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NCT06454669 · ClinicalTrials.gov registry record · Phase 2
Dronabinol as an Adjunct for Reducing Pain
A Phase 2 study of Chronic Pain and Low Back Pain, sponsored by Christopher D. Verri.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 75
- Enrollment target
- 1
- Study location
NCT06454669: Recruiting Phase 2 study of Chronic Pain and Low Back Pain, sponsored by Christopher D. Verri.
NCT06454669 is a Phase 2 study of Chronic Pain and Low Back Pain that is actively recruiting participants, run by Christopher D. Verri. The registered enrollment target is 75 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06454669, a Phase 2 study of Chronic Pain and Low Back Pain, is actively recruiting participants, sponsored by Christopher D. Verri.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 75 participants
- Enrollment target
- 1
- Study location
Study Summary
This exploratory, proof-of-concept study is a double-blind (participants and investigators will be blinded), placebo-controlled, randomized, two-arm clinical trial of Marinol \[dronabinol, synthetic Δ9-tetrahydrocannabinol (THC)\] for chronic low back pain (cLBP) with a 2:1 allocation ratio. Up to 75 subjects will be enrolled in this pilot study and randomized to receive doses of THC (up to 30 mg/day), orally, over 8 weeks. This study will be conducted at a single site; it does not include any stratifications, and there is no interim analysis planned. Notably, the goal is to determine whether there is enough evidence of the safety of THC to support the development of later-phase clinical trials. Thus, detailed developmental plans are contingent on the outcomes of this study.
Primary Outcome
For change in pain intensity from baseline to 8-weeks, the investigators will estimate the mean within each arm using the Research Standards for Chronic Low-Back Pain (RScLBP).
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Dronabinol
Study Locations (1)
Texas
- Michael E Debakey VA Medical Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2024-06-15 |
| Est. Completion | 2029-12-31 |
| Phase | Phase 2 |
What NCT06454669 shows while recruiting
NCT06454669 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (90% lower).
The record links to 3 conditions, with Chronic Pain appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06454669 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06454669 about?
NCT06454669 is a clinical study titled "Dronabinol as an Adjunct for Reducing Pain". This exploratory, proof-of-concept study is a double-blind (participants and investigators will be blinded), placebo-controlled, randomized, two-arm clinical trial of Marinol \[dronabinol, synthetic Δ9-tetrahydrocannabinol (THC)\] for chronic low back pain (cLBP) with a 2:1 allocation ratio. Up to 7...
What is the current status of trial NCT06454669?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 75 participants. The study started on 2024-06-15. Estimated completion is 2029-12-31.
What conditions does trial NCT06454669 study?
This clinical trial studies the following conditions: Chronic Pain, Low Back Pain, Back Injuries.
What interventions are being tested in trial NCT06454669?
The interventions under investigation include: Placebo (DRUG), Dronabinol (DRUG).
Who is sponsoring clinical trial NCT06454669?
This trial is sponsored by Christopher D. Verri, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06454669 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06454669's enrollment target sits among peer trials
75 159th of 301 higher than 140 of 301 other Chronic Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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