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ClinicalTrials.gov 109 recruiting now official registry

HIV clinical trials

109 of 304 indexed HIV trials are currently recruiting.

304 US clinical trials · 109 currently recruiting

HIV is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 24 of these trials.

The research picture

HIV has 304 registered US clinical trials, 109 of them open to new participants right now, about 36% of the total.

109
recruiting participants now
36%
of trials open to enrollment
25
in Phase 3–4 (later-stage)
24
top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Phase 132Phase 232Phase 312Phase 413

Active & Recent Trials

304 total, page 1 of 7

RECRUITING NA 20,400 participants

Five Point Initiative: A Bundled Implementation Strategy to Address the HIV Epidemic in Black Communities

University of Miami

NCT06062342

RECRUITING 19,000 participants

The DC Cohort Longitudinal HIV Status Neutral Study

George Washington University

NCT01206920

RECRUITING NA 5,000 participants

Effectiveness of Relationship Education for Reducing HIV Incidence Among SGM

Northwestern University

NCT05678556

RECRUITING NA 3,600 participants

HOTSPOT Study: Implement and Evaluate the PrEP (Pre-exposure Prophylaxis) Implementation Strategy

University of Texas Southwestern Medical Center

NCT06919419

RECRUITING 3,000 participants

Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00114647

RECRUITING NA 2,436 participants

ACCESS: Accelerating Cervical Cancer Elimination Through the Integration of Screen-and-treat Services

University of California, San Diego

NCT06128304

RECRUITING 2,419 participants

Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00001281

RECRUITING 2,000 participants

Collection of Blood for Multiple Collaborative Studies

University of California, San Francisco

NCT01336855

RECRUITING NA 1,450 participants

Peru Decentralized HIV Care

Yale University

NCT05910268

RECRUITING 1,029 participants

Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer

National Cancer Institute (NCI)

NCT00006518

RECRUITING NA 1,000 participants

Ending the HIV Epidemic for Patient and Healthcare Staff Well-being

Columbia University

NCT05785169

RECRUITING 750 participants

Leukapheresis Procedures to Obtain Plasma and Lymphocytes for Research Studies on Antiretroviral Naive HIV-1 Research Participants

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00039689

RECRUITING NA 624 participants

Finishing HIV Project

University of Miami

NCT06406049

RECRUITING 600 participants

Clinical and Immunologic Monitoring of Patients With Known or Suspected HIV Infection

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00789009

RECRUITING NA 525 participants

#ChopViolence/#ChopHIV

Hektoen Institute for Medical Research

NCT04769492

RECRUITING NA 500 participants

Gathering Online for Dialogue and Discussion to Enhance Social Support

RTI International

NCT05753683

RECRUITING 400 participants

Leukapheresis to Obtain Plasma or Lymphocytes for Studies of HIV-infected Patients, Including Long-term Non-progressors

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00029445

RECRUITING NA 400 participants

PrEP Readiness Interventions for Sustained Motivation (PRISM)

Florida International University

NCT06637436

RECRUITING NA 400 participants

HIV Prevention Intervention for Latino Male Couples

University of Central Florida

NCT06131931

RECRUITING 400 participants

Viral Load in Blood and Lymph Tissues in People Living With HIV

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00001316

RECRUITING NA 400 participants

Multidisciplinary Low-Barrier and Mobile HIV Care to Improve Retention and Viral Suppression: Stakeholder-Engaged Design and Evaluation

University of California, San Francisco

NCT05887557

RECRUITING NA 400 participants

Trial of a Harm Reduction Strategy for People With HIV Who Smoke Cigarettes

Montefiore Medical Center

NCT05642715

RECRUITING NA 385 participants

Telehealth for Pain and Unhealthy Drinking Among PLWH

Boston University

NCT05503173

RECRUITING NA 360 participants

Behavioral Activation and Risk Reduction for Stimulant Use Among Sexually Active Adolescents and Young Adults

