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RECRUITING Phase 2

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

NCT05959434 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this clinical trial is to test the efficacy of a novel integrative cognitive-behavioral intervention in patients with posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Specific Aim 1: Examine the efficacy of CPT-RP, as compared to RP alone, in reducing alcohol frequency (percent days drinking) and quantity (drinks per drinking day) as measured by the Timeline Follow-Back (TLFB). Specific Aim 2: Examine the efficacy of CPT-RP, as compared to RP alone, in reducing PTSD symptoms as measured by the Clinician Administered PTSD Scale (CAPS-5). Specific Aim 3: Use ecological momentary assessment (EMA) to evaluate intervention effects on daily alcohol-related cognitions and behaviors through real-time associations with PTSD symptomatology and distress tolerance. Researchers will compare integrative CPT+RP with RP-alone to see if CPT+RP is more efficacious in reducing alcohol use and PTSD symptom severity.

Interventions

  • BEHAVIORAL Cognitive Processing Therapy + Relapse Prevention
  • BEHAVIORAL Relapse Prevention

Study Locations (2)

South Carolina

  • Medical University of South Carolina — Charleston

Texas

  • Texas A&M University — College Station

Trial Details

FieldValue
Enrollment Target 200 participants
Start Date 2024-04-01
Est. Completion 2028-07-31
Phase Phase 2

Sponsor

Texas A&M University

66 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05959434

The ClinicalTrials.gov registry entry for NCT05959434 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Texas A&M University, which has 66 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Alcohol Use Disorder appearing as the primary indexed condition, and to 2 interventions — of which Cognitive Processing Therapy + Relapse Prevention is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05959434 reports 2 study locations spanning 2 distinct geographic areas — top geographies include South Carolina, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05959434 about?

NCT05959434 is a clinical study titled "Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD". The goal of this clinical trial is to test the efficacy of a novel integrative cognitive-behavioral intervention in patients with posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Specific Aim 1: Examine the efficacy of CPT-RP, as compared to RP alone, in reducing alcohol frequen...

What is the current status of trial NCT05959434?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 200 participants. The study started on 2024-04-01. Estimated completion is 2028-07-31.

What conditions does trial NCT05959434 study?

This clinical trial studies the following conditions: Alcohol Use Disorder, Posttraumatic Stress Disorder. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05959434?

The interventions under investigation include: Cognitive Processing Therapy + Relapse Prevention (BEHAVIORAL), Relapse Prevention (BEHAVIORAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05959434?

This trial is sponsored by Texas A&M University, which has 66 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05959434 being conducted?

This trial has 2 study locations across South Carolina, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial