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ClinicalTrials.gov 56 recruiting now official registry

COVID-19 clinical trials

56 of 204 indexed COVID-19 trials are currently recruiting.

204 US clinical trials · 56 currently recruiting

COVID-19 is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 56 of them currently open to new participants. 30 are in Phase 3-4 (later-stage) and 60 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 15 of these trials.

The research picture

COVID-19 has 204 registered US clinical trials, 56 of them open to new participants right now, about 27% of the total.

56
recruiting participants now
27%
of trials open to enrollment
30
in Phase 3–4 (later-stage)
15
top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Phase 118Phase 242Phase 321Phase 49

Active & Recent Trials

204 total, page 1 of 5

RECRUITING NA 37,122 participants

Addressing Vaccine Acceptance in Carceral Settings Through Community Engagement

Yale University

NCT05796505

RECRUITING Phase 3 25,500 participants

A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age

BioNTech SE

NCT07300839

RECRUITING 25,000 participants

Preparedness Through Respiratory Virus Epidemiology and Community Engagement

University of California, San Diego

NCT07147517

RECRUITING 20,000 participants

Respiratory Virus Sampling and Repository

National Institute of Allergy and Infectious Diseases (NIAID)

NCT05266222

RECRUITING 10,000 participants

Influenza & COVID-19 Obstetric and Perinatal Epidemiology Study in India

Boston University

NCT06168019

RECRUITING Phase 2 4,292 participants

A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Children

BioNTech SE

NCT05543616

RECRUITING NA 1,500 participants

The SINCERE Intervention to Address COVID-19 Health Disparities

Andrea Wallace

NCT05228886

RECRUITING NA 1,400 participants

Dime La VerDAD: Verify, Debunk, and Disseminate

University of Chicago

NCT06417762

RECRUITING 1,200 participants

Vaccine Responses to SARS-CoV-2 and Other Emerging Infectious Diseases

National Institute of Allergy and Infectious Diseases (NIAID)

NCT05078905

RECRUITING NA 1,000 participants

Clinical Validation of the Aptitude Medical Systems Metrix COVID-19 Test

Aptitude Medical Systems

NCT06744660

RECRUITING 1,000 participants

Viral Infections in Healthy and Immunocompromised Hosts

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01306084

RECRUITING 1,000 participants

CU-COMMITS: COVID-19 Care in Black and Latino Communities and Households. Clinical and Molecular Outcomes of SARS-CoV-2

Columbia University

NCT05467930

RECRUITING NA 1,000 participants

A Multi-Site Clinical Evaluation of the LIAISON NES FLU A/B, RSV & COVID-19 Assay in Symptomatic Patients

DiaSorin Molecular

NCT06672692

RECRUITING 1,000 participants

ARMOR Study: COVID-19 Seroprevalence Among Healthcare Workers

Columbia University

NCT04367857

RECRUITING NA 900 participants

Connecting Friends and Health Workers to Boost COVID-19 Vaccination in Latino Communities

Johns Hopkins University

NCT06128928

RECRUITING Phase 4 832 participants

A Study to Evaluate the Immunogenicity and Safety of mRNA-1283 COVID-19 Variant-containing Formulations

ModernaTX

NCT07089706

RECRUITING 800 participants

Determinants of SARS (Severe Acute Respiratory Syndrome)-COV2 (COVID-19) Persistence After Convalescence

Columbia University

NCT04448145

RECRUITING 600 participants

COVID-19 Outcome Prediction Algorithm

University of California, Los Angeles

NCT05471011

RECRUITING Phase 3 550 participants

Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID

Wes Ely

NCT06631287

RECRUITING 510 participants

Cardiac Magnetic Resonance Tissue Characterization in COVID-19 Survivors

Weill Medical College of Cornell University

NCT05164744

RECRUITING 500 participants

Methodist Health System COVID-19 Patient Registry

Methodist Health System

NCT04477889

RECRUITING 400 participants

Dysbiosis & Long COVID

University of Chicago

NCT06825819

RECRUITING 350 participants

NIH RECOVER Tissue Pathology: Understanding the Long-Term Impact of COVID-19

NYU Langone Health

NCT05292274

RECRUITING 300 participants

The Impact of COVID-19 on Maternal and Neonatal Outcomes

Johns Hopkins University

NCT05197621

RECRUITING Phase 4 280 participants

A Pilot Clinical Evaluation of Astepro® Nasal Spray for Management of Early SARS-CoV-2 Infection

