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ClinicalTrials.gov 29 recruiting now official registry

Recurrent Glioblastoma clinical trials

Every US clinical trial registered for Recurrent Glioblastoma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

63 US clinical trials · 29 currently recruiting

The research picture

Recurrent Glioblastoma has 63 registered US clinical trials, 29 of them open to new participants right now — about 46% of the total.

29
recruiting participants now
46%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
7
top sponsor: National Cancer Institute (NCI)

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 464 participants

The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)

Jasper Gerritsen

NCT06283927

RECRUITING 225 participants

The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma

Erasmus Medical Center

NCT06273176

RECRUITING Phase 2 184 participants

Anti-Lag-3 (Relatlimab) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma

National Cancer Institute (NCI)

NCT06325683

RECRUITING Phase 2 134 participants

Retifanlimab with Bevacizumab and Hypofractionated Radiotherapy for the Treatment of Recurrent Glioblastoma

Academic and Community Cancer Research United

NCT06160206

RECRUITING NA 96 participants

Spectroscopic MRI, Proton Therapy, and Avastin for Recurrent Glioblastoma

University of Miami

NCT05284643

RECRUITING Phase 2 80 participants

A Multicenter Trial to Identify Optimal Atezolizumab Biomarkers in the Setting of Recurrent Glioblastoma. The MOAB Trial

Duke University

NCT06069726

RECRUITING Phase 2 78 participants

Surgical Pembro +/- Olaparib w TMZ for rGBM

L. Nicolas Gonzalez Castro, MD, PhD

NCT05463848

RECRUITING Phase 1 60 participants

IL13Ra2-CAR T Cells With or Without Nivolumab and Ipilimumab in Treating Patients With GBM

City of Hope Medical Center

NCT04003649

RECRUITING NA 50 participants

Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma

Jonsson Comprehensive Cancer Center

NCT06090903

RECRUITING Phase 1 48 participants

RMC-5552 Monotherapy in Adult Subjects With Recurrent Glioblastoma

Nicholas Butowski

NCT05557292

RECRUITING Phase 1 36 participants

MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

M.D. Anderson Cancer Center

NCT03896568

RECRUITING Phase 1 36 participants

A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM

Boston Scientific Corporation

NCT05303467

RECRUITING Phase 2 32 participants

Sacituzumab Govitecan in Recurrent Glioblastoma

The University of Texas Health Science Center at San Antonio

NCT04559230

RECRUITING Phase 2 30 participants

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

Memorial Sloan Kettering Cancer Center

NCT06058988

RECRUITING Phase 1 28 participants

Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

National Cancer Institute (NCI)

NCT06344130

RECRUITING Phase 1 27 participants

Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

City of Hope Medical Center

NCT06815029

RECRUITING Early Phase 1 27 participants

A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

Ugonma Chukwueke

NCT06552260

RECRUITING Phase 1 24 participants

Verteporfin for the Treatment of Recurrent High Grade EGFR-Mutated Glioblastoma

Emory University

NCT04590664

RECRUITING Phase 1 21 participants

CARv3-TEAM-E T Cells in Glioblastoma

Marcela V. Maus, M.D.,Ph.D.

NCT05660369

RECRUITING Phase 2 20 participants

OPTIMUS PRIME: Safety and Feasibility of OPTune GIO® Integrated With MRI-gUided Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa, A randomizEd Trial

University of Florida

NCT06558214

RECRUITING Phase 1 20 participants

Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

Sabine Mueller, MD, PhD

NCT04323046

RECRUITING Phase 1 20 participants

Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells

Hideho Okada, MD, PhD

NCT06186401

RECRUITING Phase 1 18 participants

CUE-102 in Recurrent Glioblastoma

David Reardon, MD

NCT06917885

RECRUITING Early Phase 1 15 participants

Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma

Abramson Cancer Center at Penn Medicine

NCT06613841

RECRUITING Phase 1 12 participants

Different Approaches for CART-EGFR-IL13Ra2 Dosing in Recurrent GBM

University of Pennsylvania

NCT07209241

RECRUITING Phase 1 11 participants

Sonodynamic Therapy in Patients With Recurrent GBM

Shayan Moosa, MD

NCT06039709

RECRUITING NA 10 participants

A Study to Assess the Feasibility and Safety of Intratumoral Diffusing Alpha Emitters for the Treatment of Recurrent Glioblastoma

Alpha Tau Medical

NCT06910306

RECRUITING Early Phase 1 8 participants

Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma

Mayo Clinic

NCT07076472

RECRUITING Phase 1 6 participants

Atezolizumab and Cabozantinib for the Treatment of Recurrent Glioblastoma

M.D. Anderson Cancer Center

NCT05039281

ACTIVE NOT RECRUITING Phase 3 560 participants

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

CarThera

NCT05902169

ACTIVE NOT RECRUITING NA 146 participants

DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma

ECOG-ACRIN Cancer Research Group

NCT03115333

ACTIVE NOT RECRUITING Phase 1 78 participants

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

University of California, San Francis

NCT03749187

ACTIVE NOT RECRUITING Phase 2 70 participants

Cediranib Maleate and Olaparib Compared to Bevacizumab in Treating Patients With Recurrent Glioblastoma

National Cancer Institute (NCI)

