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COVID-19 clinical trials
56 of 204 indexed COVID-19 trials are currently recruiting.
204 US clinical trials · 56 currently recruiting
COVID-19 is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 56 of them currently open to new participants. 30 are in Phase 3-4 (later-stage) and 60 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 15 of these trials.
The research picture
COVID-19 has 204 registered US clinical trials, 56 of them open to new participants right now, about 27% of the total.
- 56
- recruiting participants now
- 27%
- of trials open to enrollment
- 30
- in Phase 3–4 (later-stage)
- 15
- top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active & Recent Trials
204 total, page 1 of 5
Addressing Vaccine Acceptance in Carceral Settings Through Community Engagement
Yale University
NCT05796505
A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age
BioNTech SE
NCT07300839
Preparedness Through Respiratory Virus Epidemiology and Community Engagement
University of California, San Diego
NCT07147517
Respiratory Virus Sampling and Repository
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05266222
Influenza & COVID-19 Obstetric and Perinatal Epidemiology Study in India
Boston University
NCT06168019
A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Children
BioNTech SE
NCT05543616
The SINCERE Intervention to Address COVID-19 Health Disparities
Andrea Wallace
NCT05228886
Dime La VerDAD: Verify, Debunk, and Disseminate
University of Chicago
NCT06417762
Vaccine Responses to SARS-CoV-2 and Other Emerging Infectious Diseases
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05078905
Clinical Validation of the Aptitude Medical Systems Metrix COVID-19 Test
Aptitude Medical Systems
NCT06744660
Viral Infections in Healthy and Immunocompromised Hosts
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01306084
CU-COMMITS: COVID-19 Care in Black and Latino Communities and Households. Clinical and Molecular Outcomes of SARS-CoV-2
Columbia University
NCT05467930
A Multi-Site Clinical Evaluation of the LIAISON NES FLU A/B, RSV & COVID-19 Assay in Symptomatic Patients
DiaSorin Molecular
NCT06672692
ARMOR Study: COVID-19 Seroprevalence Among Healthcare Workers
Columbia University
NCT04367857
Connecting Friends and Health Workers to Boost COVID-19 Vaccination in Latino Communities
Johns Hopkins University
NCT06128928
A Study to Evaluate the Immunogenicity and Safety of mRNA-1283 COVID-19 Variant-containing Formulations
ModernaTX
NCT07089706
Determinants of SARS (Severe Acute Respiratory Syndrome)-COV2 (COVID-19) Persistence After Convalescence
Columbia University
NCT04448145
COVID-19 Outcome Prediction Algorithm
University of California, Los Angeles
NCT05471011
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
Wes Ely
NCT06631287
Cardiac Magnetic Resonance Tissue Characterization in COVID-19 Survivors
Weill Medical College of Cornell University
NCT05164744
Methodist Health System COVID-19 Patient Registry
Methodist Health System
NCT04477889
Dysbiosis & Long COVID
University of Chicago
NCT06825819
NIH RECOVER Tissue Pathology: Understanding the Long-Term Impact of COVID-19
NYU Langone Health
NCT05292274
The Impact of COVID-19 on Maternal and Neonatal Outcomes
Johns Hopkins University
NCT05197621
A Pilot Clinical Evaluation of Astepro® Nasal Spray for Management of Early SARS-CoV-2 Infection
University of Chicago
NCT06008860
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
Ansun Biopharma
NCT03808922
A Study to Explore the Role of Gut Flora in COVID-19 Infection
ProgenaBiome
NCT04359836
Impact of Aerosol Box Use During Cardiopulmonary Arrest: A Multicenter Study
KidSIM Simulation Program
NCT05868239
Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults
CastleVax
NCT07215520
COVID-19 Coagulopathy Extension Study
University of Iowa
NCT05334615
Positron Emission Tomography (PET) Imaging of Thrombosis
Massachusetts General Hospital
NCT03830320
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
Pfizer
NCT05261139
Vale+Tú Salud: Corner-Based Trial to Test a Latino Day Laborer Program Adapted to Prevent COVID-19
The University of Texas Health Science Center, Houston
NCT06821113
Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04794829
Neural and Cognitive Consequences of COVID-19 Survival
San Francisco Veterans Affairs Medical Center
NCT06208943
A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes
National Institute of Allergy and Infectious Diseases (NIAID)
NCT07221162
Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)
Children's Hospital of Orange County
NCT04978571
REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19
Duke University
NCT05218083
Mitoquinone/Mitoquinol Mesylate as Oral and Safe Postexposure Prophylaxis for Covid-19
University of Texas Southwestern Medical Center
NCT05886816
COVID-19 Health Adjustments in Nutrition, General Wellness, and Exercise
Indiana University
NCT07128095
Passive Detection- SARS-CoV-2 (COVID-19) A&M Breathalyzer (PROTECT Kiosk) for Operational Medicine
The Geneva Foundation
NCT06402318
A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses
Kara Chew
NCT06810934
A Study Evaluating MDX2301 in Healthy Adults and Adults at Higher Risk for Severe COVID-19.
ModeX Therapeutics, An OPKO Health Company
NCT07445971
A Study of Post COVID-19 Mechanisms for Chronic Lung Sequelae
Mayo Clinic
NCT06006884
Music Mindfulness Study 2a.
Yale University
NCT06505226
The Measurement of Chemicals in Exhaled Breath Can Identify If a Person is Infected with COVID-19
N5 Sensors
NCT06571136
Comparative Immunogenicity of Respiratory Virus Vaccines (CIRV2) Study
Henry M. Jackson Foundation for the Advancement of Military Medicine
NCT07287137
Impact of the Coronavirus (COVID-19) on Patients With Cancer
Stanford University
NCT04330521
Impact of Immunosuppression Adjustment on COVID-19 Vaccination Response in Kidney Transplant Recipients
University of California, Davis
NCT05060991
Convalescent Plasma as a Possible Treatment for COVID-19
University of Illinois at Chicago
NCT04442191
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 18 |
| Phase 2 | 42 |
| Phase 3 | 21 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the COVID-19 Trial Landscape
204 indexed COVID-19 studies · 56 recruiting (27%).
Phase mix: 30 late (III/IV) vs 60 early (I/II).
Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (15 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for COVID-19?
PlainTrial tracks 204 US clinical trials for COVID-19, of which 56 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for COVID-19?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.