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NCT05677321 · ClinicalTrials.gov registry record
Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)
A clinical trial of Alcohol Use Disorder, sponsored by National Institute on Alcohol Abuse and Alcoholism (NIAAA).
- Recruiting
- Registry status
- 475
- Enrollment target
- 1
- Study location
NCT05677321: Recruiting study of Alcohol Use Disorder, sponsored by National Institute on Alcohol Abuse and Alcoholism (NIAAA).
NCT05677321 is a study of Alcohol Use Disorder that is actively recruiting participants, run by National Institute on Alcohol Abuse and Alcoholism (NIAAA). The registered enrollment target is 475 participants, above the 326-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (46% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05677321, a study of Alcohol Use Disorder, is actively recruiting participants, sponsored by National Institute on Alcohol Abuse and Alcoholism (NIAAA).
- RECRUITING
- Registry status
- 475 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: Alcohol use disorder (AUD) is the most common substance use disorder in the world. Long-term AUD can affect a person s sense of taste and smell. This natural history study will compare alcohol drinking behaviors and measures of taste and smell in people with and without AUD. Objective: To understand how alcohol use changes the senses of taste and smell. Eligibility: People aged 18 to 65 years with or without AUD. Design: Participants will be screened. They will have several tests to assess their smell and taste functions. They will answer questions about their eating, alcohol use, and smoking or vaping habits. Participants will have 2 study visits. They will give samples of blood, nasal mucous, saliva, stool, and urine. Their bodies will be measured. They will undergo a type of scan that uses X-rays to measure their body composition. They will complete taste measurements. They will taste liquids by swishing them in their mouth, without swallowing. Then, they will be asked what they can detect and which flavors they preferred. They will also complete smell measurements. They will be asked if they can identify strong odors on a metal wand. They will be asked to rate the intensity and pleasantness of odors. Their brain activity in the frontal regions will be measured while they smell various odors. For this, we will use a brain imaging tool called functional near infrared spectroscopy. They will have sensory testing. Sensations such as pressure, pinpricks, heat, or vibrations will be applied to their skin. Then, they will be asked what they felt. They will keep diaries. They will write down what they eat (for 3 days), the alcohol they drink (3 days), and how much they sleep (14 days). They will wear a wristwatch-like device that records their activity for 14 days.
Primary Outcome
Compare individuals with AUD to those without AUD in measures of taste and smell and alcohol drinking behaviors.
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 475 participants |
| Start Date | 2024-01-09 |
| Est. Completion | 2027-12-31 |
What NCT05677321 shows while recruiting
NCT05677321 is an observational study that tracks outcomes without assigning an intervention. The registered 475 participants enrollment target is mid-sized for trials with a published cap, above the 326-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (46% higher).
The record links to 1 condition, with Alcohol Use Disorder appearing as the primary indexed condition, and to 0 interventions.
NCT05677321 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT05677321 about?
NCT05677321 is a clinical study titled "Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)". Background: Alcohol use disorder (AUD) is the most common substance use disorder in the world. Long-term AUD can affect a person s sense of taste and smell. This natural history study will compare alcohol drinking behaviors and measures of taste and smell in people with and without AUD. Objective:...
What is the current status of trial NCT05677321?
This trial is currently recruiting. The enrollment target is 475 participants. The study started on 2024-01-09. Estimated completion is 2027-12-31.
What conditions does trial NCT05677321 study?
This clinical trial studies the following conditions: Alcohol Use Disorder.
Who is sponsoring clinical trial NCT05677321?
This trial is sponsored by National Institute on Alcohol Abuse and Alcoholism (NIAAA), which has 93 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05677321 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05677321's enrollment target sits among peer trials
475 15th of 184 higher than 170 of 184 other Alcohol Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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