Westat

NCT06444360

RECRUITING NA 360 participants

Effectiveness and Implementation of Text Messaging to Improve HIV Testing in Adolescents

Northwestern University

NCT06096519

RECRUITING NA 354 participants

Alcohol and "Heat of the Moment" Sexual Decision Making

Boston University Charles River Campus

NCT05729256

RECRUITING NA 352 participants

Testing Two Interventions to Improve Health Outcomes and Quality of Life Among Rural Older Adults Living With HIV

Medical College of Wisconsin

NCT06269081

RECRUITING NA 350 participants

J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations

University of Chicago

NCT06477588

RECRUITING NA 326 participants

A Remotely Delivered Tai Chi/Qigong Intervention for Older People Living With HIV

Florida International University

NCT06586619

RECRUITING NA 308 participants

Telemedicine for Unhealthy Alcohol Use in Persons Living With HIV Using CETA

University of Alabama at Birmingham

NCT04955795

RECRUITING NA 300 participants

Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care

Johns Hopkins University

NCT05241990

RECRUITING NA 300 participants

PRIDE III Prison Interventions and HIV Prevention Collaboration

Yale University

NCT06962033

RECRUITING NA 280 participants

The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV

University of Miami

NCT05453513

RECRUITING NA 275 participants

The Collaborative Care PrTNER Study

Children's Hospital of Philadelphia

NCT06585631

RECRUITING Phase 1 265 participants

Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies ...

National Cancer Institute (NCI)

NCT05470491

RECRUITING NA 260 participants

Text Education About Cardiovascular Health and HIV (TEACH-HIV)

University of California, San Francisco

NCT05642858

RECRUITING NA 256 participants

Mitigating the Impact of Stigma and Shame Among People Living With HIV and Substance Use Disorders

Boston University

NCT05934305

RECRUITING Phase 4 256 participants

Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

University of Connecticut

NCT05669534

RECRUITING Phase 4 250 participants

Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women

Yale University

NCT05547048

RECRUITING NA 250 participants

Striving Towards EmPowerment and Medication Adherence R01

University of Miami

NCT06463886

RECRUITING NA 245 participants

Joining Under-connected Networks to Optimize "Salud" (Health) ("JUNTOS")

University of Miami

NCT06432725

RECRUITING NA 234 participants

Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma

University of Oklahoma

NCT05208671

RECRUITING NA 231 participants

Optimizing Tobacco Treatment Delivery for People Living With HIV

Medical University of South Carolina

NCT05019495

RECRUITING NA 220 participants

Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

Wake Forest University Health Sciences

NCT04810858

RECRUITING NA 210 participants

Prevention Ambassadors: Intervention to Promote HIV Service Engagement in the Networks of SSP Clients

San Diego State University

NCT06848686

RECRUITING Phase 1 207 participants

Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV

Icahn School of Medicine at Mount Sinai

NCT04353778

RECRUITING 200 participants

Transitional Housing and HIV Health

University of Pennsylvania

NCT06829394

RECRUITING 200 participants

Skeletal Muscle Energetics and Fatiguability in Older Individuals

Johns Hopkins University

NCT04142047

RECRUITING NA 200 participants

Wellness Intervention for Smoking and HIV

University of Arizona

NCT04725617

RECRUITING Phase 2 200 participants

A Study of VRC07-523LS, PGT121.414.LS, and PGDM1400LS Broadly Neutralizing Monoclonal Antibodies Given Intravenously in Adult Participants Without HIV

National Institute of Allergy and Infectious Diseases (NIAID)

NCT06812494

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Phase Distribution

PhaseTrial count
Phase 1 32
Phase 2 32
Phase 3 12
Phase 4 13

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the HIV Trial Landscape

304 indexed HIV studies · 109 recruiting (36%).

Phase mix: 25 late (III/IV) vs 64 early (I/II).

Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (24 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for HIV?

PlainTrial tracks 304 US clinical trials for HIV, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for HIV?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.