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NCT04523922 · ClinicalTrials.gov registry record · Phase 2

Oxytocin to Enhance Integrated Treatment for AUD and PTSD

A Phase 2 study of Alcohol Use Disorder and PTSD, sponsored by Medical University of South Carolina.

Recruiting
Registry status
Phase 2
Development phase
180
Enrollment target
1
Study location

NCT04523922 is a Phase 2 study of Alcohol Use Disorder and PTSD that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 180 participants, below the 327-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (45% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT04523922, a Phase 2 study of Alcohol Use Disorder and PTSD, is actively recruiting participants, sponsored by Medical University of South Carolina.

RECRUITING
Registry status
Phase 2
Development phase
180 participants
Enrollment target
1
Study location

Study Summary

The primary objective of the proposed Stage II study is to examine the efficacy of oxytocin (OT) as compared to placebo in reducing (1) alcohol use disorder (AUD) symptoms, and (2) post-traumatic stress disorder (PTSD) symptoms among Veterans receiving COPE therapy (Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure). To evaluate purported neurobiological mechanisms of change, we will employ functional magnetic resonance imaging (fMRI) at pre- and post-treatment.

Conditions Studied

Alcohol Use Disorder PTSD

Interventions

  • DRUG Placebo
  • DRUG 40 IU Intranasal Oxytocin
  • BEHAVIORAL Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure

Study Locations (1)

South Carolina

  • Medical University of South Carolina - Charleston

Trial Details

FieldValue
Enrollment Target 180 participants
Start Date 2021-03-29
Est. Completion 2026-12-01
Phase Phase 2

Sponsor

Medical University of South Carolina

755 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04523922

The ClinicalTrials.gov registry entry for NCT04523922 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 327-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (45% lower). The listed sponsor is Medical University of South Carolina, which has 755 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Alcohol Use Disorder appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.

NCT04523922 reports 1 study location spanning 1 distinct geographic area - top geographies include South Carolina.

Frequently Asked Questions

What is clinical trial NCT04523922 about?

NCT04523922 is a clinical study titled "Oxytocin to Enhance Integrated Treatment for AUD and PTSD". The primary objective of the proposed Stage II study is to examine the efficacy of oxytocin (OT) as compared to placebo in reducing (1) alcohol use disorder (AUD) symptoms, and (2) post-traumatic stress disorder (PTSD) symptoms among Veterans receiving COPE therapy (Concurrent Treatment of PTSD and ...

What is the current status of trial NCT04523922?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 180 participants. The study started on 2021-03-29. Estimated completion is 2026-12-01.

What conditions does trial NCT04523922 study?

This clinical trial studies the following conditions: Alcohol Use Disorder, PTSD.

What interventions are being tested in trial NCT04523922?

The interventions under investigation include: Placebo (DRUG), 40 IU Intranasal Oxytocin (DRUG), Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure (BEHAVIORAL).

Who is sponsoring clinical trial NCT04523922?

This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04523922 being conducted?

This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.