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NCT05068908 · ClinicalTrials.gov registry record
Brain Connectivity Patterns in Chronic Temporomandibular Joint Disorders
A clinical trial of Chronic Pain and Temporomandibular Joint Disorders, sponsored by University of Minnesota.
- Recruiting
- Registry status
- 95
- Enrollment target
- 1
- Study location
NCT05068908: Recruiting study of Chronic Pain and Temporomandibular Joint Disorders, sponsored by University of Minnesota.
NCT05068908 is a study of Chronic Pain and Temporomandibular Joint Disorders that is actively recruiting participants, run by University of Minnesota. The registered enrollment target is 95 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05068908, a study of Chronic Pain and Temporomandibular Joint Disorders, is actively recruiting participants, sponsored by University of Minnesota.
- RECRUITING
- Registry status
- 95 participants
- Enrollment target
- 1
- Study location
Study Summary
This study addresses the timely problem of painful temporomandibular disorders (TMD), the most common cause of orofacial pain second only to tooth pain. Findings from previous studies suggest that dysregulation of connectivity within specific brain circuits is part of chronic pain pathophysiology. This study will identify connectivity patterns within those brain circuits as potential signatures for pain- related disability in chronic TMD pain participants. New knowledge regarding these brain connectivity patterns is expected to be significant because it will support improved phenotyping of this heterogeneous participant population. It is also expected that this finding can potentially be extrapolated to other chronic pain conditions, such as back pain, migraine headache, and fibromyalgia that are frequently comorbid conditions in chronic TMD participants.
Primary Outcome
Multi-modal MRI data will be used to assess functional connectivity patterns within the thalamocortical brain circuit in chronic TMD pain participants and pain free controls. Functional connectivity will be reported as a unitless value. Neuroimaging will be conducted during Visit 3.
Conditions Studied
Study Locations (1)
Minnesota
- University of Minnesota - Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 95 participants |
| Start Date | 2022-03-02 |
| Est. Completion | 2026-08-31 |
What NCT05068908 shows while recruiting
NCT05068908 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 95 participants, a relatively small participant target, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (88% lower).
The record links to 3 conditions, with Chronic Pain appearing as the primary indexed condition, and to 0 interventions.
NCT05068908 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT05068908 about?
NCT05068908 is a clinical study titled "Brain Connectivity Patterns in Chronic Temporomandibular Joint Disorders". This study addresses the timely problem of painful temporomandibular disorders (TMD), the most common cause of orofacial pain second only to tooth pain. Findings from previous studies suggest that dysregulation of connectivity within specific brain circuits is part of chronic pain pathophysiology. T...
What is the current status of trial NCT05068908?
This trial is currently recruiting. The enrollment target is 95 participants. The study started on 2022-03-02. Estimated completion is 2026-08-31.
What conditions does trial NCT05068908 study?
This clinical trial studies the following conditions: Chronic Pain, Temporomandibular Joint Disorders, Temporomandibular Joint Pain.
Who is sponsoring clinical trial NCT05068908?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05068908 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05068908's enrollment target sits among peer trials
95 142nd of 301 higher than 159 of 301 other Chronic Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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