NCT02974621

ACTIVE NOT RECRUITING Phase 1 68 participants

Mycophenolate Mofetil Combined With Radiation Therapy in Glioblastoma

University of Michigan Rogel Cancer Center

NCT04477200

ACTIVE NOT RECRUITING Phase 1 65 participants

Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma

City of Hope Medical Center

NCT02208362

ACTIVE NOT RECRUITING Phase 1 60 participants

Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma

Northwestern University

NCT05236036

ACTIVE NOT RECRUITING Phase 2 59 participants

Testing the Addition of the Immune Therapy Drugs, Tocilizumab and Atezolizumab, to Radiation Therapy for Recurrent Glioblastoma

National Cancer Institute (NCI)

NCT04729959

ACTIVE NOT RECRUITING Phase 1 57 participants

Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma

Northwestern University

NCT04528680

ACTIVE NOT RECRUITING Phase 2 48 participants

Clindamycin and Triamcinolone in People With Glioblastoma to Prevent Skin-Related Side Effects of Tumor Treating Fields

Memorial Sloan Kettering Cancer Center

NCT04469075

ACTIVE NOT RECRUITING Phase 1 40 participants

Pembrolizumab and a Vaccine (ATL-DC) for the Treatment of Surgically Accessible Recurrent Glioblastoma

Jonsson Comprehensive Cancer Center

NCT04201873

ACTIVE NOT RECRUITING Phase 1 34 participants

Lonafarnib and Temozolomide in Treating Patients with Glioblastoma Multiforme That is Recurrent or Did Not Respond to Previous Treatment with Temozolomide

M.D. Anderson Cancer Center

NCT00102648

ACTIVE NOT RECRUITING Early Phase 1 30 participants

Fimepinostat in Treating Brain Tumors in Children and Young Adults

Sabine Mueller, MD, PhD

NCT03893487

ACTIVE NOT RECRUITING Phase 2 30 participants

Niraparib/TTFields in GBM

Abramson Cancer Center at Penn Medicine

NCT04221503

ACTIVE NOT RECRUITING Phase 1 24 participants

RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)

University of Florida

NCT06389591

ACTIVE NOT RECRUITING Phase 1 19 participants

Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the Treatment of MMP2+ Recurrent or Progressive Glioblastoma

City of Hope Medical Center

NCT04214392

ACTIVE NOT RECRUITING Phase 1 18 participants

Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas

City of Hope Medical Center

NCT02192359

ACTIVE NOT RECRUITING Phase 2 18 participants

Pembrolizumab in Treating Patients With Recurrent Glioblastoma

M.D. Anderson Cancer Center

NCT02337686

ACTIVE NOT RECRUITING Early Phase 1 14 participants

Identification of Treatment Concentrations of Defactinib or VS-6766 for the Treatment of Patients With Glioblastoma

Emory University

NCT05798507

ACTIVE NOT RECRUITING Early Phase 1 4 participants

Natural Progesterone for the Treatment of Recurrent Glioblastoma

Emory University

NCT05091866

COMPLETED Phase 3 423 participants

Cediranib in Combination With Lomustine Chemotherapy in Recurrent Glioblastoma

AstraZeneca

NCT00777153

COMPLETED Phase 2 137 participants

Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors

National Cancer Institute (NCI)

NCT01609790

COMPLETED Phase 2 127 participants

A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma

Celldex Therapeutics

NCT01498328

COMPLETED Phase 1 74 participants

Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma

National Cancer Institute (NCI)

NCT01849146

COMPLETED Phase 1 67 participants

BGB-290 and Temozolomide in Treating Patients With Recurrent Gliomas With IDH1/2 Mutations

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03914742

COMPLETED Phase 2 36 participants

Tremelimumab and Durvalumab in Combination or Alone in Treating Patients With Recurrent Malignant Glioma

Northwestern University

NCT02794883

COMPLETED Phase 1 30 participants

Feasibility of Individualized Therapy for Recurrent Glioblastoma

Jennifer Clarke

NCT03681028

COMPLETED Phase 1 29 participants

Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

National Cancer Institute (NCI)

NCT02101905

COMPLETED Phase 2 25 participants

LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma

Istari Oncology

NCT04479241

COMPLETED Phase 1 14 participants

ASP8374 + Cemiplimab in Recurrent Glioma

Dana-Farber Cancer Institute

NCT04826393

COMPLETED Phase 2 14 participants

Regorafenib in Bevacizumab Refractory Recurrent Glioblastoma

Case Comprehensive Cancer Center

NCT04051606

COMPLETED NA 14 participants

Mathematical Model-Adapted Radiation In Glioblastoma

Dana-Farber Cancer Institute

NCT03557372

COMPLETED Phase 1 12 participants

BPM31510 in Treating Patients With Recurrent High-Grade Glioma Previously Treated With Bevacizumab

Seema Nagpal

NCT03020602

COMPLETED Phase 1 8 participants

STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Brain

M.D. Anderson Cancer Center

NCT01904123

Phase Distribution

PhaseTrial count
Phase 1 37
Phase 2 17
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Recurrent Glioblastoma Trial Landscape

ClinicalTrials.gov lists 63 US studies indexed under Recurrent Glioblastoma, and 29 of those are currently open to recruitment — roughly 46% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Recurrent Glioblastoma shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 54 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Recurrent Glioblastoma is led by National Cancer Institute (NCI) with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 63 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Recurrent Glioblastoma?

PlainTrial tracks 63 US clinical trials for Recurrent Glioblastoma, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Recurrent Glioblastoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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