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RECRUITING Phase 2

Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)

NCT05042102 · View on ClinicalTrials.gov ↗

Study Summary

The goal of the project is to evaluate whether donepezil + cognitive remediation therapy is superior to placebo in reducing heavy drinking in patients with alcohol use disorder in a double-blind, placebo-controlled trial.

Conditions Studied

Interventions

  • COMBINATION_PRODUCT Donepezil + Cognitive remediation therapy (CRT)
  • COMBINATION_PRODUCT Donepezil + Placebo CRT
  • COMBINATION_PRODUCT Placebo medication + Cognitive remediation therapy (CRT)
  • COMBINATION_PRODUCT Placebo medication + Placebo CRT

Study Locations (1)

Connecticut

  • VA Connecticut Healthcare System — West Haven

Trial Details

FieldValue
Enrollment Target 160 participants
Start Date 2022-08-08
Est. Completion 2027-05-31
Phase Phase 2

Sponsor

VA Connecticut Healthcare System

7 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05042102

The ClinicalTrials.gov registry entry for NCT05042102 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 160 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is VA Connecticut Healthcare System, which has 7 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Alcohol Use Disorder appearing as the primary indexed condition, and to 4 interventions — of which Donepezil + Cognitive remediation therapy (CRT) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05042102 reports 1 study location spanning 1 distinct geographic area — top geographies include Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05042102 about?

NCT05042102 is a clinical study titled "Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)". The goal of the project is to evaluate whether donepezil + cognitive remediation therapy is superior to placebo in reducing heavy drinking in patients with alcohol use disorder in a double-blind, placebo-controlled trial.

What is the current status of trial NCT05042102?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 160 participants. The study started on 2022-08-08. Estimated completion is 2027-05-31.

What conditions does trial NCT05042102 study?

This clinical trial studies the following conditions: Alcohol Use Disorder. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05042102?

The interventions under investigation include: Donepezil + Cognitive remediation therapy (CRT) (COMBINATION_PRODUCT), Donepezil + Placebo CRT (COMBINATION_PRODUCT), Placebo medication + Cognitive remediation therapy (CRT) (COMBINATION_PRODUCT), Placebo medication + Placebo CRT (COMBINATION_PRODUCT). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05042102?

This trial is sponsored by VA Connecticut Healthcare System, which has 7 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05042102 being conducted?

This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial