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ClinicalTrials.gov 139 recruiting now official registry

Chronic Pain clinical trials

139 of 302 indexed Chronic Pain trials are currently recruiting.

302 US clinical trials · 139 currently recruiting

Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.

The research picture

Chronic Pain has 302 registered US clinical trials, 139 of them open to new participants right now, about 46% of the total.

139
recruiting participants now
46%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
16
top sponsor: VA Office of Research and Development
Phase 119Phase 222Phase 37Phase 48

Active & Recent Trials

302 total, page 2 of 7

RECRUITING NA 200 participants

Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain

Washington University School of Medicine

NCT07270406

RECRUITING NA 195 participants

Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma

University of Florida

NCT05561595

RECRUITING NA 190 participants

CBT-CP for Veterans With SMI

VA Office of Research and Development

NCT06758414

RECRUITING NA 180 participants

IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs

Albert Einstein College of Medicine

NCT05492825

RECRUITING Phase 2 180 participants

From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects

Massachusetts General Hospital

NCT05661903

RECRUITING NA 165 participants

Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain

University of South Florida

NCT06345872

RECRUITING NA 160 participants

Randomized Trial of ACT and a Care Management App in Primary Care-based Buprenorphine Treatment

Albert Einstein College of Medicine

NCT05039554

RECRUITING NA 160 participants

RCT of a Weighted Blanket to Reduce Pain in Veterans With Chronic Pain

VA Office of Research and Development

NCT05963607

RECRUITING NA 150 participants

Mind Body Syndrome Therapy for Chronic Pain

Beth Israel Deaconess Medical Center

NCT04689646

RECRUITING Phase 2 150 participants

Divided or Single Exposure (DOSE) Study

University of Maryland, Baltimore

NCT05459402

RECRUITING NA 150 participants

Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

University of Pittsburgh

NCT04996628

RECRUITING NA 150 participants

PREVAIL Interdisciplinary Track: A Pragmatic Randomized Clinical Trial

Salem Veterans Affairs Medical Center

NCT06427356

RECRUITING Phase 2 147 participants

Combined THC and CBD for OUD and Chronic Pain

Yale University

NCT06544291

RECRUITING NA 146 participants

Neuromodulation + Prolonged Exposure Therapy: Evaluation of a Technology-Enhanced, Integrated Treatment for Pain and PTSD

The University of Texas Health Science Center, Houston

NCT07116109

RECRUITING NA 140 participants

Neuroimaging of Opioid Phase (OPAL)

Duke University

NCT05905419

RECRUITING NA 132 participants

Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain

Duke University

NCT06983678

RECRUITING NA 126 participants

Optimization of NIBS for Treatment of Addiction

Case Western Reserve University

NCT04379115

RECRUITING NA 125 participants

Prospective Assessment of Integrative Therapies for Neuromusculoskeletal Pain (PAIN)

David Moss

NCT07094282

RECRUITING NA 125 participants

Utilizing Battlefield Acupuncture to Treat Chronic Pain

Edith Nourse Rogers Memorial Veterans Hospital

NCT06128772

RECRUITING NA 125 participants

Pain Reduction Using NEurostimulation Study

Weill Medical College of Cornell University

NCT05311956

RECRUITING NA 120 participants

The PROACTIVE Study for Black Elders

University of Florida

NCT06512727

RECRUITING NA 120 participants

VCOM Pain Free Research Collaborative

Edward Via Virginia College of Osteopathic Medicine

NCT06533345

RECRUITING NA 120 participants

Brief Mindfulness-Oriented Recovery Enhancement vs Brief Cognitive-Behavioral Therapy for Chronic Pain

Florida State University

NCT07207174

RECRUITING NA 111 participants

Placebo Impacts Sleep and Pain Modulation in Chronic Pain

University of Maryland, Baltimore

NCT06225817

RECRUITING NA 110 participants

Virtual 1-Session Spanish "Empowered Relief" Group Intervention for Chronic Pain

Stanford University

NCT04546685

RECRUITING 110 participants

Can Medical Cannabis Affect Opioid Use?

Thomas Jefferson University

NCT06206252

RECRUITING NA 100 participants

Evaluating the Acceptability, Feasibility and Usability of Various Conversational Data Collection Software

AugMend Health

NCT07336537

RECRUITING NA 100 participants

Examining the Effectiveness of Asynchronous Versus Synchronous Yoga for Veterans With Chronic Pain

Portland VA Medical Center

NCT06973876

RECRUITING NA 96 participants

Improving Sleep in Veterans With the Polytrauma Clinical Triad

VA Office of Research and Development

NCT06477796

RECRUITING NA 95 participants

Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome

Spaulding Rehabilitation Hospital

NCT04206215

RECRUITING 95 participants

Brain Connectivity Patterns in Chronic Temporomandibular Joint Disorders

University of Minnesota

NCT05068908

RECRUITING Phase 4 92 participants

NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow

The Cleveland Clinic

NCT06373978

RECRUITING Phase 2 80 participants

Palmitoylethanolamide for Chronic Inflammatory Pain Conditions

Navy Medical Center San Diego

NCT06273462

RECRUITING NA 80 participants

Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure

Florida State University

NCT06471075

RECRUITING NA 80 participants

A Community Health Worker-Led Program for Chronic Pain and Loneliness in Older Adults

University of Michigan

NCT06671925

RECRUITING Phase 2 75 participants

Dronabinol as an Adjunct for Reducing Pain

Christopher D. Verri

NCT06454669

RECRUITING Phase 2 75 participants

Pilot Study: Impact of Biomarker-Guided Dietary Supplementation on Quality-of-Life Measures in Subjects With Chronic Pain

Ethos Research & Development

NCT06247813

RECRUITING Phase 4 75 participants

Haloperidol for Pain Control in Patients With Acute Musculoskeletal Back Pain in the Emergency Department

Western Michigan University School of Medicine

NCT06395428

RECRUITING NA 70 participants

Predictors of Pain in Sickle Cell Disease

Duke University

NCT06139510

RECRUITING NA 70 participants

Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control

Boston Scientific Corporation

NCT07190807

RECRUITING NA 64 participants

Enhanced Recovery After Major Surgery and Chronic Pain for Total Knee Arthroplasty

Hospital for Special Surgery, New York

NCT05981105

RECRUITING NA 60 participants

Opioids, Low Nicotine Cigarettes, and Chronic Pain

Duke University

NCT06747871

RECRUITING NA 60 participants

CIH Stepped Care for Co-occurring Chronic Pain and PTSD

University of Washington

NCT06219408

RECRUITING NA 60 participants

E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app

University of Iowa

NCT07032350

RECRUITING NA 60 participants

Group Integrative Breathwork for Chronic Pain

University of Florida

NCT06977984

RECRUITING NA 60 participants

Opioid Adherence and Support Through Innovative Texting Strategies

University of New Mexi

NCT07350148

RECRUITING NA 60 participants

Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study

Massachusetts General Hospital

NCT07118722

RECRUITING NA 60 participants

Comparing the Effects of Yoga Nidra to Yoga Nidra With Pain Acceptance Intention and Motor Imagery on Pain Outcomes

University of Central Florida

NCT06590181

RECRUITING NA 54 participants

Pain and Major Depressive Disorder

University of California, Los Angeles

NCT04556890

RECRUITING 50 participants

Using Ecological Momentary Assessment to Develop an Adaptive Psychological Intervention for Young Adults With Chronic Pain

Seattle Children's Hospital

NCT06932432

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Phase Distribution

PhaseTrial count
Phase 1 19
Phase 2 22
Phase 3 7
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Pain Trial Landscape

302 indexed Chronic Pain studies · 139 recruiting (46%).

Phase mix: 15 late (III/IV) vs 41 early (I/II).

Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Pain?

PlainTrial tracks 302 US clinical trials for Chronic Pain, of which 139 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Pain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.