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NCT05661903 · ClinicalTrials.gov registry record · Phase 2
From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects
A Phase 2 study of Chronic Pain, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 180
- Enrollment target
- 3
- Study locations
NCT05661903 is a Phase 2 study of Chronic Pain that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 180 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (77% lower). The trial reports 3 study locations across 1 state.
The verdict
NCT05661903, a Phase 2 study of Chronic Pain, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 180 participants
- Enrollment target
- 3
- Study locations
Study Summary
This is a multicenter prospective study of patients who currently have stably implanted spinal cord simulators. Patients will be randomly assigned to turn on or off their spinal cord stimulators for two week intervals up to six weeks after enrollment, and on the final day of study participation, for one hour intervals, in a multi-crossover design. In a subset of patients we will also perform combined positron emission tomography/magnetic resonance imaging at baseline, week 2 and week 4.
Conditions Studied
Interventions
- OTHER Usual Care
- OTHER Spinal Cord Stimulator Set to Minimal/No Stimulation Setting
- DRUG Positron Emission Tomography / Magnetic Resonance Imaging
Study Locations (3)
Massachusetts
- Massachusetts General Hospital - Boston
- Beth Israel Deaconess Medical Center - Boston
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2023-06-08 |
| Est. Completion | 2027-08-31 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05661903
The ClinicalTrials.gov registry entry for NCT05661903 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (77% lower). The listed sponsor is Massachusetts General Hospital, which has 2,032 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Chronic Pain appearing as the primary indexed condition, and to 3 interventions - of which Usual Care is the first listed.
NCT05661903 reports 3 study locations spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05661903 about?
NCT05661903 is a clinical study titled "From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects". This is a multicenter prospective study of patients who currently have stably implanted spinal cord simulators. Patients will be randomly assigned to turn on or off their spinal cord stimulators for two week intervals up to six weeks after enrollment, and on the final day of study participation, for...
What is the current status of trial NCT05661903?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 180 participants. The study started on 2023-06-08. Estimated completion is 2027-08-31.
What conditions does trial NCT05661903 study?
This clinical trial studies the following conditions: Chronic Pain.
What interventions are being tested in trial NCT05661903?
The interventions under investigation include: Usual Care (OTHER), Spinal Cord Stimulator Set to Minimal/No Stimulation Setting (OTHER), Positron Emission Tomography / Magnetic Resonance Imaging (DRUG).
Who is sponsoring clinical trial NCT05661903?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05661903 being conducted?
This trial has 3 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.