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HIV clinical trials
109 of 304 indexed HIV trials are currently recruiting.
304 US clinical trials · 109 currently recruiting
HIV is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 24 of these trials.
The research picture
HIV has 304 registered US clinical trials, 109 of them open to new participants right now, about 36% of the total.
- 109
- recruiting participants now
- 36%
- of trials open to enrollment
- 25
- in Phase 3–4 (later-stage)
- 24
- top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active & Recent Trials
304 total, page 1 of 7
Five Point Initiative: A Bundled Implementation Strategy to Address the HIV Epidemic in Black Communities
University of Miami
NCT06062342
The DC Cohort Longitudinal HIV Status Neutral Study
George Washington University
NCT01206920
Effectiveness of Relationship Education for Reducing HIV Incidence Among SGM
Northwestern University
NCT05678556
HOTSPOT Study: Implement and Evaluate the PrEP (Pre-exposure Prophylaxis) Implementation Strategy
University of Texas Southwestern Medical Center
NCT06919419
Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00114647
ACCESS: Accelerating Cervical Cancer Elimination Through the Integration of Screen-and-treat Services
University of California, San Diego
NCT06128304
Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001281
Collection of Blood for Multiple Collaborative Studies
University of California, San Francisco
NCT01336855
Peru Decentralized HIV Care
Yale University
NCT05910268
Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer
National Cancer Institute (NCI)
NCT00006518
Ending the HIV Epidemic for Patient and Healthcare Staff Well-being
Columbia University
NCT05785169
Leukapheresis Procedures to Obtain Plasma and Lymphocytes for Research Studies on Antiretroviral Naive HIV-1 Research Participants
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00039689
Finishing HIV Project
University of Miami
NCT06406049
Clinical and Immunologic Monitoring of Patients With Known or Suspected HIV Infection
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00789009
#ChopViolence/#ChopHIV
Hektoen Institute for Medical Research
NCT04769492
Gathering Online for Dialogue and Discussion to Enhance Social Support
RTI International
NCT05753683
Leukapheresis to Obtain Plasma or Lymphocytes for Studies of HIV-infected Patients, Including Long-term Non-progressors
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00029445
PrEP Readiness Interventions for Sustained Motivation (PRISM)
Florida International University
NCT06637436
HIV Prevention Intervention for Latino Male Couples
University of Central Florida
NCT06131931
Viral Load in Blood and Lymph Tissues in People Living With HIV
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001316
Multidisciplinary Low-Barrier and Mobile HIV Care to Improve Retention and Viral Suppression: Stakeholder-Engaged Design and Evaluation
University of California, San Francisco
NCT05887557
Trial of a Harm Reduction Strategy for People With HIV Who Smoke Cigarettes
Montefiore Medical Center
NCT05642715
Telehealth for Pain and Unhealthy Drinking Among PLWH
Boston University
NCT05503173
Behavioral Activation and Risk Reduction for Stimulant Use Among Sexually Active Adolescents and Young Adults
Westat
NCT06444360
Effectiveness and Implementation of Text Messaging to Improve HIV Testing in Adolescents
Northwestern University
NCT06096519
Alcohol and "Heat of the Moment" Sexual Decision Making
Boston University Charles River Campus
NCT05729256
Testing Two Interventions to Improve Health Outcomes and Quality of Life Among Rural Older Adults Living With HIV
Medical College of Wisconsin
NCT06269081
J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations
University of Chicago
NCT06477588
A Remotely Delivered Tai Chi/Qigong Intervention for Older People Living With HIV
Florida International University
NCT06586619
Telemedicine for Unhealthy Alcohol Use in Persons Living With HIV Using CETA
University of Alabama at Birmingham
NCT04955795
Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care
Johns Hopkins University
NCT05241990
PRIDE III Prison Interventions and HIV Prevention Collaboration
Yale University
NCT06962033
The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
University of Miami
NCT05453513
The Collaborative Care PrTNER Study
Children's Hospital of Philadelphia
NCT06585631
Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies ...
National Cancer Institute (NCI)
NCT05470491
Text Education About Cardiovascular Health and HIV (TEACH-HIV)
University of California, San Francisco
NCT05642858
Mitigating the Impact of Stigma and Shame Among People Living With HIV and Substance Use Disorders
Boston University
NCT05934305
Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP
University of Connecticut
NCT05669534
Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women
Yale University
NCT05547048
Striving Towards EmPowerment and Medication Adherence R01
University of Miami
NCT06463886
Joining Under-connected Networks to Optimize "Salud" (Health) ("JUNTOS")
University of Miami
NCT06432725
Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma
University of Oklahoma
NCT05208671
Optimizing Tobacco Treatment Delivery for People Living With HIV
Medical University of South Carolina
NCT05019495
Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury
Wake Forest University Health Sciences
NCT04810858
Prevention Ambassadors: Intervention to Promote HIV Service Engagement in the Networks of SSP Clients
San Diego State University
NCT06848686
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
Icahn School of Medicine at Mount Sinai
NCT04353778
Transitional Housing and HIV Health
University of Pennsylvania
NCT06829394
Skeletal Muscle Energetics and Fatiguability in Older Individuals
Johns Hopkins University
NCT04142047
Wellness Intervention for Smoking and HIV
University of Arizona
NCT04725617
A Study of VRC07-523LS, PGT121.414.LS, and PGDM1400LS Broadly Neutralizing Monoclonal Antibodies Given Intravenously in Adult Participants Without HIV
National Institute of Allergy and Infectious Diseases (NIAID)
NCT06812494
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 32 |
| Phase 2 | 32 |
| Phase 3 | 12 |
| Phase 4 | 13 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the HIV Trial Landscape
304 indexed HIV studies · 109 recruiting (36%).
Phase mix: 25 late (III/IV) vs 64 early (I/II).
Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (24 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for HIV?
PlainTrial tracks 304 US clinical trials for HIV, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for HIV?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.