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ClinicalTrials.gov 139 recruiting now official registry

Chronic Pain clinical trials

139 of 302 indexed Chronic Pain trials are currently recruiting.

302 US clinical trials · 139 currently recruiting

Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.

The research picture

Chronic Pain has 302 registered US clinical trials, 139 of them open to new participants right now, about 46% of the total.

139
recruiting participants now
46%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
16
top sponsor: VA Office of Research and Development
Phase 119Phase 222Phase 37Phase 48

Active & Recent Trials

302 total, page 1 of 7

RECRUITING 50,000 participants

RIVER At Home Ketamine Protocols

RIVER Foundation

NCT06070766

RECRUITING 50,000 participants

A DirEct to PatieNt Study in Chronic Pain

Boston Scientific Corporation

NCT05515341

RECRUITING 15,000 participants

Patient Retrospective Outcomes (PRO)

Boston Scientific Corporation

NCT01550575

RECRUITING 5,000 participants

A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children

Telethon Kids Institute

NCT06354699

RECRUITING 2,000 participants

Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator

Abbott Medical Devices

NCT03876054

RECRUITING NA 1,188 participants

Impact of 4PCP on Practitioner and Patient Outcomes

Virginia Commonwealth University

NCT05580419

RECRUITING NA 1,000 participants

Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain

Washington University School of Medicine

NCT06978166

RECRUITING 1,000 participants

Embo Registry; National Registry for Artery Embolization

Vascular Solutions of North Carolina

NCT06477965

RECRUITING 800 participants

Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

Brown University

NCT05754190

RECRUITING NA 716 participants

Chronic Pain Management In Primary Care Using Behavioral Health Consultants

The University of Texas Health Science Center at San Antonio

NCT04680000

RECRUITING Phase 3 608 participants

Tele-Collaborative Outreach to Rural Patients With Chronic Pain

Oregon Health and Science University

NCT06091202

RECRUITING NA 586 participants

Integrating Nonpharmacologic Strategies for Pain With Inclusion, Respect, and Equity

University of California, San Francisco

NCT06183281

RECRUITING 500 participants

AIMS Medical Outcomes Study

Advanced Integrative Medical Science Institute

NCT04512755

RECRUITING 500 participants

Targeted Realtime Assessment of Chronic Pain in Youth

Stanford University

NCT06867757

RECRUITING Phase 3 500 participants

Nonpharmacologic Pain Management in FQHC Primary Care Clinics

University of Utah

NCT04923334

RECRUITING 500 participants

Ketamine Treatment Plans for Chronic Conditions

RIVER Foundation

NCT06038409

RECRUITING NA 500 participants

QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing

Anna Evans Phillips

NCT03434392

RECRUITING NA 468 participants

MIVetsCan: Can-Coach Trial (Phase 2)

University of Michigan

NCT06283862

RECRUITING NA 460 participants

Moderators and Mediators (M & M Trial) of Psychosocial Treatments of Chronic Pain

Rush University Medical Center

NCT06044649

RECRUITING Phase 4 450 participants

Stanford Pragmatic Effectiveness Comparison

Stanford University

NCT04441034

RECRUITING NA 432 participants

Pain Management Teams Using Whole Health to Optimize Function and Safety in Veterans: The TEAMWORK Trial

VA Office of Research and Development

NCT07149870

RECRUITING 420 participants

Overlapping Pain Trajectory Study

Children's Hospital Medical Center, Cincinnati

NCT05752396

RECRUITING NA 400 participants

Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention

Florida State University

NCT07335159

RECRUITING NA 400 participants

Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline

Massachusetts General Hospital

NCT06246929

RECRUITING NA 385 participants

Telehealth for Pain and Unhealthy Drinking Among PLWH

Boston University

NCT05503173

RECRUITING NA 376 participants

Partners4Pain & Wellbeing: A Randomized Trial of Community Supported Complementary and Integrative Health Self-management for Back Pain

University of Minnesota

NCT06696352

RECRUITING Phase 3 375 participants

CARES-Spine (Comprehensive Analgesic, Recovery, and Education Support for Spine Surgery) Trial

Stanford University

NCT06027099

RECRUITING NA 360 participants

Group-based Integrative Pain Management in Primary Care Safety Net Clinics

University of California, San Francisco

NCT06327542

RECRUITING NA 345 participants

Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset

Rush University Medical Center

NCT05700279

RECRUITING NA 340 participants

HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain

Rhode Island Hospital

NCT06931158

RECRUITING NA 304 participants

Equipping Patients Using Interventions for Pain and Depression

Indiana University

NCT06500780

RECRUITING NA 300 participants

Under-Resourced Adults With Chronic Pain eHealth Study

Mayo Clinic

NCT06688864

RECRUITING 300 participants

Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy

Hugo W. Moser Research Institute at Kennedy Krieger

NCT05197946

RECRUITING Phase 3 300 participants

Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits

University of Utah

NCT06387290

RECRUITING 300 participants

Individual Differences in Gait and Osteoarthritis Pain

University of Pittsburgh

NCT07308873

RECRUITING Phase 4 294 participants

Better Options for Chronic Cancer Pain

VA Office of Research and Development

NCT06574009

RECRUITING NA 274 participants

Online Yoga vs Acceptance and Commitment Therapy for Treating Chronic Musculoskeletal Pain

Palo Alto Veterans Institute for Research

NCT06704061

RECRUITING NA 240 participants

Assessing the Efficacy of an Acceptance-Based Digital Intervention for Veterans With Chronic Pain

VA Office of Research and Development

NCT06058624

RECRUITING Phase 1 240 participants

ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain

Medical University of South Carolina

NCT06442566

RECRUITING NA 240 participants

EPPIC: Easing Pelvic Pain Interventions Clinical Research Program

State University of New York at Buffalo

NCT05127616

RECRUITING 240 participants

Examining Racial and Socioeconomic Differences in Chronic Low Back Pain

Washington University School of Medicine

NCT05991440

RECRUITING NA 228 participants

Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer: A Randomized Clinical Trial

St. Jude Children's Research Hospital

NCT07160621

RECRUITING NA 225 participants

Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial

University of New Mexi

NCT06565416

RECRUITING Phase 2 220 participants

Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain (CBOT-P)

Evon Medics

NCT06671132

RECRUITING NA 212 participants

Our Whole Lives Gemini: Virtual Integrative Medical Group Visits for Managing Chronic Pain

Cambridge Health Alliance

NCT06515925

RECRUITING NA 204 participants

Stepped Care for Patients to Optimize Whole Recovery

Yale University

NCT05155163

RECRUITING NA 204 participants

Pain Self-Management and Treatment Engagement for Patients Taking Opioids

University of Pittsburgh

NCT06855732

RECRUITING Phase 2 200 participants

A Mobile Intervention to Reduce Pain and Improve Health-III

Wake Forest University

NCT06623669

RECRUITING NA 200 participants

Virtual Reality Treatment for Adults With Chronic Back Pain (VRNT)

CognifiSense

NCT07033195

RECRUITING NA 200 participants

Improving Health for Older Adults With Pain Through Engagement

Massachusetts General Hospital

NCT06119698

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Phase Distribution

PhaseTrial count
Phase 1 19
Phase 2 22
Phase 3 7
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Pain Trial Landscape

302 indexed Chronic Pain studies · 139 recruiting (46%).

Phase mix: 15 late (III/IV) vs 41 early (I/II).

Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Pain?

PlainTrial tracks 302 US clinical trials for Chronic Pain, of which 139 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Pain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.