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NCT04379115 · ClinicalTrials.gov registry record · NA
Optimization of NIBS for Treatment of Addiction
A NA study of Chronic Pain and Opioid Use Disorder, sponsored by Case Western Reserve University.
- Recruiting
- Registry status
- NA
- Development phase
- 126
- Enrollment target
- 3
- Study locations
NCT04379115: Recruiting NA study of Chronic Pain and Opioid Use Disorder, sponsored by Case Western Reserve University.
NCT04379115 is a NA study of Chronic Pain and Opioid Use Disorder that is actively recruiting participants, run by Case Western Reserve University. The registered enrollment target is 126 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (84% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04379115, a NA study of Chronic Pain and Opioid Use Disorder, is actively recruiting participants, sponsored by Case Western Reserve University.
- RECRUITING
- Registry status
- NA
- Development phase
- 126 participants
- Enrollment target
- 3
- Study locations
Study Summary
The purpose of this study is to assess the effects of transcranial Direct Current Stimulation (tDCS) applied in conjunction with Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain. The investigators hypothesize that there will be a decrease in drug use and improved psychosocial assessments with active stimulation, when compared to sham stimulation.
Primary Outcome
American Pain Foundation Pain/Medication Diary is used to monitor Drug Use overtime after stimulation for approximately 6 weeks.
Conditions Studied
Interventions
- DEVICE Active Comparator: Active tDCS + Active TUS
- DEVICE Sham Comparator: Sham tDCS + Sham TUS
Study Locations (3)
Illinois
- University of Illinois Health/ University of Illinois at Chicago - Hinsdale
Massachusetts
- Spaulding Rehabilitation Hospital - 5th Floor - Neuromodulation Center - Cambridge
Ohio
- University Hospitals Cleveland Medical Center/ Dahms Clinical Research Unit - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 126 participants |
| Start Date | 2021-04-04 |
| Est. Completion | 2027-10-31 |
| Phase | NA |
What NCT04379115 shows while recruiting
NCT04379115 is an interventional study that assigns participants to a tested intervention. The registered 126 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (84% lower).
The record links to 2 conditions, with Chronic Pain appearing as the primary indexed condition, and to 2 interventions - of which Active Comparator: Active tDCS + Active TUS is the first listed.
NCT04379115 reports a single indexed study location in Illinois, Massachusetts, Ohio.
Frequently Asked Questions
What is clinical trial NCT04379115 about?
NCT04379115 is a clinical study titled "Optimization of NIBS for Treatment of Addiction". The purpose of this study is to assess the effects of transcranial Direct Current Stimulation (tDCS) applied in conjunction with Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain. The investigators hypothesize that there will be a decrease in drug ...
What is the current status of trial NCT04379115?
This trial is currently recruiting. It is a NA study. The enrollment target is 126 participants. The study started on 2021-04-04. Estimated completion is 2027-10-31.
What conditions does trial NCT04379115 study?
This clinical trial studies the following conditions: Chronic Pain, Opioid Use Disorder.
What interventions are being tested in trial NCT04379115?
The interventions under investigation include: Active Comparator: Active tDCS + Active TUS (DEVICE), Sham Comparator: Sham tDCS + Sham TUS (DEVICE).
Who is sponsoring clinical trial NCT04379115?
This trial is sponsored by Case Western Reserve University, which has 141 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04379115 being conducted?
This trial has 3 study locations across Illinois, Massachusetts, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04379115's enrollment target sits among peer trials
126 114th of 301 higher than 187 of 301 other Chronic Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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