University of Chicago

NCT06008860

RECRUITING Phase 3 274 participants

Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

Ansun Biopharma

NCT03808922

RECRUITING 250 participants

A Study to Explore the Role of Gut Flora in COVID-19 Infection

ProgenaBiome

NCT04359836

RECRUITING NA 240 participants

Impact of Aerosol Box Use During Cardiopulmonary Arrest: A Multicenter Study

KidSIM Simulation Program

NCT05868239

RECRUITING Phase 2 200 participants

Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults

CastleVax

NCT07215520

RECRUITING 180 participants

COVID-19 Coagulopathy Extension Study

University of Iowa

NCT05334615

RECRUITING Phase 1 165 participants

Positron Emission Tomography (PET) Imaging of Thrombosis

Massachusetts General Hospital

NCT03830320

RECRUITING Phase 3 160 participants

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

Pfizer

NCT05261139

RECRUITING NA 150 participants

Vale+Tú Salud: Corner-Based Trial to Test a Latino Day Laborer Program Adapted to Prevent COVID-19

The University of Texas Health Science Center, Houston

NCT06821113

RECRUITING 150 participants

Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04794829

RECRUITING 150 participants

Neural and Cognitive Consequences of COVID-19 Survival

San Francisco Veterans Affairs Medical Center

NCT06208943

RECRUITING Phase 1 140 participants

A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes

National Institute of Allergy and Infectious Diseases (NIAID)

NCT07221162

RECRUITING NA 125 participants

Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)

Children's Hospital of Orange County

NCT04978571

RECRUITING NA 120 participants

REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19

Duke University

NCT05218083

RECRUITING Phase 2 112 participants

Mitoquinone/Mitoquinol Mesylate as Oral and Safe Postexposure Prophylaxis for Covid-19

University of Texas Southwestern Medical Center

NCT05886816

RECRUITING 100 participants

COVID-19 Health Adjustments in Nutrition, General Wellness, and Exercise

Indiana University

NCT07128095

RECRUITING 100 participants

Passive Detection- SARS-CoV-2 (COVID-19) A&M Breathalyzer (PROTECT Kiosk) for Operational Medicine

The Geneva Foundation

NCT06402318

RECRUITING Phase 1 80 participants

A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses

Kara Chew

NCT06810934

RECRUITING Phase 1 80 participants

A Study Evaluating MDX2301 in Healthy Adults and Adults at Higher Risk for Severe COVID-19.

ModeX Therapeutics, An OPKO Health Company

NCT07445971

RECRUITING 75 participants

A Study of Post COVID-19 Mechanisms for Chronic Lung Sequelae

Mayo Clinic

NCT06006884

RECRUITING NA 70 participants

Music Mindfulness Study 2a.

Yale University

NCT06505226

RECRUITING 60 participants

The Measurement of Chemicals in Exhaled Breath Can Identify If a Person is Infected with COVID-19

N5 Sensors

NCT06571136

RECRUITING Phase 4 54 participants

Comparative Immunogenicity of Respiratory Virus Vaccines (CIRV2) Study

Henry M. Jackson Foundation for the Advancement of Military Medicine

NCT07287137

RECRUITING 50 participants

Impact of the Coronavirus (COVID-19) on Patients With Cancer

Stanford University

NCT04330521

RECRUITING Phase 4 50 participants

Impact of Immunosuppression Adjustment on COVID-19 Vaccination Response in Kidney Transplant Recipients

University of California, Davis

NCT05060991

RECRUITING Phase 2 50 participants

Convalescent Plasma as a Possible Treatment for COVID-19

University of Illinois at Chicago

NCT04442191

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Phase Distribution

PhaseTrial count
Phase 1 18
Phase 2 42
Phase 3 21
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the COVID-19 Trial Landscape

204 indexed COVID-19 studies · 56 recruiting (27%).

Phase mix: 30 late (III/IV) vs 60 early (I/II).

Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (15 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for COVID-19?

PlainTrial tracks 204 US clinical trials for COVID-19, of which 56 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for COVID-19?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.