Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Optimization of NIBS for Treatment of Addiction
NCT04379115 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to assess the effects of transcranial Direct Current Stimulation (tDCS) applied in conjunction with Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain. The investigators hypothesize that there will be a decrease in drug use and improved psychosocial assessments with active stimulation, when compared to sham stimulation.
Conditions Studied
Interventions
- DEVICE Active Comparator: Active tDCS + Active TUS
- DEVICE Sham Comparator: Sham tDCS + Sham TUS
Study Locations (3)
Illinois
- University of Illinois Health/ University of Illinois at Chicago — Hinsdale
Massachusetts
- Spaulding Rehabilitation Hospital - 5th Floor - Neuromodulation Center — Cambridge
Ohio
- University Hospitals Cleveland Medical Center/ Dahms Clinical Research Unit — Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 126 participants |
| Start Date | 2021-04-04 |
| Est. Completion | 2027-10-31 |
| Phase | NA |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04379115
The ClinicalTrials.gov registry entry for NCT04379115 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 126 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Case Western Reserve University, which has 172 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Chronic Pain appearing as the primary indexed condition, and to 2 interventions — of which Active Comparator: Active tDCS + Active TUS is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04379115 reports 3 study locations spanning 3 distinct geographic areas — top geographies include Illinois, Massachusetts, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04379115 about?
NCT04379115 is a clinical study titled "Optimization of NIBS for Treatment of Addiction". The purpose of this study is to assess the effects of transcranial Direct Current Stimulation (tDCS) applied in conjunction with Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain. The investigators hypothesize that there will be a decrease in drug ...
What is the current status of trial NCT04379115?
This trial is currently recruiting. It is a NA study. The enrollment target is 126 participants. The study started on 2021-04-04. Estimated completion is 2027-10-31.
What conditions does trial NCT04379115 study?
This clinical trial studies the following conditions: Chronic Pain, Opioid-use Disorder. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04379115?
The interventions under investigation include: Active Comparator: Active tDCS + Active TUS (DEVICE), Sham Comparator: Sham tDCS + Sham TUS (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04379115?
This trial is sponsored by Case Western Reserve University, which has 172 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04379115 being conducted?
This trial has 3 study locations across Illinois, Massachusetts, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.