Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Chronic Pain: early-phase trial registry
139 of 302 indexed Chronic Pain trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #29 of 28,707 conditions by registered trial count.
302 US clinical trials · 139 currently recruiting · #29 of 28,707 conditions by registered trial count
Chronic Pain: 302 US clinical trials tracked, 139 recruiting.
Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.
Enrollment posture brief
Registry condition chronic-pain
OPEN 139 | RECR 46% | LATE 15 | EARLY 41 | RANK #29 | SPON 16
Volume-matched condition peers
Nearest open-share peer: Recurrent Glioblastoma (46% recruiting · 63 trials)
Chronic Pain lists 139 open slots (46% of 302 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Chronic Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Chronic Pain is recruiting above its size-band peers.
139 of 302 indexed trials (46%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Chronic Pain trials is spread across many organizations.
VA Office of Research and Development accounts for 16 of 302 trials (5.3%). 155 distinct sponsors appear on at least one study for this condition label.
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Typical Chronic Pain enrolment sits around 80 participants.
Median target enrolment is 80 among the 302 trials that report a genuine target (sentinel values excluded). 164 of those (54.3%) plan for fewer than 100 participants.
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Chronic Pain research is mostly interventional.
260 interventional and 42 observational studies make up this index (86.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
302 total, page 3 of 7
Interoceptive Awareness and Function in Adolescents With Chronic Pain
Connecticut Children's Medical Center
NCT07325110
Chronic Non-Specific Neck Pain Treated With Tai Chi and Chiropractic Care
Harvard University Faculty of Medicine
NCT05726331
Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain
Medical University of South Carolina
NCT06205342
Developing an Opioid Taper Intervention Before Total Joint Arthroplasty
University of Alabama at Birmingham
NCT05788016
Mindfulness And Placebo for Pain (MAPP) Study
Arizona State University
NCT06720909
Novel Stimulation Patterns to Improve the Effectiveness of Spinal Cord Stimulation
Ashwin Viswanathan
NCT05968664
Managing Chronic Tendon Pain by Metformin
James Wang
NCT06100822
Scrambler Therapy in Chronic Pancreatitis
Johns Hopkins University
NCT07174609
Retrospective-Prospective PNS Study
Curonix
NCT06845631
Mind Body Intervention for Chronic Upper Extremity Pain (Repetitive Stress Injury)
Beth Israel Deaconess Medical Center
NCT06903962
Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis
VA Office of Research and Development
NCT05925036
Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity
Wake Forest University Health Sciences
NCT04427709
Cannabidiol in Opioid Use Disorder and Chronic Pain
Yale University
NCT04587791
One MORE for Chronic Pain in Latinos
University of Utah
NCT06316713
Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma
Johns Hopkins University
NCT05989230
Sana Device for Post-Treatment Lyme Disease Syndrome Chronic Pain
Icahn School of Medicine at Mount Sinai
NCT06655844
Effect of Music on Pain and Anxiety in Chronic Pain Patients Undergoing Lumbar Interventional Procedures.
Milton S. Hershey Medical Center
NCT04924244
Optimizing Accelerated TMS for Chronic Pain With Thompson Sampling
University of Minnesota
NCT07103135
Emotional Awareness and Expression Therapy for Chronic Pain and Opioid Use Disorder
University of Michigan
NCT06865560
Physical Activity Pain Resilience
William Black
NCT07049029
External Sensing and Neuromodulation to Assess Diabetic Pain Outcomes (XANADO)
Abbott Medical Devices
NCT05537662
Local Cerebral Oxygenation in Chronic Pain Patients Utilizing Spinal Cord Stimulation
CereVu Medical
NCT06559735
Low-Intensity Focused Ultrasound and the Complex Patient
Virginia Polytechnic Institute and State University
NCT06297200
PAIN: a Project Assessing the Impact of a Novel Cannabinoid Product
Staci Gruber, Ph.D.
NCT03984565
The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature
Faith A. Richardson
NCT05067998
Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans
University of Illinois at Chicago
NCT05094297
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
Indiana University
NCT05603702
Mindfulness-Based Intervention for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease
University of Illinois at Chicago
NCT07402811
Integrated PTSD and Chronic Pain Treatment
Weill Medical College of Cornell University
NCT07225049
The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain
University of Minnesota
NCT05741788
SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease
University of Nebraska
NCT06480786
Improving Spinal Cord Stimulation With ECAPS
University of Minnesota
NCT04938245
Insula Neuromodulation for Chronic Neuropathic Pain
University of Virginia
NCT05404581
Group Medical Visits and Chiropractic Care for Older Adults With Chronic Spine Pain
Brigham and Women's Hospital
NCT06632535
The Role of Brain Dopamine in Chronic Pain
University of Rochester
NCT05285683
VR Mindfulness Training for Veterans With SCI
VA Office of Research and Development
NCT06587607
Mind Body Intervention for Chronic Migraine Headaches
Beth Israel Deaconess Medical Center
NCT06690060
Mindfulness-Based Ecological Momentary Intervention for Opioid Use Disorder and Chronic Pain
Arizona State University
NCT06947122
A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy
University of Chicago
NCT06382272
SMART Stepped Care Management for Low Back Pain in the Military Health System
Brooke Army Medical Center
NCT04172038
A Trial of a Positive Psychology Intervention for Older Adults (RESET)
University of Michigan
NCT05451589
Use of Driving Tests to Evaluate Patient Performance on Oral Opioids
Asokumar Buvanendran
NCT00659035
Adapting and Implementing a Nurse Care Management Model to Care for Rural Patients With Chronic Pain
University of Washington
NCT06407115
STEPS: An Efficacy Trial of a Chronic Pain Self-Management Program for Older Adults
University of Michigan
NCT05278234
PEACE: Comparing Chronic Pain Treatment Options
Memorial Sloan Kettering Cancer Center
NCT02979574
Matching Adults to Treatments for Chronic Pain (MATCH) Study
University of Washington
NCT05699252
HFIT Versus TENS Study for Chronic Low Back and Knee Pain
Hinge Health
NCT05821530
Pharmacogenomics Applied to Chronic Pain Treatment in Primary Care
Medstar Health Research Institute
NCT04685304
Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment
Erin Winstanley
NCT06367387
Non-pharmacological Treatment for Pain After Spine Surgery
Dan Rhon
NCT04770480
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 22 |
| Phase 3 | 7 |
| Phase 4 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on Chronic Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Chronic Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Chronic Pain page
302 registered trials, 139 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 139 Chronic Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Chronic Pain trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Chronic Pain condition card totals 302 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.