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ClinicalTrials.gov 139 recruiting now official registry

Chronic Pain clinical trials

139 of 302 indexed Chronic Pain trials are currently recruiting.

302 US clinical trials · 139 currently recruiting

Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.

The research picture

Chronic Pain has 302 registered US clinical trials, 139 of them open to new participants right now, about 46% of the total.

139
recruiting participants now
46%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
16
top sponsor: VA Office of Research and Development
Phase 119Phase 222Phase 37Phase 48

Active & Recent Trials

302 total, page 3 of 7

RECRUITING 49 participants

Interoceptive Awareness and Function in Adolescents With Chronic Pain

Connecticut Children's Medical Center

NCT07325110

RECRUITING NA 48 participants

Chronic Non-Specific Neck Pain Treated With Tai Chi and Chiropractic Care

Harvard University Faculty of Medicine

NCT05726331

RECRUITING Early Phase 1 48 participants

Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain

Medical University of South Carolina

NCT06205342

RECRUITING NA 45 participants

Developing an Opioid Taper Intervention Before Total Joint Arthroplasty

University of Alabama at Birmingham

NCT05788016

RECRUITING NA 45 participants

Mindfulness And Placebo for Pain (MAPP) Study

Arizona State University

NCT06720909

RECRUITING NA 43 participants

Novel Stimulation Patterns to Improve the Effectiveness of Spinal Cord Stimulation

Ashwin Viswanathan

NCT05968664

RECRUITING Phase 1 40 participants

Managing Chronic Tendon Pain by Metformin

James Wang

NCT06100822

RECRUITING NA 40 participants

Scrambler Therapy in Chronic Pancreatitis

Johns Hopkins University

NCT07174609

RECRUITING NA 40 participants

Retrospective-Prospective PNS Study

Curonix

NCT06845631

RECRUITING NA 40 participants

Mind Body Intervention for Chronic Upper Extremity Pain (Repetitive Stress Injury)

Beth Israel Deaconess Medical Center

NCT06903962

RECRUITING Phase 1 40 participants

Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis

VA Office of Research and Development

NCT05925036

RECRUITING Phase 2 38 participants

Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity

Wake Forest University Health Sciences

NCT04427709

RECRUITING Early Phase 1 34 participants

Cannabidiol in Opioid Use Disorder and Chronic Pain

Yale University

NCT04587791

RECRUITING NA 34 participants

One MORE for Chronic Pain in Latinos

University of Utah

NCT06316713

RECRUITING NA 30 participants

Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma

Johns Hopkins University

NCT05989230

RECRUITING NA 30 participants

Sana Device for Post-Treatment Lyme Disease Syndrome Chronic Pain

Icahn School of Medicine at Mount Sinai

NCT06655844

RECRUITING NA 30 participants

Effect of Music on Pain and Anxiety in Chronic Pain Patients Undergoing Lumbar Interventional Procedures.

Milton S. Hershey Medical Center

NCT04924244

RECRUITING Phase 1 30 participants

Optimizing Accelerated TMS for Chronic Pain With Thompson Sampling

University of Minnesota

NCT07103135

RECRUITING NA 30 participants

Emotional Awareness and Expression Therapy for Chronic Pain and Opioid Use Disorder

University of Michigan

NCT06865560

RECRUITING NA 30 participants

Physical Activity Pain Resilience

William Black

NCT07049029

RECRUITING NA 30 participants

External Sensing and Neuromodulation to Assess Diabetic Pain Outcomes (XANADO)

Abbott Medical Devices

NCT05537662

RECRUITING NA 25 participants

Local Cerebral Oxygenation in Chronic Pain Patients Utilizing Spinal Cord Stimulation

CereVu Medical

NCT06559735

RECRUITING NA 25 participants

Low-Intensity Focused Ultrasound and the Complex Patient

Virginia Polytechnic Institute and State University

NCT06297200

RECRUITING Phase 2 25 participants

PAIN: a Project Assessing the Impact of a Novel Cannabinoid Product

Staci Gruber, Ph.D.

