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A Study of DB-1310 in Advanced/Metastatic Solid Tumors
NCT05785741 · View on ClinicalTrials.gov ↗
Study Summary
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1310 in subjects with advanced solid tumors.
Conditions Studied
Interventions
- DRUG Trastuzumab
- DRUG Osimertinib
- DRUG DB-1310
Study Locations (20)
Florida
- D&H Cancer Research Center LLC — Margate
- Sarah Cannon Research Institute at Florida Cancer Specialists — Orlando
- BRCR global — Plantation
- Florida Cancer Specialists — Sarasota
- BRCR Medical Center Inc. — Tamarac
California
- University of California, Davis Comprehensive Cancer Center — Sacramento
- UCLA Hematology/Oncology - Santa Monica — Santa Monica
Jiangsu
- Jiangsu Province hospital — Nanjing
- Affiliated Hospital of Jiangnan University — Wuxi
Georgia
- Research Site 111 — Atlanta
Massachusetts
- Dana-Farber Cancer Institute — Boston
Michigan
- Henry Ford Health System — Detroit
Ohio
- Carl & Edyth Lindner Center for Research & Education at The Christ Hospital and The Christ Hospital Cancer Center — Cincinnati
Tennessee
- Tennessee Oncology, PLLC — Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,000 participants |
| Start Date | 2023-04-10 |
| Est. Completion | 2026-08-31 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05785741
The ClinicalTrials.gov registry entry for NCT05785741 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is DualityBio, which has 40 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Advanced Solid Tumor appearing as the primary indexed condition, and to 3 interventions — of which Trastuzumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05785741 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Florida, California, Jiangsu. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05785741 about?
NCT05785741 is a clinical study titled "A Study of DB-1310 in Advanced/Metastatic Solid Tumors". This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1310 in subjects with advanced solid tumors.
What is the current status of trial NCT05785741?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 1,000 participants. The study started on 2023-04-10. Estimated completion is 2026-08-31.
What conditions does trial NCT05785741 study?
This clinical trial studies the following conditions: Advanced Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05785741?
The interventions under investigation include: Trastuzumab (DRUG), Osimertinib (DRUG), DB-1310 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05785741?
This trial is sponsored by DualityBio, which has 40 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05785741 being conducted?
This trial has 20 study locations across California, Florida, Georgia, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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