIH Stepped Care for Co-occurring Chronic Pain and PTSD
University of Washington
NCT06219408
E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app
University of Iowa
NCT07032350
Group Integrative Breathwork for Chronic Pain
University of Florida
NCT06977984
Opioid Adherence and Support Through Innovative Texting Strategies
University of New Mexi
NCT07350148
Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study
Massachusetts General Hospital
NCT07118722
Comparing the Effects of Yoga Nidra to Yoga Nidra With Pain Acceptance Intention and Motor Imagery on Pain Outcomes
University of Central Florida
NCT06590181
Pain and Major Depressive Disorder
University of California, Los Angeles
NCT04556890
Using Ecological Momentary Assessment to Develop an Adaptive Psychological Intervention for Young Adults With Chronic Pain
Seattle Children's Hospital
NCT06932432
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 22 |
| Phase 3 | 7 |
| Phase 4 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on Chronic Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Chronic Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Chronic Pain page
302 registered trials, 139 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 139 Chronic Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Chronic Pain trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Chronic Pain condition card totals 302 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.