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Alcohol Use Disorder clinical trials
109 of 185 indexed Alcohol Use Disorder trials are currently recruiting.
185 US clinical trials · 109 currently recruiting
Alcohol Use Disorder is the subject of 185 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 75 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 13 of these trials.
The research picture
Alcohol Use Disorder has 185 registered US clinical trials, 109 of them open to new participants right now, about 59% of the total.
- 109
- recruiting participants now
- 59%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Yale University
Active & Recent Trials
185 total, page 1 of 4
Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP
National Institute on Drug Abuse (NIDA)
NCT06552741
NIAAA Natural History Protocol
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT02231840
Systematic Implementation of Patient-centered Care for Alcohol Use Trial: Beyond Referral to Treatment
Kaiser Permanente
NCT06318026
A Study of Brenipatide in Participants With Alcohol Use Disorder
Eli Lilly and Company
NCT07219953
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
Eli Lilly and Company
NCT07219966
Removing Barriers: Community Partnering for Innovative Solutions to the Opioid Crisis
University of Michigan
NCT05665179
A Peer Recovery Coaching Intervention for Hospitalized Alcohol Use Disorder Patients
Clemson University
NCT06479681
A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners
Stanford University
NCT05619185
Trial of a Culturally Informed Brief Intervention to Reduce Alcohol Related Health Disparities and Treatment Inequities Among Latinxs
University of Texas, El Paso
NCT05800899
Enhancing Prospective Thinking in Early Recovery (HOME)
Indiana University
NCT06302413
Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT05677321
Promoting Alcohol Treatment Engagement Post-hospitalization
Yale University
NCT05338151
TRAC-ER Intervention to Reduce Risky Alcohol Use and HIV Risk
University of Kentucky
NCT05576350
Leveraging Virtual Care Strategies to Improve Access and Treatment for Individuals With Alcohol Use Disorders
University of Michigan
NCT05594238
Brief Family Involved Treatment Telehealth
Medical University of South Carolina
NCT05674409
Emergency Medicine Peer Outreach Worker Engagement for Recovery
University of California, Los Angeles
NCT06320015
Behavioral and Functional Task Development, Implementation, and Testing
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT02108054
Cannabis' Impact on Alcohol Consumption
Brown University
NCT05389930
Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
Evon Medics
NCT06434818
Testing a PTSD m-Health Intervention to Improve Alcohol Treatment Outcomes
Michigan State University
NCT05564663
A Study to Evaluate Mazdutide Compared With Placebo in Participants With Alcohol Use Disorder
Eli Lilly and Company
NCT06817356
Implementation of Mobile-based Programs for Alcohol Cessation in Treatment of Alcohol-associated Liver Disease
University of Wisconsin, Madison
NCT06305624
Integrated Treatment for Enhancing Growth in Recovery During Adolescence
Massachusetts General Hospital
NCT06395467
Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity
University of Minnesota
NCT05117255
Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related Drinking
Ohio State University
NCT07214207
Impulsivity Domains and Subjective Response
Jessica Weafer
NCT05929677
Brexpiprazole in Alcohol Use Disorder
University of Colorado, Denver
NCT04066192
Emergency Department-Initiated Medications for Alcohol Use Disorder
Yale University
NCT05827159
Alcohol and the Social Brain: an Alcohol-Administration Hyperscanning Study
University of Illinois at Urbana-Champaign
NCT06687525
Testing a Lifestyle Physical Activity Intervention for Women With Depression in Alcohol Treatment
Butler Hospital
NCT04667520
Motivation for IV Alcohol Self-Administration in Humans
University of California, Los Angeles
NCT06494891
Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for SAH
Johns Hopkins University
NCT03845205
Guanfacine for Alcohol Use Disorder (AUD)
Indiana University
NCT06629259
Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUD
NYU Langone Health
NCT06349083
Virtual Incentive Treatment for Alcohol
Washington State University
NCT06265506
Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD
Texas A&M University
NCT05959434
Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment of Alcohol Use Disorder (AUD)
Brainsway
NCT07216872
Oxytocin to Enhance Integrated Treatment for AUD and PTSD
Medical University of South Carolina
NCT04523922
Alcohol Use Disorder and Cannabidiol
University of Colorado, Denver
NCT05613608
AAT for Alcohol Use Disorder in Veterans
VA Office of Research and Development
NCT05372029
Role of Phosphatidylethanol in Predicting Perioperative Outcomes of Admitted Patients at UHCMC
University Hospitals Cleveland Medical Center
NCT06864819
A Female-Specific CBT Group for Veteran Women With Alcohol Use Disorder in VA Primary Care Settings
University of Massachusetts, Worcester
NCT06118346
Electronic Harm Reduction Treatment for Alcohol
University of Washington
NCT06702007
Sex Differences in the Response to Abstinence From Alcohol.
Indiana University
NCT03827460
Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)
VA Connecticut Healthcare System
NCT05042102
Image-guided, Robot Navigated Transcranial Magnetic Stimulation (IR-TMS) for Alcohol Use Disorder (AUD)
The University of Texas Health Science Center at San Antonio
NCT06648642
Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD
NYU Langone Health
NCT03667846
Alcohol Research in HIV: Relapse Prevention
Johns Hopkins University
NCT05163301
Pregnenolone for the Treatment of Alcohol Use Disorder
Yale University
NCT05781009
Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat
Yale University
NCT06371404
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 26 |
| Phase 2 | 49 |
| Phase 3 | 5 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Alcohol Use Disorder Trial Landscape
185 indexed Alcohol Use Disorder studies · 109 recruiting (59%).
Phase mix: 8 late (III/IV) vs 75 early (I/II).
Top sponsor: Yale University (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Alcohol Use Disorder?
PlainTrial tracks 185 US clinical trials for Alcohol Use Disorder, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Alcohol Use Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.