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Chronic Pain clinical trials
139 of 302 indexed Chronic Pain trials are currently recruiting.
302 US clinical trials · 139 currently recruiting
Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.
The research picture
Chronic Pain has 302 registered US clinical trials, 139 of them open to new participants right now, about 46% of the total.
- 139
- recruiting participants now
- 46%
- of trials open to enrollment
- 15
- in Phase 3–4 (later-stage)
- 16
- top sponsor: VA Office of Research and Development
Active & Recent Trials
302 total, page 3 of 7
Interoceptive Awareness and Function in Adolescents With Chronic Pain
Connecticut Children's Medical Center
NCT07325110
Chronic Non-Specific Neck Pain Treated With Tai Chi and Chiropractic Care
Harvard University Faculty of Medicine
NCT05726331
Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain
Medical University of South Carolina
NCT06205342
Developing an Opioid Taper Intervention Before Total Joint Arthroplasty
University of Alabama at Birmingham
NCT05788016
Mindfulness And Placebo for Pain (MAPP) Study
Arizona State University
NCT06720909
Novel Stimulation Patterns to Improve the Effectiveness of Spinal Cord Stimulation
Ashwin Viswanathan
NCT05968664
Managing Chronic Tendon Pain by Metformin
James Wang
NCT06100822
Scrambler Therapy in Chronic Pancreatitis
Johns Hopkins University
NCT07174609
Retrospective-Prospective PNS Study
Curonix
NCT06845631
Mind Body Intervention for Chronic Upper Extremity Pain (Repetitive Stress Injury)
Beth Israel Deaconess Medical Center
NCT06903962
Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis
VA Office of Research and Development
NCT05925036
Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity
Wake Forest University Health Sciences
NCT04427709
Cannabidiol in Opioid Use Disorder and Chronic Pain
Yale University
NCT04587791
One MORE for Chronic Pain in Latinos
University of Utah
NCT06316713
Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma
Johns Hopkins University
NCT05989230
Sana Device for Post-Treatment Lyme Disease Syndrome Chronic Pain
Icahn School of Medicine at Mount Sinai
NCT06655844
Effect of Music on Pain and Anxiety in Chronic Pain Patients Undergoing Lumbar Interventional Procedures.
Milton S. Hershey Medical Center
NCT04924244
Optimizing Accelerated TMS for Chronic Pain With Thompson Sampling
University of Minnesota
NCT07103135
Emotional Awareness and Expression Therapy for Chronic Pain and Opioid Use Disorder
University of Michigan
NCT06865560
Physical Activity Pain Resilience
William Black
NCT07049029
External Sensing and Neuromodulation to Assess Diabetic Pain Outcomes (XANADO)
Abbott Medical Devices
NCT05537662
Local Cerebral Oxygenation in Chronic Pain Patients Utilizing Spinal Cord Stimulation
CereVu Medical
NCT06559735
Low-Intensity Focused Ultrasound and the Complex Patient
Virginia Polytechnic Institute and State University
NCT06297200
PAIN: a Project Assessing the Impact of a Novel Cannabinoid Product
Staci Gruber, Ph.D.
NCT03984565
The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature
Faith A. Richardson
NCT05067998
Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans
University of Illinois at Chicago
NCT05094297
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
Indiana University
NCT05603702
Mindfulness-Based Intervention for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease
University of Illinois at Chicago
NCT07402811
Integrated PTSD and Chronic Pain Treatment
Weill Medical College of Cornell University
NCT07225049
The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain
University of Minnesota
NCT05741788
SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease
University of Nebraska
NCT06480786
Improving Spinal Cord Stimulation With ECAPS
University of Minnesota
NCT04938245
Insula Neuromodulation for Chronic Neuropathic Pain
University of Virginia
NCT05404581
Group Medical Visits and Chiropractic Care for Older Adults With Chronic Spine Pain
Brigham and Women's Hospital
NCT06632535
The Role of Brain Dopamine in Chronic Pain
University of Rochester
NCT05285683
VR Mindfulness Training for Veterans With SCI
VA Office of Research and Development
NCT06587607
Mind Body Intervention for Chronic Migraine Headaches
Beth Israel Deaconess Medical Center
NCT06690060
Mindfulness-Based Ecological Momentary Intervention for Opioid Use Disorder and Chronic Pain
Arizona State University
NCT06947122
A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy
University of Chicago
NCT06382272
SMART Stepped Care Management for Low Back Pain in the Military Health System
Brooke Army Medical Center
NCT04172038
A Trial of a Positive Psychology Intervention for Older Adults (RESET)
University of Michigan
NCT05451589
Use of Driving Tests to Evaluate Patient Performance on Oral Opioids
Asokumar Buvanendran
NCT00659035
Adapting and Implementing a Nurse Care Management Model to Care for Rural Patients With Chronic Pain
University of Washington
NCT06407115
STEPS: An Efficacy Trial of a Chronic Pain Self-Management Program for Older Adults
University of Michigan
NCT05278234
PEACE: Comparing Chronic Pain Treatment Options
Memorial Sloan Kettering Cancer Center
NCT02979574
Matching Adults to Treatments for Chronic Pain (MATCH) Study
University of Washington
NCT05699252
HFIT Versus TENS Study for Chronic Low Back and Knee Pain
Hinge Health
NCT05821530
Pharmacogenomics Applied to Chronic Pain Treatment in Primary Care
Medstar Health Research Institute
NCT04685304
Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment
Erin Winstanley
NCT06367387
Non-pharmacological Treatment for Pain After Spine Surgery
Dan Rhon
NCT04770480
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 22 |
| Phase 3 | 7 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Chronic Pain Trial Landscape
302 indexed Chronic Pain studies · 139 recruiting (46%).
Phase mix: 15 late (III/IV) vs 41 early (I/II).
Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Chronic Pain?
PlainTrial tracks 302 US clinical trials for Chronic Pain, of which 139 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Chronic Pain?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.