NCT03984565

RECRUITING 25 participants

The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature

Faith A. Richardson

NCT05067998

RECRUITING NA 25 participants

Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans

University of Illinois at Chicago

NCT05094297

RECRUITING Phase 1 24 participants

STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis

Indiana University

NCT05603702

RECRUITING NA 20 participants

Mindfulness-Based Intervention for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease

University of Illinois at Chicago

NCT07402811

RECRUITING NA 20 participants

Integrated PTSD and Chronic Pain Treatment

Weill Medical College of Cornell University

NCT07225049

RECRUITING NA 15 participants

The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain

University of Minnesota

NCT05741788

RECRUITING NA 15 participants

SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease

University of Nebraska

NCT06480786

RECRUITING 15 participants

Improving Spinal Cord Stimulation With ECAPS

University of Minnesota

NCT04938245

RECRUITING NA 12 participants

Insula Neuromodulation for Chronic Neuropathic Pain

University of Virginia

NCT05404581

RECRUITING NA 10 participants

Group Medical Visits and Chiropractic Care for Older Adults With Chronic Spine Pain

Brigham and Women's Hospital

NCT06632535

RECRUITING Phase 2 10 participants

The Role of Brain Dopamine in Chronic Pain

University of Rochester

NCT05285683

RECRUITING NA 10 participants

VR Mindfulness Training for Veterans With SCI

VA Office of Research and Development

NCT06587607

RECRUITING NA 10 participants

Mind Body Intervention for Chronic Migraine Headaches

Beth Israel Deaconess Medical Center

NCT06690060

RECRUITING NA 10 participants

Mindfulness-Based Ecological Momentary Intervention for Opioid Use Disorder and Chronic Pain

Arizona State University

NCT06947122

RECRUITING NA 8 participants

A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy

University of Chicago

NCT06382272

ACTIVE NOT RECRUITING NA 850 participants

SMART Stepped Care Management for Low Back Pain in the Military Health System

Brooke Army Medical Center

NCT04172038

ACTIVE NOT RECRUITING NA 456 participants

A Trial of a Positive Psychology Intervention for Older Adults (RESET)

University of Michigan

NCT05451589

ACTIVE NOT RECRUITING 450 participants

Use of Driving Tests to Evaluate Patient Performance on Oral Opioids

Asokumar Buvanendran

NCT00659035

ACTIVE NOT RECRUITING NA 450 participants

Adapting and Implementing a Nurse Care Management Model to Care for Rural Patients With Chronic Pain

University of Washington

NCT06407115

ACTIVE NOT RECRUITING NA 414 participants

STEPS: An Efficacy Trial of a Chronic Pain Self-Management Program for Older Adults

University of Michigan

NCT05278234

ACTIVE NOT RECRUITING NA 360 participants

PEACE: Comparing Chronic Pain Treatment Options

Memorial Sloan Kettering Cancer Center

NCT02979574

ACTIVE NOT RECRUITING NA 331 participants

Matching Adults to Treatments for Chronic Pain (MATCH) Study

University of Washington

NCT05699252

ACTIVE NOT RECRUITING NA 325 participants

HFIT Versus TENS Study for Chronic Low Back and Knee Pain

Hinge Health

NCT05821530

ACTIVE NOT RECRUITING NA 315 participants

Pharmacogenomics Applied to Chronic Pain Treatment in Primary Care

Medstar Health Research Institute

NCT04685304

ACTIVE NOT RECRUITING Phase 4 268 participants

Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment

Erin Winstanley

NCT06367387

ACTIVE NOT RECRUITING NA 267 participants

Non-pharmacological Treatment for Pain After Spine Surgery

Dan Rhon

NCT04770480

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Phase Distribution

PhaseTrial count
Phase 1 19
Phase 2 22
Phase 3 7
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Pain Trial Landscape

302 indexed Chronic Pain studies · 139 recruiting (46%).

Phase mix: 15 late (III/IV) vs 41 early (I/II).

Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Pain?

PlainTrial tracks 302 US clinical trials for Chronic Pain, of which 139 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Pain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.